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Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. Zusätzlich bieten wir Ihnen RAB1B, Member RAS Oncogene Family Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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Survival analysis indicates that patients with overexpression of Rab1B or MMP9 (zeige MMP9 Antikörper) have significantly worse overall survival and progression-free survival, but better response to chemotherapy than those with low expression of proteins, and that Rab1B is an independent prognostic factor for colorectal cancer patients.
In these Rab1B-depleted cells, ATG9A (zeige ATG9A Antikörper) accumulated in intermediate membrane structures at autophagosome formation sites. These results indicate that Rab1B is involved in regulating the proper development of autophagosomes.
Authors demonstrate that Rap1b (zeige RAP1B Antikörper) expression is aberrantly increased in GC, resulting in the inhibition of autophagy and apoptosis of GC cells by the PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) pathway.
RAB1B localization to the Golgi.
RAB1B acts as a metastasis suppressor in triple-negative breast cancer by regulating the TGF-beta (zeige TGFB1 Antikörper)/SMAD (zeige SMAD1 Antikörper) signaling pathway and RAB1B may serve as a biomarker of prognosis and response to anti-tumor therapeutics for patients with triple-negative breast cancer.
Our results show, for the first time, that changes in Rab1b levels modulate gene transcription and strongly suggest that a Rab1b increase is required to elicit a secretory response.
The crystal structure of the Rab1b-LepB complex.
results indicate that the cellular localization of MTMR6 (zeige MTMR6 Antikörper) is regulated by Rab1B in the early secretory and autophagic pathways
The detailed molecular reaction mechanism of a complex between human Rab (zeige HRB Antikörper) and RabGAP at the highest possible spatiotemporal resolution and in atomic detail, is described.
Rab1a/b and Rab43, are important for herpes simplex virus 1 virion assembly
Inhibition of PI3K or mTOR (zeige FRAP1 Antikörper) reduced the level of Rap1B (zeige RAP1B Antikörper), which acts downstream of Rheb (zeige RHEB Antikörper) and mTOR (zeige FRAP1 Antikörper). The ubiquitin E3 ligase Smurf2 (zeige SMURF2 Antikörper) mediates the restriction of Rap1B (zeige RAP1B Antikörper) by initiating its degradation.
Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997
RAB1B, member RAS oncogene family
, ras-related protein Rab-1B
, small GTP-binding protein
, RAB1B-like, member RAS oncogene family