RAS P21 Protein Activator 3 Proteine (RASA3)

The protein encoded by RASA3 is member of the GAP1 family of GTPase-activating proteins. Zusätzlich bieten wir Ihnen RAS P21 Protein Activator 3 Antikörper (86) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RASA3 22821 Q14644
RASA3 19414 Q60790
Ratte RASA3 RASA3 29372 Q9QYJ2
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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RASA3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu RAS P21 Protein Activator 3 (RASA3) Interaktionspartnern

Human RAS P21 Protein Activator 3 (RASA3) Interaktionspartner

  1. these results support an important role for Rasa3 in PI3K (zeige PIK3CA Proteine)-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading.

  2. the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported.

  3. model in which the Ras GAP (zeige RASA1 Proteine)-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1 (zeige RABGEF1 Proteine), allowing stabilization of the transition state during GTP (zeige AK3 Proteine) hydrolysis initiated by the arginine finger

  4. GAP1IP4BP is an inositol 1,3,4,5-tetrakisphosphate regulated plasma membrane associated Ras and Rap (zeige LRPAP1 Proteine) GAP. Membrane association results from its PH domain binding phosphatidylinositol 4,5-bisphosphate.

Mouse (Murine) RAS P21 Protein Activator 3 (RASA3) Interaktionspartner

  1. these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading.

  2. the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported.

  3. our results indicate that Rasa3 catalytic activity controls Rap1 activation and integrin signaling during megakaryocyte differentiation in mouse.

  4. Expression of RASA3 led to premature platelet activation and markedly reduced the life span of circulating platelets.

  5. Identified is in the scat (severe combined anemia and thrombocytopenia) mouse model a missense mutation (G125V) in the Rasa3 gene, encoding a Ras GTPase activating protein (zeige RASA1 Proteine).

  6. RASA3 plays a critical, conserved, and nonredundant role for RASA3 in vertebrate hematopoiesis.

RAS P21 Protein Activator 3 (RASA3) Protein Überblick

Protein Überblick

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.

Genbezeichner und Symbole assoziert mit RASA3

  • RAS p21 protein activator 3 L homeolog (rasa3.L)
  • RAS p21 protein activator 3 (RASA3)
  • RAS p21 protein activator 3 (rasa3)
  • ras GTPase-activating protein 3 (LOC100433573)
  • RAS p21 protein activator 3 (Rasa3)
  • AI326412 Protein
  • C86362 Protein
  • E130011G04 Protein
  • GAP1IP4BP Protein
  • GAPIII Protein
  • LOC100222817 Protein
  • MGC82492 Protein
  • R-ras gap Protein
  • RASA3 Protein
  • scat Protein

Bezeichner auf Proteinebene für RASA3

RAS p21 protein activator 3 , ras GTPase-activating protein 3-like , GAP1(IP4BP) , GTPase activating protein III , Ins(1,3,4,5)P4-binding protein , inositol 1,3,4,5-tetrakisphosphate-binding protein , ins P4-binding protein , ras GTPase-activating protein 3 , GAPIII activator 3 , R-Ras gap , R-ras RTPase activating protein-3 , Ras GTPase-activating protein III , Ins P4-binding protein , R-Ras GTP activating protein , R-ras GTPase activating protein , RAS p21 protein activator (GTPase activating protein) 3 (Ins(1,3,4,5)P4-binding protein)

GENE ID SPEZIES
446637 Xenopus laevis
452684 Pan troglodytes
698964 Macaca mulatta
100144662 Xenopus (Silurana) tropicalis
100222817 Taeniopygia guttata
100433573 Pongo abelii
100478760 Ailuropoda melanoleuca
100560638 Anolis carolinensis
100580920 Nomascus leucogenys
22821 Homo sapiens
19414 Mus musculus
29372 Rattus norvegicus
476998 Canis lupus familiaris
418736 Gallus gallus
282532 Bos taurus
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