anti-Protein Kinase, CGMP-Dependent, Type I (PRKG1) Antikörper

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). Zusätzlich bieten wir Ihnen Protein Kinase, CGMP-Dependent, Type I Kits (22) und Protein Kinase, CGMP-Dependent, Type I Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PRKG1 54286  
PRKG1 5592 Q13976
PRKG1 19091 P0C605
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Top anti-Protein Kinase, CGMP-Dependent, Type I Antikörper auf antikoerper-online.de

Showing 10 out of 70 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB The anti-cGKI beta Pab (ABIN392536) is used in Western blot to detect cGKI beta in 293 cell lysate (Lane 1) and mouse small intestine tissue lysate (Lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
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Rind (Kuh) Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
360,85 €
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Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: JC B: BCL-1 7.5% SDS PAGE antibody diluted at 1:10000 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
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Fledermaus Kaninchen Unkonjugiert IHC (p), WB Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with PRKG1 antibody ABIN307178 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
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Human Kaninchen Unkonjugiert IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human endometrial cancer, using cGK1, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: NIH-3T3 B: JC 7.5% SDS PAGE antibody diluted at 1:2000 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
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Human Maus Unkonjugiert EIA, IHC (p), WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
583,00 €
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Human Maus Unkonjugiert IF, IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
583,17 €
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Human Maus Unkonjugiert IF, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKG1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKG1. Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-PRKG1 mouse monoclonal antibody. (ABIN2453517, Dilution 1:50) 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
366,67 €
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Rind (Kuh) Kaninchen Unkonjugiert WB 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
385,00 €
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PRKG1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Rat (Rattus)


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Human
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Mouse (Murine)


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Am meisten referenzierte anti-Protein Kinase, CGMP-Dependent, Type I Antikörper

  1. Human Polyclonal PRKG1 Primary Antibody für IHC (p), WB - ABIN392536 : Orstavik, Natarajan, Taskén, Jahnsen, Sandberg: Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1). in Genomics 1997 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen Protein Kinase, CGMP-Dependent, Type I Interaktionspartner

Human Protein Kinase, CGMP-Dependent, Type I (PRKG1) Interaktionspartner

  1. These affinity and activation measurements show that beta-phenyl-1,N2-ethenoguanosine 3',5'-monophosphate (PET-cGMP) is most selective for PKG I, whereas 8-(4-chlorophenylthio)guanosine-3'-5'-cyclic monophosphate (8-pCPT-cGMP) is most selective for PKG II.

  2. Hence, SO2 exerted its vasodilatory effects at least partly by promoting disulfide-dependent dimerization of sGC (zeige SGCB Antikörper) and PKG, resulting in an activated sGC (zeige SGCB Antikörper)/cGMP/PKG pathway in blood vessels. These findings revealed a new mode of action and mechanisms by which SO2 regulated the vascular tone.

  3. these data indicate PKG as an intermediary in EGFR (zeige EGFR Antikörper)-mediated cell death, likely via apoptotic pathway.

  4. The heterozygous c.530G>A:p.Arg177Gln PRKG1 variant was associated with early-onset thoracic aortic aneurysm and dissection in a Spanish family.

  5. cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo (zeige C9orf3 Antikörper), cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B.

  6. Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing

  7. The C42-C42' disulfide bond dramatically stabilizes PRKG1.

  8. Study of genetic heterogeneity in systemic lupus erythematosus, the top associations in European ancestry were protein kinase (zeige CDK7 Antikörper), cyclic GMP (zeige NT5C2 Antikörper)-dependent, type I (PRKG1) rs7897633 (P(Meta) = 2.75 x 10(-8)) and purine nucleoside phosphorylase (PNP (zeige NP Antikörper)) rs1049564 (P(Meta) = 1.24 x 10(-7)).

  9. Expression levels of miR (zeige MLXIP Antikörper)-517a-3p and its target mRNA PRKG1 were inversely correlated in NK cells before and after obstetric delivery.

  10. miR (zeige MLXIP Antikörper)-20a expression is up-regulated in response to hypoxia in both mouse and human pulmonary arterial smooth muscle cells

Cow (Bovine) Protein Kinase, CGMP-Dependent, Type I (PRKG1) Interaktionspartner

  1. NADPH regulation of PKG1-alpha dimerization may contribute to vascular responses to hypoxia that are associated with changes in NADPH redox.

  2. The data suggest that PKG-I expression is subjected to post-transcriptional regulation in VSMC through the 3'UTR (zeige UTS2R Antikörper) of its mRNA.

