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RANBP3 encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. Zusätzlich bieten wir Ihnen RAN Binding Protein 3 Antikörper (78) und RAN Binding Protein 3 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
Computational docking simulation indicates that phosphorylation of RanBP3 at Ser58 could potentially stabilize the association of RanBP3 with importin-alpha through interactions between the phosphate moiety of phospho-Ser58 of RanBP3 and a cluster of basic residues (Arg96 and Lys97 in importin-alpha3) on armadillo repeat 1 of importin-alpha.
RANBP3 regulates melanoma cell proliferation and probably a potential target for molecular targeted therapy.
Results demonstrate that RanBP3L, as a nuclear exporter for BMP-specific Smads, plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation.
RanBP3 is involved in vRNP nuclear export. The function of RanBP3 during vRNP nuclear export is regulated by phosphorylation at Ser58. RanBP3 phosphorylation is modulated by both PI3K (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits) and Ras/ERK (zeige EPHB2 ELISA Kits)/RSK (zeige RPS6KA1 ELISA Kits) pathways in the late phase of viral infection.
Crystal structure of the Ran-binding domain (RBD (zeige CACNA1D ELISA Kits)) from RanBP3 and compare it to RBD (zeige CACNA1D ELISA Kits) structures from RanBP1 (zeige RANBP1 ELISA Kits) and RanBP2 (zeige RANBP2 ELISA Kits) in complex with Ran and CRM1 (zeige XPO1 ELISA Kits).
RanBP3 stimulates export by enhancing the affinity of Crm1 (zeige XPO1 ELISA Kits) for Ran-GTP (zeige AK3 ELISA Kits) and cargo.
A multifunctional domain in CRM1 (exportin 1 (zeige XPO1 ELISA Kits)) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.
RANBP3 phosphorylation links the Ras and PI3-kinase (zeige PIK3CA ELISA Kits) pathways to nucleocytoplasmic transport.
RanBP3 directly recognizes dephosphorylated Smad2 (zeige SMAD2 ELISA Kits)/3, which results from the activity of nuclear Smad (zeige SMAD1 ELISA Kits) phosphatases, and mediates nuclear export of Smad2 (zeige SMAD2 ELISA Kits)/3 in a Ran-dependent manner.
Protein phosphatase PPM1A (zeige PPM1A ELISA Kits) regulates the nuclear export of Smad2 (zeige SMAD2 ELISA Kits)/3 through targeting nuclear exporter RanBP3.
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ran binding protein 3
, RAN binding protein 3
, ran-binding protein 3
, RAN-binding protein-3
, ran-binding protein 3-like