Protein C (Inactivator of Coagulation Factors Va and VIIIa) Proteine (PROC)

PROC encodes a vitamin K-dependent plasma glycoprotein. Zusätzlich bieten wir Ihnen PROC Antikörper (33) und PROC Kits (22) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PROC 25268 P31394
PROC 19123 P33587
PROC 5624 P04070
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Showing 10 out of 21 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Human His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
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HOST_Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
550,00 €
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HOST_Human Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
285,71 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ziege His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.240,16 €
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Hefe Pferd His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.240,16 €
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Hefe Cat His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.240,16 €
Details

PROC Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Rat (Rattus)

Mouse (Murine) ,

Human , , , ,
,

Am meisten referenzierte PROC Proteine

  1. Human PROC Protein expressed in Human Cells - ABIN2002308 : Hosac: Drotrecogin alfa (activated): the first FDA-approved treatment for severe sepsis. in Proceedings (Baylor University. Medical Center) 2005 (PubMed)

Weitere Proteine zu Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) Interaktionspartnern

Mouse (Murine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) Interaktionspartner

  1. loss of the convertase furin (zeige FURIN Proteine) or PC5 (zeige PCSK5 Proteine)/6 in hepatocytes results in a approximately 30% decrease in APC (zeige APC Proteine) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (zeige F2 Proteine) activation.

  2. APC (zeige APC Proteine) modifies pulmonary fibrosis by limiting thrombin (zeige F2 Proteine)-dependent macrophage recruitment.

  3. Small interfering RNA-mediated silencing of protein C in apolipoprotein E (zeige APOE Proteine)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.

  4. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (zeige APC Proteine)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (zeige APC Proteine) in the context of endotoxemia and infection

  5. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.

  6. impaired EPCR (zeige PROCR Proteine)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  7. SOD prevents thrombomodulin (zeige THBD Proteine) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.

  8. sPLA2 (zeige PLA2G2A Proteine)-V plays a thrombogenic role by impairing the ability of EPCR (zeige PROCR Proteine) to promote protein C activation.

  9. Data identify anticoagulant activated protein C as a "metaplastic molecule", capable of shifting the threshold of LTP (zeige SCP2 Proteine) towards further potentiation

  10. Histones regulate activated protein C formation in a manner similar to PF4 (zeige PF4 Proteine) and suggest heparinoids may be benificial in sepsis.

Human Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) Interaktionspartner

  1. A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency

  2. loss of the convertase furin (zeige FURIN Proteine) or PC5 (zeige PCSK5 Proteine)/6 in hepatocytes results in a approximately 30% decrease in APC (zeige APC Proteine) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (zeige F2 Proteine) activation.

  3. Both probands had hereditary protein C deficiencies, for which their parents were all carriers.

  4. Variants influencing circulating protein C levels in the CELSR2 (zeige CELSR2 Proteine)-PSRC1 (zeige PSRC1 Proteine)-SORT1 (zeige SORT1 Proteine) region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.

  5. These findings suggest that the anti-inflammatory function of APC (zeige APC Proteine) at therapeutic concentrations may include the inhibition of NETosis in an EPCR (zeige PROCR Proteine)-, PAR3 (zeige F2RL2 Proteine)-, and Mac-1 (zeige ITGAM Proteine)-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC (zeige APC Proteine) in disease states including sepsis.

  6. Collectively, these data depict a pivotal role for AMPK (zeige PRKAA1 Proteine) signaling in inhibiting ER stress responses via the activation of APC (zeige APC Proteine) during MGO-induced cardiomyocyte apoptosis. Thus, APC (zeige APC Proteine) may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy.

  7. An activation-resistant homozygous protein C R229W mutation was linked to perinatal intracranial bleeding and delayed onset of thrombosis.

  8. Structural and functional studies of novel heterozygous mutations in the PROC gene confirmed that the mutations were pathogenetic in two Chinese families with types I and II protein C deficiency.

  9. Study detected a statistically significant positive correlation between expanded disability status scale scores and thrombomodulin (zeige THBD Proteine) levels (p<0.01) and a 10% positive correlation between expanded disability status scale scores and APC (zeige APC Proteine) levels in multiple sclerosis patients

  10. Low protein C expression is associated with diabetes mellitus.

Cow (Bovine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) Interaktionspartner

  1. Activated protein c is a ghrelin (zeige GHRL Proteine) endopeptidase.

  2. Activated protein C(APC (zeige APC Proteine)) combined with protein S(PS) had significant antithrombotic effect. APC (zeige APC Proteine) combined with PS prolonged clotting time. Dependence on APC (zeige APC Proteine)-cofactor activity of PS for expression of anticoagulant activity by APC (zeige APC Proteine).

PROC Protein Überblick

Protein Überblick

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Genbezeichner und Symbole assoziert mit PROC

  • protein C (inactivator of coagulation factors Va and VIIIa), a (proca)
  • protein C (inactivator of coagulation factors Va and VIIIa) (PROC)
  • protein C (inactivator of coagulation factors Va and VIIIa) (proc)
  • protein C (inactivator of coagulation factors Va and VIIIa) (LOC100231143)
  • vitamin K-dependent protein C (CpipJ_CPIJ000393)
  • vitamin K-dependent protein C (CpipJ_CPIJ002754)
  • vitamin K-dependent protein C (CpipJ_CPIJ003717)
  • vitamin K-dependent protein C (CpipJ_CPIJ003718)
  • vitamin K-dependent protein C (CpipJ_CPIJ014440)
  • vitamin K-dependent protein C (CpipJ_CPIJ018032)
  • vitamin K-dependent protein C (CpipJ_CPIJ018737)
  • protein C (Proc)
  • APC Protein
  • MGC64425 Protein
  • PC Protein
  • PROC Protein
  • PROC1 Protein
  • si:ch1073-188c16.3 Protein
  • THPH3 Protein
  • THPH4 Protein
  • zgc:63987 Protein

Bezeichner auf Proteinebene für PROC

protein C , procl , anticoagulant protein C , vitamin K-dependent protein C , protein C (inactivator of coagulation factors Va and VIIIa) , vitamin K-dependent protein C-like , autoprothrombin IIA , blood coagulation factor XIV , inactivator of coagulation factors Va, VIII , catalytic region , protein C (precursor of vitamin K-dependent serine protease)

GENE ID SPEZIES
393327 Danio rerio
395085 Gallus gallus
459593 Pan troglodytes
100302329 Ovis aries
380116 Xenopus laevis
548476 Xenopus (Silurana) tropicalis
100231143 Taeniopygia guttata
100448857 Pongo abelii
6031231 Culex quinquefasciatus
6033948 Culex quinquefasciatus
6035053 Culex quinquefasciatus
6035054 Culex quinquefasciatus
6047546 Culex quinquefasciatus
6052150 Culex quinquefasciatus
6052641 Culex quinquefasciatus
25268 Rattus norvegicus
19123 Mus musculus
5624 Homo sapiens
281428 Bos taurus
101096161 Felis catus
476104 Canis lupus familiaris
100051306 Equus caballus
396954 Sus scrofa
100009223 Oryctolagus cuniculus
699077 Macaca mulatta
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