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RBM39 encodes a member of the U2AF65 family of proteins. Zusätzlich bieten wir Ihnen RBM39 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal RBM39 Primary Antibody für IP, WB - ABIN223403
Sotgia, Del Galdo, Casimiro, Bonuccelli, Mercier, Whitaker-Menezes, Daumer, Zhou, Wang, Katiyar, Xu, Bosco, Quong, Aronow, Witkiewicz, Minetti, Frank, Jimenez, Knudsen, Pestell, Lisanti: Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. in The American journal of pathology 2009
Show all 2 Pubmed References
RBM39 is extensively involved in alternative splicing of RNA and helps regulate transcript levels. RBM39 may modulate alternative splicing similarly to U2AF65 (zeige U2AF59 Antikörper) by either directly binding to RNA or recruiting other splicing factors, such as U2AF65 (zeige U2AF59 Antikörper).
The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1 (zeige TIA1 Antikörper), Pcbp1 (zeige PCBP1 Antikörper), and RBM39 stabilizes or increases U2 snRNP (zeige LSM2 Antikörper) recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39-mediated splicing regulation.
This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35 (zeige U2AF1 Antikörper), U2AF65 (zeige U2AF59 Antikörper), RBM39 and SF3b155 (zeige SF3B1 Antikörper), and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells.
mammalian c-Abl (zeige ABL1 Antikörper) plays an important role in steroid hormone receptor (zeige NR4A1 Antikörper)-mediated transcription by regulating RBM39
Knockdown of CAPER expression markedly reduced human breast cancer cell proliferation in both in vitro and in vivo settings. Mechanistically, knockdown of CAPER abrogated the activity of proliferative and protein synthesis pathways.
identify SF3b155 (zeige SF3B1 Antikörper) as the relevant ULM-containing partner of full-length CAPERalpha in human cell extracts.
Data show that CSE1L (zeige CSE1L Antikörper), DIDO1 (zeige DIDO1 Antikörper) and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status.
Increased VEGF(165) expression is secondary to the down-regulation of CAPER-alpha by EWS/FLI-1. CAPER-alpha mediates alternative splicing and controls the shift from VEGF(189) to VEGF(165) .
this study identifies CAPERalpha (RNA binding motif protein 39) as a new transcriptional coregulator for v-Rel (zeige NFkBP65 Antikörper) and reveals an important role in modulating Rel's oncogenic activity.
Analysis of human breast cancer samples revealed that CAPER is overexpressed and undergoes a cytoplasmic-to-nuclear shift during the transition from pre-malignancy to ductal carcinoma in situ
CAPER integrates mitochondrial energy metabolism by coactivating ERR-alpha (zeige ESRRA Antikörper)-Gabpa (zeige GABPA Antikörper) and stress-induced adaptive metabolic responses via NF- kappaB (zeige NFKB1 Antikörper)/c-Myc (zeige MYC Antikörper).
This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X.
RNA binding motif protein 39
, RNA binding motif protein 39, isoform 1
, RNA-binding protein 39
, RNA-binding protein 39-like
, RNA-binding region (RNP1, RRM) containing 2
, coactivator of activating protein-1 and estrogen receptors
, functional spliceosome-associated protein 59
, hepatocellular carcinoma protein 1
, splicing factor HCC1
, RNA-binding motif protein 39
, RNA-binding region-containing protein 2
, coactivator of AP-1 and ERs
, coactivator of activating protein 1 and estrogen receptors
, transcription coactivator CAPER