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RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).[supplied by OMIM, Nov 2008].. Zusätzlich bieten wir Ihnen RAB21 Antikörper (70) und viele weitere Produktgruppen zu diesem Protein an.
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Human RAB21 Protein expressed in Escherichia coli (E. coli) - ABIN667873
Pellinen, Tuomi, Arjonen, Wolf, Edgren, Meyer, Grosse, Kitzing, Rantala, Kallioniemi, Fässler, Kallio, Ivaska: Integrin trafficking regulated by Rab21 is necessary for cytokinesis. in Developmental cell 2008
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Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 (zeige VAMP8 Proteine) to promote autophagosome-lysosome fusion.
High RAB21 expression is associated with glioma.
Taken together, these data suggest that Rab21 plays a negative role in the EGF (zeige EGF Proteine)-mediated MAPK (zeige MAPK1 Proteine) signaling pathway. Overexpression of Rab21 attenuated EGF (zeige EGF Proteine)-mediated mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) signaling by inducing EGFR (zeige EGFR Proteine) degradation.
Rab21 (and Rab5 (zeige RAB5A Proteine)) associate with the cytoplasmic domains of alpha-integrin chains, and their expression influences the endo/exocytic traffic of integrins. This function of Rab21 is dependent on its GTP (zeige AK3 Proteine)/GDP cycle and proper membrane targeting
Results show that targeted trafficking of integrins to and from the cleavage furrow is required for successful cytokinesis, and that this is regulated by Rab21.
show that TI-VAMP (zeige VAMP7 Proteine) interacts with the Vps9 domain and ankyrin-repeat-containing protein Varp (zeige ANKRD27 Proteine), a guanine nucleotide exchange factor (zeige RASGRF1 Proteine) of the small GTPase (zeige RACGAP1 Proteine) Rab21, through a specific domain herein called the interacting domain.
this novel finding that Rab21 regulates SSTR3 (zeige SSTR3 Proteine) trafficking suggests that Rab21 may play a role in trafficking of other GPCRs.
Mechanistically, p120RasGAP (zeige RASA1 Proteine) interacted with the cytoplasmic domain of integrin alpha-subunits via its GAP domain and competed with Rab21 for binding to endocytosed integrins.
data indicate that Rab21 is a transient component of early and intermediate stages of macropinocytosis, and probably functions in macropinosome maturation before fusing with lysosomal compartments
RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000
ras-related protein Rab-21
, RAB21, member RAS oncogene family