Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteine (PPM1A)

The protein encoded by PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. Zusätzlich bieten wir Ihnen Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Antikörper (110) und Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PPM1A 19042 P49443
PPM1A 5494 P35813
PPM1A 24666 P20650
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Showing 10 out of 18 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
366,67 €
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HOST_Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
293,33 €
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HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
328,90 €
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HOST_Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
178,57 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details

PPM1A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Human , , , ,
, , ,
Rat (Rattus)

Weitere Proteine zu Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Interaktionspartnern

Mouse (Murine) Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Interaktionspartner

  1. findings demonstrate a novel regulatory circuit in which STING and TBK1 (zeige TBK1 Proteine) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (zeige TBK1 Proteine)

  2. the studies presented here position PPM1A as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions

  3. a nuclear envelope-localized mechanism of inactivating TGF-beta (zeige TGFB1 Proteine) signaling in which MAN1 (zeige LEMD3 Proteine) competes with transcription factors for binding to Smad2 (zeige SMAD2 Proteine) and Smad3 (zeige SMAD3 Proteine) and facilitates their dephosphorylation by PPM1A.

  4. Although a non-myristoylated mutation (G2A (zeige GPR132 Proteine)) of PPM1A and PPM1B (zeige PPM1B Proteine) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (zeige GRK4 Proteine).

  5. we found that PPM1A mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A protein

  6. Protein phosphatase PPM1A regulates the nuclear export of Smad2 (zeige SMAD2 Proteine)/3 through targeting nuclear exporter RanBP3 (zeige RANBP3 Proteine).

  7. Ppm1a, through suppressing Smad2 (zeige SMAD2 Proteine) signaling, plays a critical role in re-epithelialization during wound healing

  8. Molecular cloning and expression analysis of MPP alpha-2, a novel transcript detected in a differential screen of pituitary libraries (MPPalpha 2)

  9. Protein phosphatase 1alpha is required for lung growth and morphogenesis.

Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Interaktionspartner

  1. establish PPM1A as a novel repressor of the SMAD3 (zeige SMAD3 Proteine) pathway in renal fibrosis

  2. Report a tumor-suppressive function of PPM1A and an independent relationship to Smad4 (zeige SMAD4 Proteine) in pancreatic ductal adenocarcinoma.

  3. hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha between the active and inactive states

  4. In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A; P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.

  5. findings demonstrate a novel regulatory circuit in which STING and TBK1 (zeige TBK1 Proteine) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (zeige TBK1 Proteine)

  6. The TGF-beta (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation.

  7. Loss of PPM1A is associated with the development of tumor invasion in bladder cancer patients.

  8. PPM1A is a RelA (zeige NFkBP65 Proteine) phosphatase that regulates NF-kappaB (zeige NFKB1 Proteine) activity and that PPM1A has tumor suppressor-like activity.

  9. a nuclear envelope-localized mechanism of inactivating TGF-beta (zeige TGFB1 Proteine) signaling in which MAN1 (zeige LEMD3 Proteine) competes with transcription factors for binding to Smad2 (zeige SMAD2 Proteine) and Smad3 (zeige SMAD3 Proteine) and facilitates their dephosphorylation by PPM1A.

  10. phosphatase activity toward phosphopeptide substrates by PP2Calpha and Wip1 (zeige PPM1D Proteine) requires the binding of a Mg(2 (zeige MUC7 Proteine))+ ion to the low-affinity site.

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Genbezeichner und Symbole assoziert mit PPM1A

  • protein phosphatase 1A-like (LOC100738389)
  • protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1Aa (ppm1aa)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1Bb (ppm1bb)
  • 2310003C21Rik Protein
  • 2900017D14Rik Protein
  • AI427932 Protein
  • AU017636 Protein
  • fc18g04 Protein
  • MMPa-2 Protein
  • MPPa-1 Protein
  • pp2c-alpha Protein
  • Pp2c1 Protein
  • pp2ca Protein
  • pp2ca2 Protein
  • pp2calpha Protein
  • ppm1a Protein
  • wu:fc18g04 Protein
  • zgc:92329 Protein

Bezeichner auf Proteinebene für PPM1A

Mpp alpha , PP2C-alpha , protein phosphatase 1A , protein phosphatase 2C isoform alpha , protein phosphatase IA , protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform , IA , Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform , Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform , protein phosphatase 1A, magnesium dependent, alpha isoform , protein phosphatase 2C alpha , protein phosphatase type 2C alpha 2 , protein phosphatase 1A, magnesium dependent, alpha

GENE ID SPEZIES
100738389 Sus scrofa
19042 Mus musculus
5494 Homo sapiens
24666 Rattus norvegicus
380058 Xenopus laevis
423525 Gallus gallus
480344 Canis lupus familiaris
281994 Bos taurus
100009431 Oryctolagus cuniculus
100734826 Cavia porcellus
30704 Danio rerio
100003481 Danio rerio
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