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A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS\; MIM 209920). Zusätzlich bieten wir Ihnen RFX5 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal RFX5 Primary Antibody für GS, WB - ABIN106544
Xu, Sengupta, Seto, Smith: Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression. in The Journal of biological chemistry 2006
Human Polyclonal RFX5 Primary Antibody für IHC (p), IP - ABIN151448
Ulbricht, Alzrigat, Horch, Reuter, von Mikecz, Steimle, Schmitt, Krämer, Stamminger, Hemmerich: PML promotes MHC class II gene expression by stabilizing the class II transactivator. in The Journal of cell biology 2012
Human Polyclonal RFX5 Primary Antibody für ELISA, WB - ABIN4350280
Kong, Fang, Li, Fang, Xu: HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. in Journal of molecular and cellular cardiology 2009
RFX5 acts as a direct positive transcriptional regulator of TPP1 (zeige TPP1 Antikörper) in hepatocellular carcinoma.
Data show arginine methyltransferase PRMT6 (zeige PRMT6 Antikörper) methylates the AT-hook motif of regulatory factor RFX5 and downregulates HLA-DQ expression.
these data have identified as novel pathway whereby SIRT1 (zeige SIRT1 Antikörper) maintains COL1A2 (zeige COL1A2 Antikörper) synthesis in SMCs by modulating RFX5 activity.
RFXAP (zeige RFXAP Antikörper)(C) consists of two alpha-helices that form a V-shaped structure that packs within the RFX5(N)(2) staple.
interaction at COL1A2 (zeige COL1A2 Antikörper) start site and transcription repression
The mutation for the fifth Bbare lymphocyte syndrome complementation group was found in RFX5 and was mapped to one of the arginines in a DNA-binding surface of this protein. Its wild-type counterpart restored function.
RFX5 binds to the collagen transcription start site and represses collagen gene expression
The identification of nuclear import and export sites on RFX molecules provides potential targets to modulate MHC class II expression.
results demonstrate that RFX1 (zeige RFX1 Antikörper) and RFX5 differentially interact with class I HDACs underlying the different pathways when repressing collagen synthesis
PPARgamma (zeige PPARG Antikörper) is within the RFX5.CIITA (zeige CIITA Antikörper) complex as judged by co-immunoprecipitation and DNA affinity precipitation studies
TSA (zeige PRDX2 Antikörper) treatment enhances the association of CIITA (zeige CIITA Antikörper) with the transcription factor RFX5, which ameliorates the down-regulation of CIITA (zeige CIITA Antikörper) recruitment to target promoters by HDAC2 (zeige HDAC2 Antikörper).
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS\; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
DNA-binding protein RFX5
, regulatory factor X 5
, DNA-binding protein Rfx5
, regulatory factor X, 5
, regulator factor X 5