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RHOT2 encodes a member of the Rho family of GTPases. Zusätzlich bieten wir Ihnen Ras Homolog Gene Family, Member T2 Antikörper (38) und viele weitere Produktgruppen zu diesem Protein an.
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Miro and Cenp-F (zeige CENPF Proteine) promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.
The Miro2-mediated mitochondrial transport in neurons and recently highlighted involvement of Miro2 proteins in mitochondrial turnover, emerging as a key process affected in neurodegeneration.
Study shows that both PINK1 (zeige PINK1 Proteine) and Parkin (zeige PARK2 Proteine) halt mitochondrial movement; PINK1 (zeige PINK1 Proteine) phosphorylates Miro (1 (zeige RHOT1 Proteine) and 2) and thereby initiates the rapid degradation of Miro through a Parkin (zeige PARK2 Proteine)- and proteasome-dependent pathway.
Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106 (zeige TRAK1 Proteine), suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules.
Miro proteins serve as a [Ca(2 (zeige CA2 Proteine)+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.
Using mouse knockout strategies, we demonstrate that Miro1 (zeige RHOT1 Proteine), as opposed to Miro2, is the primary regulator of mitochondrial transport in both axons and dendrites. Miro1 (zeige RHOT1 Proteine) deletion leads to depletion of mitochondria from distal dendrites but not axons, accompanied by a marked reduction in dendritic complexity. Disrupting postnatal mitochondrial distribution in vivo by deleting Miro1 (zeige RHOT1 Proteine) in mature neurons causes a progressive loss
Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.
molecular cloning and characterization of a novel mouse cDNA encoding a putative atypical GTPase (zeige RACGAP1 Proteine) protein, Arht2
This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics.
ras homolog gene family, member T2
, mitochondrial Rho GTPase 2-like
, mitochondrial Rho (MIRO) GTPase 2
, mitochondrial Rho GTPase 2
, miro protein
, mitochondrial Rho 2
, ras homolog gene family member T2
, rho GTPase