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The protein encoded by PROCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. Zusätzlich bieten wir Ihnen PROCR Antikörper (173) und PROCR Proteine (34) und viele weitere Produktgruppen zu diesem Protein an.
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EPCR occupancy recruits G-protein coupled receptor kinase 5 (zeige GRK5 ELISA Kits), thereby inducing beta-arrestin-2 (zeige ARRB2 ELISA Kits) biased PAR1 (zeige MARK2 ELISA Kits) signaling by both APC (zeige APC ELISA Kits) and thrombin (zeige F2 ELISA Kits). In
EPCR polymorphisms may be associated with increased risk of sepsis, but this has no effect on the release of soluble EPCR in patients with sepsis.
Elevated endothelium-related mediators (vWF (zeige VWF ELISA Kits), E-selectin (zeige SELE ELISA Kits) and EPCR) appear to participate in the development of pancreatic necrosis and may be a potential indicator of overall prognosis.
The results showed that AS-IV could significantly inhibit PMA-induced EPCR shedding.
CORM-2 protects human umbilical vein endothelial cells from lipopolysaccharide-induced injury, by way of suppressing NF-kappaB (zeige NFKB1 ELISA Kits) activity, which downregulates TM and EPCR mRNAs. It also decreases MMP-2 (zeige MMP2 ELISA Kits) expression and prevents the shedding of TM and EPCR from the surface of endothelial cells, so as to preserve their protective effect.
This study shows that ICAM-1 (zeige ICAM1 ELISA Kits) is a coreceptor for a subset of EPCR-binding Plasmodium falciparum parasites and provides the first evidence of how EPCR and ICAM-1 (zeige ICAM1 ELISA Kits) interact to mediate parasite binding to both resting and TNF-alpha (zeige TNF ELISA Kits)-activated primary brain and lung endothelial cells.
This study demonstrates that impaired EPCR function can be detected by thrombin (zeige F2 ELISA Kits) generation and clot (zeige TXNDC17 ELISA Kits) lysis assays on cells expressing thrombomodulin (zeige THBD ELISA Kits) and EPCR. Deficiency in EPCR has procoagulant effects that lead to a delay in clot (zeige TXNDC17 ELISA Kits) lysis.
Observations that binding of P. falciparum erythrocyte membrane protein 1 to EPCR results in an acquired functional protein C (zeige PROC ELISA Kits) system deficiency support the new paradigm that EPCR plays a central role in the pathogenesis of severe malaria. [review]
data suggest that either the lack of the protective EPCR 4678C allele or the presence of EPCR 4600G allele may be associated with earlier development of thrombosis.
These data suggest that 6936A/G polymorphism is a risk factor for deep venous thrombosis and is associated with elevated plasma levels of soluble EPCR, while 4678G/C polymorphism plays a role in protection against deep venous thrombosis.
PROCR thus does not globally inhibit Th17 responses but could be targeted to selectively inhibit proinflammatory Th17 cells.
Thrombin (zeige F2 ELISA Kits)-PAR1 (zeige F2R ELISA Kits) signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC (zeige FUT1 ELISA Kits)) mobilization. aPC (zeige APC ELISA Kits)-EPCR-PAR1 (zeige F2R ELISA Kits) signaling promotes HSC (zeige FUT1 ELISA Kits) retention in bone marrow.
impaired EPCR/protein C (zeige PROC ELISA Kits)-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
sPLA2 (zeige PLA2G2A ELISA Kits)-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C (zeige PROC ELISA Kits) activation.
HSCs appear to maintain expression of CD201 after hematopoietic injury when Kit expression is downregulated.
The protein C (zeige PROC ELISA Kits) receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS (zeige TLR4 ELISA Kits))-regulated gene expression.
Data indicate that endothelial protein C receptor (EPCR) binding enhances FVIIa hemostatic activity in vivo.
protein C (zeige PROC ELISA Kits) receptor (Procr), a novel Wnt (zeige WNT2 ELISA Kits) target in the mammary gland, marks a unique population of multipotent mouse mammary stem cells
FVIIa binding to EPCR leads to a barrier protective effect in vivo
Piperlonguminine might have potential as an anti-sEPCR shedding reagent against sepsis-mediated EPCR shedding.
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
protein C receptor, endothelial (EPCR)
, APC receptor
, CD201 antigen
, activated protein C receptor
, cell cycle, centrosome-associated protein
, endothelial protein C receptor
, endothelial cell protein C receptor
, CD antigen CD201
, centrosomal protein CCD41
, endothelial cell protein C/activated protein C