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RHOQ encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Zusätzlich bieten wir Ihnen RHOQ Antikörper (36) und RHOQ Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Exocytosis of Rab11 (zeige RAB11A ELISA Kits)- and L1-positive vesicles may play a central role in TC10-mediated neurite outgrowth
Novel tumor-associated increase of RNA editing in ras homologue family member Q (RHOQ) transcripts, is reported.
The enhancement of Cb-induced gephyrin (zeige GPHN ELISA Kits) clustering by GTP (zeige AK3 ELISA Kits)-TC10 does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors
The exocyst complex is required for targeting of Glut4 (zeige SLC2A4 ELISA Kits) to the plasma membrane by insulin (zeige INS ELISA Kits)
Overexpression of the Rho family member TC10alpha, disrupts adipocyte cortical actin structure and inhibits insulin (zeige INS ELISA Kits)-stimulated GLUT4 (zeige SLC2A4 ELISA Kits) translocation
The GTP (zeige AK3 ELISA Kits)-bound form of TC10 directs the trafficking of CFTR (zeige CFTR ELISA Kits) from the juxtanuclear region to the secretory pathway toward the plasma membrane
The crystal structure of TC10 proved that the basic region of WASp (zeige WASL ELISA Kits) and two unique glutamates in Cdc42 (zeige CDC42 ELISA Kits) generate favorable electrostatic steering forces that control the accelerated WASp (zeige WASL ELISA Kits)-Cdc42 (zeige CDC42 ELISA Kits) association reaction.
We propose that an EGF (zeige EGF ELISA Kits)-stimulated GAP accelerates GTP (zeige AK3 ELISA Kits) hydrolysis of TC10, thereby promoting vesicle fusion.
These findings reveal a novel signaling pathway in human skeletal muscle that involves obscurin (zeige OBSCN ELISA Kits) and the Rho GTPase (zeige RACGAP1 ELISA Kits) TC10 and implicate this pathway in new sarcomere formation.
this study defines TC10 as an immunomodulatory molecule playing a role in physiological B cell responses
activation of TC10 and remodeling of cortical actin, which could occur through the TC10 signaling, are required for osmotic shock-mediated Glut 4 (zeige SLC2A4 ELISA Kits) translocation and glucose u
structural determinants necessary for TC10 trafficking, localization, and function in adipocytes
PKCzeta (zeige PRKCZ ELISA Kits)/lambda can serve as a convergent downstream target for both the PI 3 (zeige PI3 ELISA Kits)-kinase and TC10 signaling pathways.
TC10alpha is specifically required for insulin (zeige INS ELISA Kits)-stimulated glucose uptake in adipocytes
the TC10/GAPEX-5 (zeige GAPVD1 ELISA Kits)/Rab5 (zeige RAB5A ELISA Kits) axis mediates insulin (zeige INS ELISA Kits)-stimulated production of PI(3 (zeige PI3 ELISA Kits))P, which regulates trafficking of Glut4 (zeige SLC2A4 ELISA Kits) vesicles
CDK5 (zeige CDK5 ELISA Kits)-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin (zeige INS ELISA Kits)-stimulated GLUT4 (zeige SLC2A4 ELISA Kits) translocation
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14.
ras-like protein TC10
, rho-related GTP-binding protein RhoQ
, Rho small GTPase TC10
, ras homolog gene family, member Q
, RAS-like, family 7, member A
, ras-like protein family member 7A
, ras-related GTP-binding protein TC10
, small GTPase Tc10