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May be involved in melanosomal transport and docking. Zusätzlich bieten wir Ihnen RAB38, Member RAS Oncogene Family Antikörper (55) und viele weitere Produktgruppen zu diesem Protein an.
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Data suggest RUTBC1/SGSM2 in melanocytes functions as physiological GTPase-activating protein for Rab32/Rab38 in regulation of transport of melanogenic enzymes (tyrosinase, tyrosinase-related protein 1, dopachrome isomerase) into melanosomes.
RHOC (zeige RHOC Proteine) and RAB38 are dispensable for osteoclast function.
Loss of functional Rab38 in the "chocolate" (cht) mouse causes dramatically reduced numbers of melanosomes in adult retinal pigment epithelium, in contrast to the mild phenotype previously shown in skin melanocytes.
Rab38(cht/cht) mice show ocular characteristics reminiscent of human oculocutaneous albinism, as well as iris and RPE (zeige RPE Proteine) thinning.
These results suggest that the genetic abnormality of Rab38 affects multiple lysosome-related organelles, resulting in lung disease in addition to oculocutaneous albinism.
Varp (zeige ANKRD27 Proteine) functions as the Rab32 (zeige RAB32 Proteine)/38 effector that controls trafficking of Tyrp1 (zeige TYRP1 Proteine) in melanocytes.
Rab38 was associated with albuminuria in type 2 diabetes patients. Relative expression of RAB38 was higher in tubuli of patients with diabetic kidney disease compared with control subjects.
Rab38 and its close homolog Rab32 bind to Myosin Vc but not to Myosin Va or Myosin Vb. Binding depends on residues in the switch II region of Rab32 and Rab38 and regions of the Myosin Vc coiled-coil tail domain.
MiR (zeige MLXIP Proteine)-124 significantly decreases the H2O2-induced apoptosis of human hepatic L02 cells by targeting the Rab38 gene and activating the AKT (zeige AKT1 Proteine) pathway.
The expression levels of RAB38 were significantly associated with grade progression as well as prognosis in gliomas. RAB38 is an important prognostic biomarker and potential therapeutic target in gliomas.
BLOC-3 is a Rab32 (zeige RAB32 Proteine) and Rab38 guanine nucleotide exchange factor (zeige RASGRF1 Proteine), with a specific function in the biogenesis of lysosome-related organelles.
that Rab38 and Rab32 (zeige RAB32 Proteine) are the specific factors that direct the ubiquitous machinery to mediate transport from early endosomes to maturing LROs.
Studies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML.
Varp (zeige ANKRD27 Proteine) physically interacts with Rab38, and preferentially binds to the active GTP (zeige AK3 Proteine)-bound form of Rab38 both in vitro and in vivo.
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1.
RAB38, member RAS oncogene family
, ras-related protein Rab-38
, Rab-related GTP-binding protein
, melanoma antigen NY-MEL-1
, Rab38, member of RAS oncogene family
, red eyed dilution
, ruby or red eyed dilution
, small GTP binding protein