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RFX1 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. Zusätzlich bieten wir Ihnen Regulatory Factor X, 1 (Influences HLA Class II Expression) Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal RFX1 Primary Antibody für IP, WB - ABIN4350267
Su, Tseng, Hsu, Tai, Huang, Ko, Lin, Liu, Chen, Shiau: RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. in Oncotarget 2014
Human Polyclonal RFX1 Primary Antibody für ICC, IF - ABIN4350269
Zhu, Li, Yang, Tian, Wang, Yuan, Dong, He, Wang, Li: Dynamics of the Transcriptome during Human Spermatogenesis: Predicting the Potential Key Genes Regulating Male Gametes Generation. in Scientific reports 2016
Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR (zeige MLXIP Antikörper)-124 regulation; identified the binding site through which RFX1 directly regulates ApoE (zeige APOE Antikörper), may explain the missing link between decreased miRNA-124 and ineffective Abeta (zeige APP Antikörper) uptaking during aging.
induction of ciliogenesis increases the expression of RFX and dyslexia candidate genes
Data show that transcription factor regulatory factor X 1 (RFX1) protein expression can be tightly regulated by polyubiquitination-mediated proteosomal degradation via STIP1 homology and U-box containing protein 1 (STUB1 (zeige STUB1 Antikörper)).
Data indicate that regulatory factor X transcription factor RFX-1 regulates SC-2001-mediated SHP-1 Phosphatase transcription in hepatocellular carcinoma cells.
regulatory factor 1 directly regulates CD44 (zeige CD44 Antikörper) expression in glioblastoma
Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs (zeige TWIST1 Antikörper).
RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK (zeige EPHB2 Antikörper) signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription.
NLRC5 (zeige NLRC5 Antikörper)-mediated histocompatibiility class I gene induction requires the W/S and X1, X2 cis (zeige CISH Antikörper)-regulatory elements.
in serum- or IGF-1-stimulated breast cancer MCF-7 cells, JNK induces SHP1 expression through the binding of AP-4 and RFX-1 transcription factors to the epithelial tissue-specific SHP1 promoter.
RFX1 recruits SUV39H1 (zeige SUV39H1 Antikörper) to the promoter regions of the CD11a (zeige ITGAL Antikörper) and CD70 (zeige CD70 Antikörper) genes in CD4 (zeige CD4 Antikörper)(+) T cells, thereby regulating local H3K9 tri (zeige VANGL2 Antikörper)-methylation levels.
This study suggests that ciliogenic Rfx transcription factors regulate Msi1 (zeige MSI1 Antikörper) expression in neural stem/progenitor cells.
RFX1 may have negative effect on cell proliferation of Sertoli cells via modulating Spata4 (zeige SPATA4 Antikörper) expression levels by binding the conserved 14-bp cis (zeige CISH Antikörper)-elements of Spata4 (zeige SPATA4 Antikörper) promoter.
Rfx1 could be an indicator of progression from Barrett's esophagus to adenocarcinoma.
These results suggest a significant expression of RFX1 proteins in the mammalian brain.
RFX1 may negatively regulate the self-renewal of GBM-SCs (zeige TWIST1 Antikörper) through modulating FGF-1B and FGF1 (zeige FGF1 Antikörper) expression levels by binding the 18-bp cis (zeige CISH Antikörper)-elements of the F1B promoter.
RFX1 may play roles in haploid cells during mouse spermatogenesis
RFX1 mediates the immediate early (zeige JUN Antikörper) response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells.
RFX1 regulates expression of genes that are essential for early embryonic development/survival and that RFX1 function can not be compensated by other RFX1 family members.
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.
MHC class II regulatory factor RFX
, MHC class II regulatory factor RFX1
, enhancer factor C
, regulatory factor X 1
, trans-acting regulatory factor 1
, transcription factor RFX1
, vregulatory factor X, 1 (influences HLA class II expression)
, regulatory factor X1