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The protein encoded by PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). Zusätzlich bieten wir Ihnen PICK1 Antikörper (141) und PICK1 Kits (28) und viele weitere Produktgruppen zu diesem Protein an.
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PICK1 is a cargo-specific endocytic accessory protein required for efficient, activity-dependent AMPAR endocytosis.
Our results demonstrate that downregulation of PICK1 elicited by miR (zeige MLXIP Proteine)-210-3p overexpression activates the TGF-b pathway, which further promotes bone metastasis in PCa (zeige FLVCR1 Proteine), indicating that the miR (zeige MLXIP Proteine)- 210-3p/PICK1/TGF-b signalling axis plays an important role in PCa (zeige FLVCR1 Proteine) bone metastasis.
This study defines a novel mechanism whereby elevated [Ca(2 (zeige CA2 Proteine)+)] induced by NMDA receptor activation modulates Ago2 (zeige EIF2C2 Proteine) and miRNA activity via PICK1. Our work suggests a Ca(2 (zeige CA2 Proteine)+)-dependent process to regulate miRNA activity in neurons in response to the induction of long-term depression.
We propose that PICK1 negatively regulates neoplastic infiltration of astrocytic tumors and that manipulation of PICK1 is an attractive possibility for therapeutic intervention
PICK1 domain ACT links PICK1-associated vesicles to a motility factor, likely myosin, but, contrary to previous reports, PICK1 neither binds nor inhibits Arp2 (zeige ACTR2 Proteine)/3 complex.
Unlike accessory domains in other BAR domain proteins, the positioning of the PDZ domains is flexible, enabling PICK1 to perform long-range, dynamic scaffolding of membrane-associated proteins.
Data indicate three principal binding modes can account for protein interacting with C-kinase 1 (PICK1) PDZ domains binding specificity.
PICK1 promotes Ago2 (zeige EIF2C2 Proteine) localization at endosomal compartments in neuronal dendrites and inhibits Ago2 (zeige EIF2C2 Proteine) function in translational repression following neuronal stimulation.
These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells.
C-terminal domain of ICA69 (zeige ICA1 Proteine) interacts with PICK1 and acts on trafficking of PICK1-PKCalpha (zeige PKCa Proteine) complex and cerebellar plasticity.
Ca(2 (zeige CA2 Proteine)+) influx through ASIC1 (zeige ACCN2 Proteine) mediates chronic hypoxia and ET-1 (zeige EDN1 Proteine)-induced NFATc3 (zeige NFATC3 Proteine) nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 (zeige NFATC3 Proteine) nuclear import.
a dual role of PICK1 in regulating macrophage polarization
This study demonstrated that d-serine provent the behavioral deficits in adult Pick1 knockout mice.
PICK1 is an important regulator of P2Y6R (zeige P2RY6 Proteine) expression and microglial phagocytosis.
knocking-out PICK1 gene casts the neuroprotection effect by reducing ASICs current and the calcium transients in OGD (zeige FGFR1 Proteine)-Rep neuronal cells
ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
results indicate that PICK1 is a crucial regulator in glutathione homeostasis and may play important roles in oxidative stress.
In cultured neurons, PICK1 deletion increases surface AMPARs and blocks Abeta42-induced reduction in surface GluA2 (zeige GRIA2 Proteine).
This study demonstrated that PICK1 functions in vesicle biogenesis and is necessary to maintain normal vesicle numbers and size.
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
, protein interacting with C kinase 1
, protein kinase C-alpha-binding protein
, protein kinase C, alpha binding protein
, protein that interacts with C kinase 1
, protein interacting with PRKCA 1