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The protein encoded by PTP4A2 belongs to a small class of the protein tyrosine phosphatase (PTP) family. Zusätzlich bieten wir Ihnen Protein tyrosine Phosphatase Type IVA, Member 2 Proteine (15) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal PTP4A2 Primary Antibody für ELISA, WB - ABIN1724901
Hardy, Wong, Muller, Park, Tremblay: Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. in Cancer research 2010
Show all 2 Pubmed References
a critical role for PRL2 phosphatase in mediating Notch (zeige NOTCH1 Antikörper) and c-Kit (zeige KIT Antikörper) signals in early T cell progenitors, is reported.
Oncogenic PRL-2 controls tumor growth by modulating intracellular magnesium levels through binding with the CNNM3 (zeige CNNM3 Antikörper) magnesium transporter.
PTP4A2 plays critical roles in regulating hematopoietic stem cell self-renewal and mediating SCF (zeige KITLG Antikörper)/KIT signaling.
PRL2 promotes Kit-mediated PI3K/Akt (zeige AKT1 Antikörper) signaling by reducing the level of PTEN (zeige PTEN Antikörper) that normally antagonizes the pathway.
Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (zeige PTEN Antikörper) (Phosphatase and Tensin (zeige TNS1 Antikörper) Homologue Deleted on Chromosome 10) and activating Akt (zeige AKT1 Antikörper) protein
Our findings highlight the important role of miR (zeige MLXIP Antikörper)-29c in regulating CRC (zeige CALR Antikörper) EMT (zeige ITK Antikörper) via GSK-3b/b-catenin signaling by targeting GNA13 (zeige GNA13 Antikörper) and PTP4A and provide new insights into the metastatic basis of colorectal cancer
PTP4A2 expression is correlated with overall survival in progestin receptor-positive breast carcinomas.
Results suggest that TRP32 maintains the reduced state of PRL (zeige PRL Antikörper) and thus regulates the biological function of PRL (zeige PRL Antikörper).
Studies indicate that PRL-1 (zeige PLRG1 Antikörper) and PRL-2 and PRL-3 are oncogenes and belong to the few phosphatases that lead to the development of cancer.
Results suggest a model in which PRL-2 promotes cell migration and invasion through an ERK1/2 (zeige MAPK1/3 Antikörper)-dependent signaling pathway.
PRL-2 plays an important role in lung cancer and can be a biomarker of lung cancer, substituting for the function of other PRLs.
Overexpression of the protein tyrosine phosphatase (zeige ACP1 Antikörper) PRL-2 correlates with breast tumor formation and progression.
Mouse pre-B-cells transfected with human PRL-2 had higher growth responses to Epo (zeige EPO Antikörper) or IL-3 (zeige IL-3 Antikörper), shorter cell cycle, less Epo (zeige EPO Antikörper) requirement for survival, more cell migration, less cell adhesion, change to an immature cell morphology, & more Bmi-1 (zeige BMI1 Antikörper) expression.
PRL-2 can promote cell adhesion and invasion activity of human hepatocellular carcinoma cells.
PRL (zeige PRL Antikörper) phosphatases increase cell proliferation by stimulating progression from G1 into S phase
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.
, protein tyrosine phosphatase type IVA 2
, protein tyrosine phosphatase 4a2
, protein tyrosine phosphatase type IVA, member 2
, protein-tyrosine phosphatase 4a2
, protein-tyrosine phosphatase of regenerating liver 2
, phosphatase of regenerating liver 2
, protein tyrosine phosphatase IVA
, protein tyrosine phosphatase IVA2