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The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. Zusätzlich bieten wir Ihnen PDHA1 Kits (16) und PDHA1 Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PDHA1 Primary Antibody für ICC, IF - ABIN409998
Acin-Perez, Hoyos, Zhao, Vinogradov, Fischman, Harris, Leitges, Wongsiriroj, Blaner, Manfredi, Hammerling: Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Show all 23 Pubmed References
Polyclonal PDHA1 Primary Antibody für WB - ABIN540348
McFate, Mohyeldin, Lu, Thakar, Henriques, Halim, Wu, Schell, Tsang, Teahan, Zhou, Califano, Jeoung, Harris, Verma: Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. in The Journal of biological chemistry 2008
The report PDHA1 as a new component of brainstem-type Lewy bodies in idiopathic PD, DLB and PARK14, the level of PDHA1 protein being significantly decreased in the putamen and substantia nigra of patients with idiopathic Parkinson's disease .
Findings show that serine-threonine-tyrosine kinase 1 (NOK (zeige STYK1 Antikörper)) mediates glycolysis and nuclear pyruvate dehydrogenase (zeige PDP Antikörper) complex (PDC (zeige PNKD Antikörper)) associated histone acetylation.
The association of mitochondrial microphthalmia-associated transcription factor (MITF (zeige MITF Antikörper)) with pyruvate dehydrogenase (PDH (zeige PDP Antikörper)) emerges as an important regulator of mast cell function. Our findings indicate that PDH (zeige PDP Antikörper) could arise as a new target for the manipulation of allergic diseases.
our results show that negative PDHA1 gene expressionis associated with significantly higher cell stemness in prostate cancer cells and reduced protein expression of this gene is associated with shorter clinical outcome in prostate cancers.
oncoprotein HBXIP (zeige HBXIP Antikörper) enhances glucose metabolism reprogramming through suppressing SCO2 (zeige SCO2 Antikörper) and PDHA1 in breast cancer
MPO (zeige MPO Antikörper) and BPI (zeige BPI Antikörper) in CD4 (zeige CD4 Antikörper)(+)T-lymphocytes, and PDHA1 and MRPL42 (zeige MRPL42 Antikörper) in CD8 (zeige CD8A Antikörper)(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.
Phosphorylation at distinct serine and tyrosine residues inhibits PDHA1 through distinct mechanisms to impact active site accessibility.
High HK2 (zeige HK2 Antikörper) expression combined with low phosphorylated PDHA1 expression in the invasive front lesions of colorectal tumors is predictive of tumor aggressiveness and survival.
In the presence of PPARbeta (zeige PPARD Antikörper)/delta, Vpr induced a 3.3-fold increase in PPAR (zeige PPARA Antikörper) response element-driven transcriptional activity, a 1.9-fold increase in PDK4 (zeige PDK4 Antikörper) protein expression, and a 1.6-fold increase in the phosphorylated pyruvate dehydrogenase (zeige PDP Antikörper) subunit E1alpha.
In this study the phenotypes of patients with PDH (zeige PDP Antikörper) deficiency have been divided into three groups of mutations.
The study provired that pyruvate dehydrogenase (zeige PDK2 Antikörper)-deficient mutant caused the retinal drficits in zebrafish.
Systemic Pyruvate Dehydrogenase (zeige PDP Antikörper) Deficiency is associated with Cerebral Developmental Abnormalities.
skeletal muscle IL-6 (zeige IL6 Antikörper) contributes to the regulation of PDH (zeige PDP Antikörper) at rest and during prolonged exercise.
The present findings suggest that IL-6 (zeige IL6 Antikörper) contributes to regulating the PDHa activity and hence carbohydrate oxidation, but the metabolic state of the muscle seems to determine the outcome of this regulation
Liver-specific pyruvate dehydrogenase (zeige PDP Antikörper) complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin (zeige INS Antikörper) sensitivity.
PGC-1alpha (zeige PPARGC1A Antikörper) regulates PDH (zeige PDP Antikörper)-E1alpha protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH (zeige PDP Antikörper) regulation in mouse skeletal muscle in response to fasting and in recovery from exercise.
Embryos carrying predominantly the Pdha1(deletion in exon 8, Deltaex8) allele were found to be globally delayed in development by 9.5 days postcoitus, with resorption occurring over the following several days.
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
pyruvate dehydrogenase E1 alpha 1
, pyruvate dehydrogenase (lipoamide) alpha 1
, pyruvate dehydrogenase alpha subunit
, pyruvate dehydrogenase E1 component subunit alpha
, pyruvate dehydrogenase alpha subunit protein
, pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit
, precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit
, pyruvate dehydrogenase
, pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
, PDHE1-A type I
, pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like
, pyruvate dehydrogenase complex, E1-alpha polypeptide 1
, Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
, pyruvate dehydrogenase E1 component alpha subunit
, pyruvate dehydrogenase E1alpha subunit
, pyruvate dehydrogenase alpha 1