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In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. Zusätzlich bieten wir Ihnen RTEL1 Antikörper (35) und und viele weitere Produktgruppen zu diesem Protein an.
The RTEL1 homolog in Arabidopsis thaliana plays multiple roles in preserving genome stability.
SNPs in the RTEL1 are associated with COPD (zeige ARCN1 ELISA Kits) in a Chinese Han population. It is possible that these variants are COPD (zeige ARCN1 ELISA Kits) risk factors.
This meta-analysis demonstrates that the RTEL1 rs2297440 polymorphism plays a moderate, but significant role in the risk of glioma.
Genetic risk variants in the RTEL1 gene is associated with somatic biomarkers in glioma.
Deletion in the RTEL1 gene is associated with metastatic glioblastoma.
Heterozygous RTEL1 mutations are responsible for familial pulmonary fibrosis (FPF (zeige TNFRSF1A ELISA Kits)) and, thereby, extend the clinical spectrum of RTEL1 deficiency. Thus, RTEL1 enlarges the number of telomere-associated genes implicated in FPF (zeige TNFRSF1A ELISA Kits).
results suggest a significant association between the RETL1, TREH, and PHLDB1 genes and GBM development in the Han Chinese population
A homozygous mutation of RTEL1 in a child presenting with an apparently isolated natural killer cell deficiency.
RTEL1 single nucleotide polymorphisms are associated with decreased susceptibility to pediatric brain astrocytoma.
Association between the RTEL1 rs6010620 polymorphism and glioma risk was significant. [Meta-Analysis]
PARN (zeige PARN ELISA Kits) and RTEL1 mutation carriers had shortened leukocyte telomere lengths.
RTEL1 plays a critical role in both telomere and genome-wide replication, which is crucial for genetic stability and tumor avoidance.
Upregulated RTEL1 is tumorigenic and is able to initiate the formation of hepatocellular carcinoma in mice.
RTEL1 performs two distinct functions at telomeres: it disassembles T loops and also counteracts telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
Cloned a bovine regulator of telomere length elongation helicase (zeige DNA2 ELISA Kits) (RTEL) homolog and characterized its gene structure, expression distribution, splice variants and profile of DNA methylation (zeige HELLS ELISA Kits) around two putative transcription start sites.
In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability and telomere length. This gene is the human ortholog of the mouse Rtel gene, so its protein product may play similar roles in humans. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), generates a non-coding transcript. Multiple transcript variants encoding different isoforms have been described for this gene.
regulator of telomere elongation helicase 1
, helicase-like protein NHL
, regulator of telomere length
, DEAH helicase
, regulator of telomere length helicase 1