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QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Zusätzlich bieten wir Ihnen QPRT Antikörper (63) und QPRT Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human QPRT Protein expressed in Escherichia coli (E. coli) - ABIN667206
Delaney, Hodson, Thakkar, Connor, Sweatman, Kenny, McGill, Holder, Hutton, Haselden, Waterfield: Tryptophan-NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation. in Archives of toxicology 2005
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WT1 (zeige WT1 Proteine) knock-down gave a corresponding decrease in QPRT gene and protein expression. Chromatin-immunoprecipitation revealed WT1 (zeige WT1 Proteine) binding to a conserved site in the first intron of the QPRT gene.
The structural features, size distribution, heat aggregation and ITC studies of the full-length enzyme and the enzyme lacking helix alpha1 strongly suggest that human QPRT acts as a hexamer for cooperative reactant binding via three dimeric subunits and maintaining stability.
Report of the crystal structure of human QPRT bound to its inhibitor phthalic acid (PHT) and kinetic analysis of PHT inhibition of human QPRT.
QPRT is a potential new marker for the immunohistochemical screening of follicular thyroid nodules.
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
, nicotinate-nucleotide pyrophosphorylase (carboxylating)
, nicotinate-nucleotide pyrophosphorylase [carboxylating]
, nicotinate-nucleotide pyrophosphorylase
, quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))