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The protein encoded by PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. Zusätzlich bieten wir Ihnen Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteine (18) und Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Kits (10) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 110 products:
Human Monoclonal PPM1A Primary Antibody für FACS, ELISA - ABIN969556
Sun, Yu, Dotti, Shen, Tan, Savoldo, Pass, Chu, Zhang, Lu, Fu, Lin, Yang: PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. in Cellular signalling 2008
Show all 2 Pubmed References
Human Monoclonal PPM1A Primary Antibody für IP, ELISA - ABIN316118
Juhasz, Markel, Gaur, Liu, Lu, Jiang, Wu, Antony, Wu, Melillo, Meitzler, Haines, Butcher, Roy, Doroshow: NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. in The Journal of biological chemistry 2017
findings demonstrate a novel regulatory circuit in which STING and TBK1 (zeige TBK1 Antikörper) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (zeige TBK1 Antikörper)
the studies presented here position PPM1A as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions
a nuclear envelope-localized mechanism of inactivating TGF-beta (zeige TGFB1 Antikörper) signaling in which MAN1 (zeige LEMD3 Antikörper) competes with transcription factors for binding to Smad2 (zeige SMAD2 Antikörper) and Smad3 (zeige SMAD3 Antikörper) and facilitates their dephosphorylation by PPM1A.
Although a non-myristoylated mutation (G2A (zeige GPR132 Antikörper)) of PPM1A and PPM1B (zeige PPM1B Antikörper) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (zeige GRK4 Antikörper).
we found that PPM1A mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A protein
Protein phosphatase PPM1A regulates the nuclear export of Smad2 (zeige SMAD2 Antikörper)/3 through targeting nuclear exporter RanBP3 (zeige RANBP3 Antikörper).
Ppm1a, through suppressing Smad2 (zeige SMAD2 Antikörper) signaling, plays a critical role in re-epithelialization during wound healing
Molecular cloning and expression analysis of MPP alpha-2, a novel transcript detected in a differential screen of pituitary libraries (MPPalpha 2)
Protein phosphatase 1alpha is required for lung growth and morphogenesis.
establish PPM1A as a novel repressor of the SMAD3 (zeige SMAD3 Antikörper) pathway in renal fibrosis
Report a tumor-suppressive function of PPM1A and an independent relationship to Smad4 (zeige SMAD4 Antikörper) in pancreatic ductal adenocarcinoma.
hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha between the active and inactive states
In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A; P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.
The TGF-beta (zeige TGFB1 Antikörper)/Smad (zeige SMAD1 Antikörper) signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation.
Loss of PPM1A is associated with the development of tumor invasion in bladder cancer patients.
PPM1A is a RelA (zeige NFkBP65 Antikörper) phosphatase that regulates NF-kappaB (zeige NFKB1 Antikörper) activity and that PPM1A has tumor suppressor-like activity.
phosphatase activity toward phosphopeptide substrates by PP2Calpha and Wip1 (zeige PPM1D Antikörper) requires the binding of a Mg(2 (zeige MUC7 Antikörper))+ ion to the low-affinity site.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
, protein phosphatase 1A
, protein phosphatase 2C isoform alpha
, protein phosphatase IA
, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
, Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform
, Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform
, protein phosphatase 1A, magnesium dependent, alpha isoform
, protein phosphatase 2C alpha
, protein phosphatase type 2C alpha 2
, protein phosphatase 1A, magnesium dependent, alpha