Protein C Receptor, Endothelial Proteine (PROCR)

The protein encoded by PROCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. Zusätzlich bieten wir Ihnen PROCR Antikörper (173) und PROCR Kits (57) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PROCR 10544 Q9UNN8
PROCR 362248 Q4V8I1
PROCR 19124 Q64695
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Top PROCR Proteine auf antikoerper-online.de

Showing 10 out of 34 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_HEK-293 Cells Human His tag Human PROCR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
360,00 €
Details
HOST_Human Cells Human His tag 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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HOST_Human Cells Maus Fc Tag 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
525,00 €
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HOST_Human Cells Cynomolgus Fc Tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
525,00 €
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HOST_Human Cells Ratte His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
525,00 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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PROCR Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , , ,
, , ,
Rat (Rattus) , ,

Mouse (Murine) , ,
, ,

Am meisten referenzierte PROCR Proteine

  1. Human PROCR Protein expressed in HEK-293 Cells - ABIN2181663 : Fukudome, Esmon: Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. in The Journal of biological chemistry 1994 (PubMed)
    Zeige alle 3 Referenzen für 2181663

  2. Human PROCR Protein expressed in Wheat germ - ABIN1316360 : Fink, Busch, Bourgeois, Schwarz, Wolf, Zirlik, Peter, Bode, von Zur Muhlen: Mac-1 directly binds to the endothelial protein C-receptor: a link between the protein C anticoagulant pathway and inflammation? in PLoS ONE 2013 (PubMed)
    Zeige alle 3 Referenzen für 1316360

  3. Cynomolgus PROCR Protein expressed in Human Cells - ABIN2010024 : Mosnier, Zlokovic, Griffin: The cytoprotective protein C pathway. in Blood 2007 (PubMed)

Weitere Proteine zu Protein C Receptor, Endothelial (PROCR) Interaktionspartnern

Human Protein C Receptor, Endothelial (PROCR) Interaktionspartner

  1. EPCR occupancy recruits G-protein coupled receptor kinase 5 (zeige GRK5 Proteine), thereby inducing beta-arrestin-2 (zeige ARRB2 Proteine) biased PAR1 (zeige MARK2 Proteine) signaling by both APC (zeige APC Proteine) and thrombin (zeige F2 Proteine). In

  2. EPCR polymorphisms may be associated with increased risk of sepsis, but this has no effect on the release of soluble EPCR in patients with sepsis.

  3. Elevated endothelium-related mediators (vWF (zeige VWF Proteine), E-selectin (zeige SELE Proteine) and EPCR) appear to participate in the development of pancreatic necrosis and may be a potential indicator of overall prognosis.

  4. The results showed that AS-IV could significantly inhibit PMA-induced EPCR shedding.

  5. CORM-2 protects human umbilical vein endothelial cells from lipopolysaccharide-induced injury, by way of suppressing NF-kappaB (zeige NFKB1 Proteine) activity, which downregulates TM and EPCR mRNAs. It also decreases MMP-2 (zeige MMP2 Proteine) expression and prevents the shedding of TM and EPCR from the surface of endothelial cells, so as to preserve their protective effect.

  6. This study shows that ICAM-1 (zeige ICAM1 Proteine) is a coreceptor for a subset of EPCR-binding Plasmodium falciparum parasites and provides the first evidence of how EPCR and ICAM-1 (zeige ICAM1 Proteine) interact to mediate parasite binding to both resting and TNF-alpha (zeige TNF Proteine)-activated primary brain and lung endothelial cells.

  7. This study demonstrates that impaired EPCR function can be detected by thrombin (zeige F2 Proteine) generation and clot (zeige TXNDC17 Proteine) lysis assays on cells expressing thrombomodulin (zeige THBD Proteine) and EPCR. Deficiency in EPCR has procoagulant effects that lead to a delay in clot (zeige TXNDC17 Proteine) lysis.

  8. Observations that binding of P. falciparum erythrocyte membrane protein 1 to EPCR results in an acquired functional protein C system deficiency support the new paradigm that EPCR plays a central role in the pathogenesis of severe malaria. [review]

  9. data suggest that either the lack of the protective EPCR 4678C allele or the presence of EPCR 4600G allele may be associated with earlier development of thrombosis.

  10. These data suggest that 6936A/G polymorphism is a risk factor for deep venous thrombosis and is associated with elevated plasma levels of soluble EPCR, while 4678G/C polymorphism plays a role in protection against deep venous thrombosis.

Mouse (Murine) Protein C Receptor, Endothelial (PROCR) Interaktionspartner

  1. PROCR thus does not globally inhibit Th17 responses but could be targeted to selectively inhibit proinflammatory Th17 cells.

  2. Thrombin (zeige F2 Proteine)-PAR1 (zeige F2R Proteine) signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC (zeige FUT1 Proteine)) mobilization. aPC (zeige APC Proteine)-EPCR-PAR1 (zeige F2R Proteine) signaling promotes HSC (zeige FUT1 Proteine) retention in bone marrow.

  3. impaired EPCR/protein C (zeige PROC Proteine)-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  4. sPLA2 (zeige PLA2G2A Proteine)-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C (zeige PROC Proteine) activation.

  5. HSCs appear to maintain expression of CD201 after hematopoietic injury when Kit expression is downregulated.

  6. The protein C (zeige PROC Proteine) receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS (zeige TLR4 Proteine))-regulated gene expression.

  7. Data indicate that endothelial protein C receptor (EPCR) binding enhances FVIIa hemostatic activity in vivo.

  8. protein C (zeige PROC Proteine) receptor (Procr), a novel Wnt (zeige WNT2 Proteine) target in the mammary gland, marks a unique population of multipotent mouse mammary stem cells

  9. FVIIa binding to EPCR leads to a barrier protective effect in vivo

  10. Piperlonguminine might have potential as an anti-sEPCR shedding reagent against sepsis-mediated EPCR shedding.

PROCR Protein Überblick

Protein Überblick

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.

Genbezeichner und Symbole assoziert mit PROCR

  • protein C receptor, endothelial (EPCR) (PROCR)
  • protein C receptor, endothelial (PROCR)
  • protein C receptor, endothelial (Procr)
  • AI325044 Protein
  • Ccca Protein
  • Ccd41 Protein
  • Epcr Protein
  • PROCR Protein

Bezeichner auf Proteinebene für PROCR

protein C receptor, endothelial (EPCR) , APC receptor , CD201 antigen , activated protein C receptor , cell cycle, centrosome-associated protein , centrocyclin , endothelial protein C receptor , endothelial cell protein C receptor , CD antigen CD201 , centrosomal protein CCD41 , endothelial cell protein C/activated protein C

GENE ID SPEZIES
458198 Pan troglodytes
10544 Homo sapiens
362248 Rattus norvegicus
19124 Mus musculus
100731547 Cavia porcellus
654289 Sus scrofa
282005 Bos taurus
485848 Canis lupus familiaris
424867 Gallus gallus
101115814 Ovis aries
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