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RAP1GAP encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Zusätzlich bieten wir Ihnen RAP1 GTPase Activating Protein Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal RAP1GAP Primary Antibody für ICC, IF - ABIN4349349
Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. in Molecular & cellular proteomics : MCP 2009
results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity
Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC (zeige CYLD Antikörper)).
Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 (zeige PLK1 Antikörper) in vivo.
kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation
findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells.
Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro.
Downregulation of RAP1GAP in thyroid tumors enhances SRC (zeige SRC Antikörper)-dependent signals that regulate cellular architecture and motility.
Over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion in renal cel carcinoma.
Rap1GAP is a more effective inhibitor of cell-matrix adhesion compared to cell-cell adhesion.
A polycomb (zeige CBX2 Antikörper)-mediated repression of rap1GAP was demonstrated that involves EZH2 (zeige EZH2 Antikörper), a histone methyltransferase in head and neck cancers. It was also shown that the loss of miR (zeige MLXIP Antikörper)-101 expression correlates with EZH2 (zeige EZH2 Antikörper) upregulation and rap1GAP downregulation.
increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin
Plexins are GTPase (zeige RACGAP1 Antikörper)-activating proteins for Rap (zeige LRPAP1 Antikörper) and are activated by induced dimerization
Ca2 (zeige CA2 Antikörper)+-dependent monomer and dimer formation switches CAPRI (zeige RASA4 Antikörper) Protein between Ras GTPase-activating protein (zeige RASA1 Antikörper) (GAP) and RapGAP activities
ERK activation by cAMP does not require RAP1
evidence of differential Krit1 (zeige KRIT1 Antikörper) and Rap1A (zeige RAP1A Antikörper) expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1 (zeige KRIT1 Antikörper), not restricted to vascular endothelial cells.
Rap1 (zeige TERF2IP Antikörper) couples cAMP signaling to a distinct pool of p42 (zeige EPB42 Antikörper)/44MAPK regulating excitability, synaptic plasticity, learning, and memory.
Expression studies show that mr-gef (zeige RAPGEF5 Antikörper) is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).
down-regulation of Rap1 (zeige TERF2IP Antikörper) expression following somatostatin (zeige SST Antikörper) treatment is closely related to the diminished LFA-1 (zeige ITGAL Antikörper) expression
forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling
EGF (zeige EGF Antikörper)-induced activation of GTPase (zeige RACGAP1 Antikörper) Rap1 (zeige TERF2IP Antikörper) was sensitized in NIH3T3/EGFR (zeige EGFR Antikörper)-e3B1 (zeige ABI1 Antikörper) cells.
a proper level of Rap1 is crucial for heart morphogenesis and function.
the direct interaction between Rap1 (zeige TERF2IP Antikörper) and KRIT1 (zeige KRIT1 Antikörper) is required for KRIT1 (zeige KRIT1 Antikörper) function in cardiovascular development
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
rap1 GTPase-activating protein 1
, Rap1, GTPase-activating protein 1
, GTPase activating protein 1
, GTPase activating protein Rap1-GAP
, RAP1, GTPase activating protein 1
, Rap1 GTPase-activating protein 1