  3. Report roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia.

  4. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication

  5. purified cGMP kinase signaling complex contained alpha-actin (zeige ACTA2 Antikörper), calponin H1, and phospholamban (zeige PLN Antikörper)

  6. studies suggest that cross-activation of PKA in response to iNOS expression by inflammatory mediators downregulates cGMP-dependent protein kinase expression in bovine aortic vascular smooth muscle cells

  7. Demonstrate a novel PKG-dependent pathway by which the Rac1/Pak1 (zeige PAK1 Antikörper) pathway is activated.

  8. cGMP-dependent protein kinase expression is regulated by soluble guanylyl cyclase in vascular smooth muscle cells

  9. cGMP-dependent protein kinase (zeige CDK7 Antikörper) Ibeta binds to TFII-I (zeige GTF2I Antikörper) and IRAG (zeige MRVI1 Antikörper) through a common interaction motif

  10. cGMP binding destabilizes the N-terminus of cGMP-dependent protein kinase I alpha isozyme at the hinge region, centered around residue 77, while the C-terminus is protected from degradation.

Mouse (Murine) Protein Kinase, CGMP-Dependent, Type I (PRKG1) Interaktionspartner

  1. analysis of the role of binding interface with protein kinase G-Ialpha leucine zipper in vascular function

  2. Brown adipose tissue, via Nox4-derived hydrogen peroxide, induces cyclic GMP-dependent protein kinase G type-1alpha activation, resulting in reduced vascular contractility.

  3. disulfide formation at Cys (zeige DNAJC5 Antikörper)(43) does not directly activate PKGIalpha, and the C43S-mutant PKGIalpha has a higher Ka for cGMP. Results highlight that mutant enzymes should be carefully biochemically characterized before making in vivo inferences.

  4. PKG Ialpha disulfide formation triggers cardiac injury, and this initiation of maladaptive signaling can be blocked by pharmacological therapies that elevate cGMP, which binds kinase to limit its oxidation.

  5. Cyclic GMP kinase (zeige GUK1 Antikörper) deletion causes iron deficiency anemia, duodenal ulcers, and bleeding in the knockout mice.

  6. Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing

  7. cGMP/protein kinase (zeige CDK7 Antikörper) G signaling suppresses Itpr1 (zeige ITPR1 Antikörper) phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3 (zeige CNGA3 Antikörper)-deficient mice.

  8. Data show that cGMP-dependent kinase (cGK-Ialpha) knockdown partially rescued TNF-alpha (zeige TNF Antikörper)-induced decrease in 42-kDa cGMP-dependent protein kinase-anchoring protein (GKAP42 (zeige GKAP1 Antikörper)) and impairment of insulin (zeige INS Antikörper) signals.

  9. miR (zeige MLXIP Antikörper)-20a expression is up-regulated in response to hypoxia in both mouse and human pulmonary arterial smooth muscle cells

  10. These findings characterize PKG as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.

Rabbit Protein Kinase, CGMP-Dependent, Type I (PRKG1) Interaktionspartner

  1. The novel cGMP/PKG/ROS (zeige ROS1 Antikörper)/calmodulin (zeige CALM Antikörper)/CaMKII (zeige CAMK2G Antikörper) signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.

Protein Kinase, CGMP-Dependent, Type I (PRKG1) Antigen-Profil

Protein Überblick

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Genbezeichner und Symbole assoziert mit PRKG1

  • protein kinase, cGMP-dependent, type Ia (prkg1a) Antikörper
  • protein kinase, cGMP-dependent, type I (PRKG1) Antikörper
  • protein kinase, cGMP-dependent, type I (prkg1) Antikörper
  • protein kinase, cGMP-dependent, type 1 (Prkg1) Antikörper
  • protein kinase, cGMP-dependent, type I (Prkg1) Antikörper
  • 1 Antikörper
  • AW125416 Antikörper
  • cGK Antikörper
  • cGK 1 Antikörper
  • cGK1 Antikörper
  • CGKI Antikörper
  • cGKI-alpha Antikörper
  • cGKI-beta Antikörper
  • Gm19690 Antikörper
  • PKG Antikörper
  • Pkgi Antikörper
  • prkg1 Antikörper
  • Prkg1b Antikörper
  • Prkg1beta Antikörper
  • Prkgr1b Antikörper
  • zgc:63955 Antikörper

Bezeichner auf Proteinebene für PRKG1

cGMP-dependent protein kinase 1 , protein kinase, cGMP-dependent, type I , cGMP-dependent protein kinase 1, beta isozyme , cGMP-dependent protein kinase I alpha , cGK I alpha , cGMP-dependent protein kinase 1-like , cGMP dependent protein kinase type 1 , protein kinase, cGMP-dependent, regulatory, type I, beta , CGK 1 alpha , cGK 1 beta , cGK1 , cGKI-alpha , cGMP-dependent protein kinase 1, alpha isozyme , cGMP-dependent protein kinase I , cGK 1 , PKG1 alpha , cGMP-dependent protein kinase type 1 alpha , cGMP-dependent protein kinase type I beta

GENE ID SPEZIES
394005 Danio rerio
744467 Pan troglodytes
100049290 Oryzias latipes
100388016 Callithrix jacchus
54286 Rattus norvegicus
5592 Homo sapiens
282004 Bos taurus
19091 Mus musculus
100008694 Oryctolagus cuniculus
733640 Sus scrofa
423682 Gallus gallus
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