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The protein encoded by PRG4 is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. Zusätzlich bieten wir Ihnen Proteoglycan 4 Antikörper (38) und Proteoglycan 4 Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.
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Lubricin/PRG4 gene expression was increased in medial collateral ligaments after 14 weeks of menopause in adult rabbits.
The mRNA expression levels for lubricin/proteoglycan 4 (PRG4) and tissue inhibitor of metalloproteinase-3 (zeige TIMP3 ELISA Kits) increase with aging.
adult talar cartilage increases both PRG4 release and biosynthetic activity as immediate cellular response to injury
Double knockdown of PRG4 and IL-24 (zeige IL24 ELISA Kits) did not inhibit myxoid liposarcoma (MLS)- cell growth, and single knockdown of PRG4 remarkably increased IL-24 (zeige IL24 ELISA Kits) expression. These results suggest that the growth inhibitory effect of PRG4 knockdown is caused by induction of IL-24 (zeige IL24 ELISA Kits) expression, and PRG4 may contribute to maintain MLS cell growth through repression of IL-24 (zeige IL24 ELISA Kits) expression.
lubricin expression may typify adaptive and neoplastic changes along a pathway toward fibroblast-like synoviocytes
PRG4 binds to TLR2 (zeige TLR2 ELISA Kits) and TLR4 (zeige TLR4 ELISA Kits) and this binding mediates a novel anti-inflammatory role for PRG4.
Cartilage derived from MSCs expressed lubricin protein both in vitro and in vivo
PRG4 is a novel putative ligand for CD44 (zeige CD44 ELISA Kits) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (zeige CD44 ELISA Kits)-mediated mechanism.
The O-glycomap of lubricin, a novel mucin (zeige SLC13A2 ELISA Kits) responsible for joint lubrication, has been identified by site-specific glycopeptide analysis.
Lubricin (Prg4) plays a role in preventing damage to the superficial zone and preservation of chondrocytes. [Review]
5 novel PRG4 mutations and the first case of CACP syndrome resulting from uniparental disomy of chromosome 1.
We speculate that an important role of lubricin in mediating interactions at the cartilage surface is to attach to the cartilage surface and provide a protective coating that maintains the contacting surfaces in a sterically repulsive state.
the intermolecular disulfide-bonded multimeric structure of PRG4 is important for its ability to adsorb to a cartilage surface and function as a boundary lubricant.
The present investigation provides novel insights into the role of the Wnt (zeige WNT2 ELISA Kits) signalling pathways in SZP accumulation in synoviocytes and their roles in the homeostasis of normal joints.
The important role of PRG4 in reducing friction in the tissues and compartments of the knee/stifle joint.
The role of cell surface glycosaminoglycans (GAGs) during TGF-beta1 (zeige TGFB1 ELISA Kits) stimulation of SZP/lubricin/PRG4 in superficial zone articular chondrocytes, was investigated.
Lubricin expression in explant cartilage was also suppressed under hypoxia
SZP production is dependent on the functional cytoskeleton, and Rho GTPases contribute to SZP accumulation by modulating the actions of TGFbeta (zeige TGFB1 ELISA Kits).
the combined treatment with TGF-beta1 (zeige TGFB1 ELISA Kits) and BMP-7 (zeige BMP7 ELISA Kits) or treatment first with TGF-beta1 (zeige TGFB1 ELISA Kits) followed by BMP-7 (zeige BMP7 ELISA Kits) was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.
A variety of monomeric PRG4 proteins and a disulfide-bonded dimer/multimer are secreted by chondrocytes in bovine cartilage explants.
proteoglycan 4 expression and chondrocyte phenotype is invluenced by matrix molecules and alginate-embedded zonal chondrocytes and mesenchymal stem cells
These findings suggest a generalized approach which may be used for molecular resurfacing of tissue surfaces with PRG4 and other lubricating biomolecules.
Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva.
Prg4 is needed for TMJ disc integrity and function and its absence leads to ectopic chondrogenesis and cartilage formation in conjunction with abnormal BMP signaling.
Discs from Prg4 null mice had a significantly smaller mean transverse disc area, with a significantly larger proportion of this area occupied by the nucleus pulposus.
Prg4-expressing cells at the embryonic joint surface serve as a progenitor population for deeper layers of mature articular cartilage. Prg4 is expressed by superficial chondrocytes in young mice but in deeper regions of articular cartilage in older mice.
findings confirm the importance of lubricin in intrasynovial tendon lubrication.
mechanical motion may induce Prg4 expression in the superficial zone of articular cartilage
changes in synovial fluid proteins and PRG4 concentrations upon joint loading are mediated by cells within the joint, and that these changes may be used as quantitative indicators for the intensity and duration of acute joint loading
Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage.
lubricin has roles in boundary lubrication, and cell survival
Blunted PTH (zeige PTH ELISA Kits) anabolic responses in adult Prg4 mutant mice are associated with altered biomechanical impact secondary to joint failure.
The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
, articular superficial zone protein
, bG174L6.2 (MSF: megakaryocyte stimulating factor )
, megakaryocyte stimulating factor
, megakaryocyte-stimulating factor
, superficial zone proteoglycan
, proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)
, MLL septin-like fusion
, p53-responsive gene 4
, proteoglycan 3