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anti-Pyruvate Dehydrogenase Complex, Component X (PDHX) Antikörper

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. Zusätzlich bieten wir Ihnen Pyruvate Dehydrogenase Complex, Component X Proteine (7) und Pyruvate Dehydrogenase Complex, Component X Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PDHX 8050 O00330
PDHX 27402 Q8BKZ9
PDHX 311254  
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Top anti-Pyruvate Dehydrogenase Complex, Component X Antikörper auf antikoerper-online.de

Showing 10 out of 55 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB Western blot analysis of anti-PDX1 Antibody (T11) (ABIN388774) in NCI-H460 cell line lysates (35 µg/lane).PDX1-T11(arrow) was detected using the purified polyclonal antibody. Western blot analysis of PDX1 (arrow) using PDX1 Antibody (T11) (ABIN388774). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PDX1 gene (Lane 2) (Origene Technologies). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert WB The anti-PDX1 Pab (ABIN388773) is used in Western blot to detect PDX1 in mouse heart tissue lysate. Western blot analysis of PDX1 (arrow) using rabbit polyclonal PDX1 Antibody (C-term) (ABIN388773). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PDX1 gene (Lane 2) (Origene Technologies). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Ziege Unkonjugiert IHC, ELISA, WB ABIN185236 (1µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185389 staining of paraffin embedded Human Pancreas. A) Microwaved antigen retrieval with citrate buffer pH 6 (3µg/ml), HRP-staining. B) Microwaved antigen retrieval with Tris/EDTA buffer pH9 (1µg/ml) , HRP-staining. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
349,82 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.1 mg Anmelden zum Anzeigen 8 bis 10 Tage
357,50 €
Details
Human Ziege Unkonjugiert IHC (p), IHC, ELISA, WB ABIN250349 staining of paraffin embedded Human Pancreas. A) Microwaved antigen retrieval with citrate buffer pH 6 (3?g/ml), HRP-staining. B) Microwaved antigen retrieval with Tris/EDTA buffer pH9 (1?g/ml) , HRP-staining. Western Blot: PDHX Antibody [ABIN250349] - Western blot analysis of Human Pancreas lysate (35ug protein in RIPA buffer) using ABIN250349 (1ug/ml). 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
Details
Human Kaninchen Unkonjugiert EIA, WB 0.1 mg Anmelden zum Anzeigen 8 bis 10 Tage
357,50 €
Details
Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: A431 , B: H1299 C: Hela 10% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
Details
Human Ziege Unkonjugiert IHC, ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
705,40 €
Details
Human Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 12 Days
392,86 €
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cell lines, using PDHX antibody. Immunofluorescence analysis of U2OS cell using PDHX antibody. Blue: DAPI for nuclear staining. 100 μL Anmelden zum Anzeigen 12 Days
261,90 €
Details

PDHX Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Pyruvate Dehydrogenase Complex, Component X Antikörper

  1. Human Polyclonal PDHX Primary Antibody für EIA, WB - ABIN4620452 : Ling, McEachern, Seyda, MacKay, Scherer, Bratinova, Beatty, Giovannucci-Uzielli, Robinson: Detection of a homozygous four base pair deletion in the protein X gene in a case of pyruvate dehydrogenase complex deficiency. in Human molecular genetics 1998 (PubMed)
    Zeige alle 4 Referenzen für ABIN4620452

  2. Human Polyclonal PDHX Primary Antibody für IF, IHC (p) - ABIN388774 : Aral, Benelli, Ait-Ghezala, Amessou, Fouque, Maunoury, Créau, Kamoun, Marsac: Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis. in American journal of human genetics 1998 (PubMed)
    Zeige alle 3 Referenzen für ABIN388774

  3. Human Polyclonal PDHX Primary Antibody für EIA, IHC (p) - ABIN4620453 : Murray, Gilkerson, Capaldi: Quantitative proteomics: the copy number of pyruvate dehydrogenase is more than 10(2)-fold lower than that of complex III in human mitochondria. in FEBS letters 2002 (PubMed)
    Zeige alle 3 Referenzen für ABIN4620453

  4. Human Polyclonal PDHX Primary Antibody für WB - ABIN388773 : Harris, Bowker-Kinley, Wu, Jeng, Popov: Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex. in The Journal of biological chemistry 1997 (PubMed)
    Zeige alle 2 Referenzen für ABIN388773

  5. Human Polyclonal PDHX Primary Antibody für IHC (p), IHC - ABIN250349 : Schild, Ruhs, Beiter, Zügel, Hudemann, Reimer, Krumholz-Wagner, Wagner, Keller, Eder, Krüger, Krüger, Braun, Nieß, Steinacker, Mooren: Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals. in Journal of proteomics 2015 (PubMed)

  6. Human Polyclonal PDHX Primary Antibody für IHC, ELISA - ABIN185389 : Roche, Baker, Yan, Hiromasa, Gong, Peng, Dong, Turkan, Kasten: Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. in Progress in nucleic acid research and molecular biology 2001 (PubMed)

Weitere Antikörper gegen Pyruvate Dehydrogenase Complex, Component X Interaktionspartner

Human Pyruvate Dehydrogenase Complex, Component X (PDHX) Interaktionspartner

  1. We propose testing for the R446* mutation in PDHX as a rapid first screening in Roma infants with metabolic acidosis.

  2. MiR (zeige MLXIP Antikörper)-26a regulates glucose metabolism of colorectal cancer cells by direct targeting PDHX.

  3. New mutation in PDHX gene found in two unrelated patients with Pyruvate dehydrogenase (zeige PDP Antikörper) deficiency.

