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Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Zusätzlich bieten wir Ihnen Rap Guanine Nucleotide Exchange Factor (GEF) 6 Antikörper (42) und viele weitere Produktgruppen zu diesem Protein an.
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local accumulation of PDZGEF at the apical membrane during establishment of epithelial polarity is mediated by electrostatic interactions between positively charged side chains in the PDZ domain and negatively charged phosphatidic acid.
BAG3 (zeige BAG3 Proteine) overexpression increases cell adhesion in Cos7 cells, but not in PDZGEF2 gene knockdown cells indicating that PDZGEF2 is a critical partner for BAG3 (zeige BAG3 Proteine) in regulating cell adhesion
the second PDZ domain from human phosphatase hPTP1E (zeige PTPN13 Proteine) in complex with a C-terminal peptide from the guanine nucleotide exchange factor (zeige RASGRF1 Proteine) RA-GEF-2 has been determined
haplotypes underlying the SPEC2 (zeige CDC42SE2 Proteine)/PDZ-GEF2/acyl-CoA synthetase long-chain family member 6 (zeige ACSL6 Proteine) region are associated with schizophrenia
PDZ-GEF2 plays a critical role in the maturation of adherens junctions.
When males and females were analysed separately, SNP4 (rs31251) in PDZ-GEF2 is associated with schizophrenia in females in Han Chinese.
JAM-A (zeige F11R Proteine) dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A (zeige RAP1A Proteine), which regulates beta1 integrin levels and cell migration.
Study show that double knockout of Rapgef6 in Rapgef2 (zeige RAPGEF2 Proteine)-cKO mice (Rapgef2 (zeige RAPGEF2 Proteine)/6-dKO) results in marked enlargement of the ectopic cortical mass. While Rapgef2 (zeige RAPGEF2 Proteine)-cKO affects late-born neurons only, Rapgef2 (zeige RAPGEF2 Proteine)/6-dKO affects both early-born and late-born neurons in the developing brain.
Rapgef6 deletion mice were impaired in hippocampal and amygdalar function and had reduced spine density and primary dendrite number in pyramidal neurons of the CA3 (zeige CA3 Proteine) hippocampal region.
Data indicate that the testes of RA-GEF-2(-)knockout male mice were significantly smaller than those of wild-type mice and were markedly atrophied as well as hypospermatogenic.
These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras (zeige MRAS Proteine) and Rap1 (zeige TERF2IP Proteine), mediated by RA-GEF-2, in adhesion signaling.
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
Rap guanine nucleotide exchange factor (GEF) 6
, PDZ domain-containing guanine nucleotide exchange factor I
, rap guanine nucleotide exchange factor 6-like
, PDZ domain containing guanine nucleotide exchange factor (GEF) 2
, PDZ domain-containing guanine nucleotide exchange factor 2
, rap guanine nucleotide exchange factor 6
, PDZ domain containing guanine nucleotide exchange factor(GEF)1
, rap guanine nucleotide exchange factor 2