RAD18 Homolog (S. Cerevisiae) Proteine (RAD18)

The protein encoded by RAD18 is highly similar to S. Zusätzlich bieten wir Ihnen RAD18 Antikörper (104) und RAD18 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RAD18 56852 Q9NS91
RAD18 58186 Q9QXK2
Ratte RAD18 RAD18 362412  
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Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Anmelden zum Anzeigen 11 Days
$341.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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RAD18 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Am meisten referenzierte RAD18 Proteine

  1. Human RAD18 Protein expressed in HEK-293 Cells - ABIN2730398 : Zlatanou, Sabbioneda, Miller, Greenwalt, Aggathanggelou, Maurice, Lehmann, Stankovic, Reverdy, Colland, Vaziri, Stewart: USP7 is essential for maintaining Rad18 stability and DNA damage tolerance. in Oncogene 2016 (PubMed)

Weitere Proteine zu RAD18 Homolog (S. Cerevisiae) (RAD18) Interaktionspartnern

Human RAD18 Homolog (S. Cerevisiae) (RAD18) Interaktionspartner

  1. Ubiquitin ligases RNF168 (zeige RNF168 Proteine), RNF169 (zeige RNF169 Proteine), and RAD18 specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 (zeige TP53BP1 Proteine) chromatin recruitment may be activated by RNF168 (zeige RNF168 Proteine) and blocked by RNF169 (zeige RNF169 Proteine) and RAD18.

  2. WRNIP1 (zeige WRNIP1 Proteine) connects PCNA (zeige PCNA Proteine) monoubiquitination with ATMIN (zeige ATMIN Proteine)/ATM (zeige ATM Proteine) to activate ATM (zeige ATM Proteine) signalling in response to replication stress and contribute to the maintenance of genomic stability.

  3. RAD18 polymorphisms are correlated with the side effects of platinum-chemotherapy in Chinese patients with advanced NSCLC.

  4. REV1 (zeige REV1 Proteine) can promote (zeige PCNA Proteine)PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.

  5. USP7 (zeige USP7 Proteine)-mediated de-ubiquitylation protects Rad18 from proteasomal degradation and is necessary for the integrity of the specialized translesion synthesis pathway

  6. RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.

  7. Significantly restored tolerance of RAD18-/- and RNF8 (zeige RNF8 Proteine)-/- cells to camptothecin and olaparib without affecting Rad51 (zeige RAD51 Proteine) focus formation.

  8. these results suggest that miR (zeige MLXIP Proteine)-145 can act as an RAD18 inhibitor and contribute as an important factor in reversing drug resistance after chemotherapy.

  9. We obtained a molecular envelope for Rad18 UBZ-ELRM:linear Ub2 polyubiquitin (zeige UBB Proteine) chains by small-angle X-ray scattering and derived a structural model for the complex.

  10. Rad18 protein ubiquitin-binding zinc fingers domain has alpha-helix and strand beta1 conformation.

Mouse (Murine) RAD18 Homolog (S. Cerevisiae) (RAD18) Interaktionspartner

  1. Somatic hypermutation of immunoglobulin genes (SHM (zeige CNTNAP1 Proteine)) in Rad18 KO mice was similar to wild-type mice, suggesting that Rad18 is dispensable for SHM (zeige CNTNAP1 Proteine).

  2. Rad18 confers DNA damage tolerance and tumor-suppression in a physiological setting.

  3. REV1 promote PCNA (zeige PCNA Proteine) monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.

  4. RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.

  5. RAD18 contributes to maintenance of genomic stability through postreplication repair

  6. Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase

  7. Rad18 suppresses viral infection in a non-specific fashion, probably by targeting incoming DNA.

  8. RAD18 is intrinsically required for the long-term maintenance of spermatogenesis.

RAD18 Protein Überblick

Protein Überblick

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

Genbezeichner und Symbole assoziert mit RAD18

  • RAD18, E3 ubiquitin protein ligase (RAD18)
  • RAD18 E3 ubiquitin protein ligase (Rad18)
  • RAD18 E3 ubiquitin protein ligase (rad18)
  • E3 ubiquitin-protein ligase RAD18 (RAD18)
  • E3 ubiquitin-protein ligase (RAD18)
  • DNA repair protein and ATPase (RAD18)
  • C3HC4-type zinc finger-containing protein (rad18)
  • RAD18, E3 ubiquitin protein ligase (Rad18)
  • 2810024C04Rik Protein
  • DDBDRAFT_0218120 Protein
  • DDBDRAFT_0304878 Protein
  • DDB_0218120 Protein
  • DDB_0304878 Protein
  • DKFZp469H0810 Protein
  • RAD18 Protein
  • Rad18sc Protein
  • RNF73 Protein
  • zgc:55577 Protein

Bezeichner auf Proteinebene für RAD18

E3 ubiquitin-protein ligase RAD18 , RAD18, S. cerevisiae, homolog , RING finger protein 73 , hHR18 , hRAD18 , postreplication repair protein RAD18 , postreplication repair protein hRAD18p , mRAD18Sc , post-replication repair protein RAD18SC , RAD18 homolog (S. cerevisiae) , similar to postreplication repair protein hRAD18p , E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair , Rad18p , hypothetical protein , DNA repair protein and ATPase , SAP DNA-binding domain-containing protein , RAD18 homolog , RAD18-like protein , E3 ubiquitin-protein ligase RAD18-like , e3 ubiquitin-protein ligase RAD18-like

GENE ID SPEZIES
56852 Homo sapiens
58186 Mus musculus
362412 Rattus norvegicus
393106 Danio rerio
416114 Gallus gallus
460144 Pan troglodytes
476544 Canis lupus familiaris
514440 Bos taurus
704708 Macaca mulatta
850430 Saccharomyces cerevisiae S288c
3641637 Candida albicans SC5314
4839641 Scheffersomyces stipitis CBS 6054
8621702 Dictyostelium discoideum AX4
100052645 Equus caballus
100172537 Pongo abelii
100217383 Sus scrofa
100395032 Callithrix jacchus
100473633 Ailuropoda melanoleuca
100591424 Nomascus leucogenys
100720939 Cavia porcellus
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