  4. genetic association with systemic lupus erythematosus to a haplotype between PDHX and CD44 (zeige CD44 Antikörper) was established.

  5. determination that PDH (zeige PDP Antikörper) and complex III exist at a steady-state ratio of 1:100, 1:128 and 1:202 in HeLa cell extracts, fibroblast mitochondria and heart tissue mitochondria, respectively

  6. model of the pyruvate dehydrogenase (zeige PDP Antikörper) complex formed by E2 and E2 plus the E3-binding protein and binding of the E1 and E3 components

  7. specificity of pairing for human E3BP with E3 from its subcomplex structure to be most likely due to conformational rigidity of the binding fragment of the E3-binding domain of E3BP and its exquisite amino acid match with the E3 target interface

  8. A cluster of disease-causing E3 mutations located near the center of the E3BD/E3 interface prevents the efficient recruitment of these E3 variants by E3BP into the PDC (zeige PNKD Antikörper), leading to the dysfunction of the PDC (zeige PNKD Antikörper) catalytic machine.

  9. These data provide an additional case of E3BP deficiency with a unique and previously unreported deletion in the PDHX gene.

  10. Despite the presence of antibodies reactive with PDC (zeige PNKD Antikörper)-E3BP in the majority of primary biliary cirrhosis (PBC (zeige DLAT Antikörper)) patients this self-protein is not a dominant T-cell autoantigen in PBC (zeige DLAT Antikörper).

Mouse (Murine) Pyruvate Dehydrogenase Complex, Component X (PDHX) Interaktionspartner

  1. T1a/podoplanin (zeige PDPN Antikörper) is first expressed in prox 1 (zeige PROX1 Antikörper)-positive lymphatic progenitor cells, with predominant localization in the luminal plasma membrane of lymphatic endothelial cells during later development.

  2. In islet cells both fat and glucose regulate PDK (zeige PDK2 Antikörper) gene and protein expression and indicate that hyperglycemia and hyperlipidemia contribute to the decline in diabetic islet PDH (zeige PDP Antikörper) activity by increasing mRNA and protein expression of PDK (zeige PDK2 Antikörper).

Cow (Bovine) Pyruvate Dehydrogenase Complex, Component X (PDHX) Interaktionspartner

  1. This study showed that the recombinant and bovine E2/E3BP cores bind E3s with a 2:1 stoichiometry, and propose that mammalian PDC (zeige PDC Antikörper) comprises a heterogeneous population of assemblies incorporating a network of E3 cross-bridges above the core surface.

Pyruvate Dehydrogenase Complex, Component X (PDHX) Antigen-Profil

Protein Überblick

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Genbezeichner und Symbole assoziert mit PDHX

  • pyruvate dehydrogenase complex, component X (pdhx) Antikörper
  • pyruvate dehydrogenase complex, component X (PDHX) Antikörper
  • E3-binding protein (pdhX) Antikörper
  • pyruvate dehydrogenase complex, component X (LOC100220979) Antikörper
  • pyruvate dehydrogenase complex, component X (LOC100349815) Antikörper
  • pyruvate dehydrogenase complex, component X (Pdhx) Antikörper
  • pyruvate dehydrogenase protein X component-like (LOC517402) Antikörper
  • Ac1164 Antikörper
  • AI481367 Antikörper
  • DDBDRAFT_0168431 Antikörper
  • DDBDRAFT_0230192 Antikörper
  • DDB_0168431 Antikörper
  • DDB_0230192 Antikörper
  • DLDBP Antikörper
  • E3bp Antikörper
  • MGC86218 Antikörper
  • OPDX Antikörper
  • PDHX Antikörper
  • Pdx1 Antikörper
  • proX Antikörper
  • zgc:66110 Antikörper
  • zgc:85977 Antikörper

Bezeichner auf Proteinebene für PDHX

pyruvate dehydrogenase complex, component X , pyruvate dehydrogenase protein X component, mitochondrial-like , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex , lipoyl-containing pyruvate dehydrogenase complex component X , pyruvate dehydrogenase complex, E3-binding protein subunit , pyruvate dehydrogenase complex, lipoyl-containing component X , pyruvate dehydrogenase protein X component, mitochondrial , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex (E3-binding protein) (proX) , E3-binding protein , E3BP , proX , pyruvate dehydrogenase protein X component

GENE ID SPEZIES
393532 Danio rerio
423154 Gallus gallus
447247 Xenopus laevis
451120 Pan troglodytes
8618072 Dictyostelium discoideum AX4
100059260 Equus caballus
100220979 Taeniopygia guttata
100349815 Oryctolagus cuniculus
100379696 Xenopus (Silurana) tropicalis
100455315 Pongo abelii
100475970 Ailuropoda melanoleuca
100544023 Meleagris gallopavo
100586539 Nomascus leucogenys
8050 Homo sapiens
27402 Mus musculus
311254 Rattus norvegicus
475942 Canis lupus familiaris
517402 Bos taurus
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