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RAB4A is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. Zusätzlich bieten wir Ihnen RAB4A, Member RAS Oncogene Family Antikörper (103) und viele weitere Produktgruppen zu diesem Protein an.
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These findings bring attention to the effects of C-terminal carboxylmethylation on RAB (zeige HRB Proteine) GTPases and provide a rationale for targeting ICMT (zeige ICMT Proteine) in the treatment of metastatic cancer
The results contradict the model of feedback activation of Rab5 (zeige RAB5A Proteine) and instead indicate that Rbpt5 is recruited by both Rabex5 (zeige RABGEF1 Proteine) recognizing ubiquitylated cargo and by Rab4 to activate Rab5 (zeige RAB5A Proteine) in a feed-forward manner.
Rab4 expression is up-regulated by laminar shear stress, which contributed to improved vascular endothelial cell autophagy and function.
Together the findings indicate that Arl1 links Rab4-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery.
HRES-1/Rab4 regulates autophagy through promoting the formation of LC3 (zeige MAP1LC3A Proteine)(+) autophagosomes and the preservation of mitochondria.
Data indicate that Rab4 regulates ether-a-go-go-related (zeige KCNH2 Proteine) gene (hERG (zeige KCNH2 Proteine)) channel density via neural precursor cell-expressed developmentally down-regulated protein 4 (zeige NEDD4 Proteine)-2 (Nedd4-2 (zeige NEDD4L Proteine)).
our findings suggest an evolutionarily conserved function of HDPTP-Rab4 in the regulation of endocytic trafficking, cell adhesion and migration.
TBC1D16 (zeige TBC1D16 Proteine) is a GTPase activating protein (zeige RASA1 Proteine) for Rab4A that regulates transferrin receptor recycling and EGFR (zeige EGFR Proteine) trafficking and signaling.
Upregulated expression of rab4, rab5 (zeige RAB5A Proteine), rab7 (zeige RAB7B Proteine) and rab27 (zeige RAB27A Proteine) correlates with antemortem measures of cognitive decline in individuals with mild cognitive impairment and Alzheimer disease.
Thus down- or up-regulation of Rab4A expression or Rab4A function triggered inhibition or increase of procathepsin L secretion respectively.
Insulin (zeige INS Proteine)-dependent Rab4a redistribution, probably reflecting stimulation of vesicle-mediated transport, is inhibited in adipocytes subjected to differentiation in the presence of IL-6 (zeige IL6 Proteine), IL-8 (zeige IL8 Proteine), or IL-15 (zeige IL15 Proteine).
Reduced Akt2 (zeige AKT2 Proteine) leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha (zeige PPARA Proteine).
insulin (zeige INS Proteine) signaling stimulates Rab4 activity, the association of Rab4 with kinesin, the interaction of KIF3 (zeige KIF3A Proteine) with microtubules and this process is mediated by insulin (zeige INS Proteine)-induced PI3-kinase (zeige PIK3CA Proteine)-dependent PKC-lambda activation and participates in GLUT4 (zeige SLC2A4 Proteine) exocytosis
p85alpha protein may play a role in the down-regulation of activated receptors through its temporal control of the GTPase (zeige RACGAP1 Proteine) cycles of Rab5 (zeige RAB5A Proteine) and Rab4
Rab4 is a rate-limiting factor for the recycling of endogenous beta-AR; and augmentation of Rab4-mediated traffic enhances beta-AR function in cardiac myocytes
Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
Sorting of PDGF (zeige PDGFA Proteine) beta-receptors on early endosomes is regulated by sequential activation of PKCalpha (zeige PKCa Proteine) and Rab4a and that this sorting step could constitute a point of cross-talk with other receptors.
Receptor recycling is mediated by AP-1 (zeige JUN Proteine)/clathrin-coated vesicles and regulated by rab4 and rabaptin-5/rabex-5 (zeige RABGEF1 Proteine).
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene.
RAB4A, member RAS oncogene family
, ras-related protein Rab-4A
, Ras-related small GTP binding protein 4