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PROC encodes a vitamin K-dependent plasma glycoprotein. Zusätzlich bieten wir Ihnen PROC Antikörper (34) und PROC Kits (22) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 21 products:
insulin (zeige INS Proteine) and aPC (zeige APC Proteine) converge on a common spliced-X-box binding protein-1 (zeige XBP1 Proteine) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
loss of the convertase furin (zeige FURIN Proteine) or PC5 (zeige PCSK5 Proteine)/6 in hepatocytes results in a approximately 30% decrease in APC (zeige APC Proteine) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (zeige F2 Proteine) activation.
APC (zeige APC Proteine) modifies pulmonary fibrosis by limiting thrombin (zeige F2 Proteine)-dependent macrophage recruitment.
Small interfering RNA-mediated silencing of protein C in apolipoprotein E (zeige APOE Proteine)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (zeige APC Proteine)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (zeige APC Proteine) in the context of endotoxemia and infection
activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.
impaired EPCR (zeige PROCR Proteine)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
SOD prevents thrombomodulin (zeige THBD Proteine) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.
sPLA2 (zeige PLA2G2A Proteine)-V plays a thrombogenic role by impairing the ability of EPCR (zeige PROCR Proteine) to promote protein C activation.
Data identify anticoagulant activated protein C as a "metaplastic molecule", capable of shifting the threshold of LTP (zeige SCP2 Proteine) towards further potentiation
EPCR (zeige PROCR Proteine) occupancy recruits G-protein coupled receptor kinase 5 (zeige GRK5 Proteine), thereby inducing beta-arrestin-2 (zeige ARRB2 Proteine) biased PAR1 (zeige MARK2 Proteine) signaling by both APC (zeige APC Proteine) and thrombin (zeige F2 Proteine). In
A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency
Both probands had hereditary protein C deficiencies, for which their parents were all carriers.
Variants influencing circulating protein C levels in the CELSR2 (zeige CELSR2 Proteine)-PSRC1 (zeige PSRC1 Proteine)-SORT1 (zeige SORT1 Proteine) region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.
These findings suggest that the anti-inflammatory function of APC (zeige APC Proteine) at therapeutic concentrations may include the inhibition of NETosis in an EPCR (zeige PROCR Proteine)-, PAR3 (zeige F2RL2 Proteine)-, and Mac-1 (zeige ITGAM Proteine)-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC (zeige APC Proteine) in disease states including sepsis.
Collectively, these data depict a pivotal role for AMPK (zeige PRKAA1 Proteine) signaling in inhibiting ER stress responses via the activation of APC (zeige APC Proteine) during MGO-induced cardiomyocyte apoptosis. Thus, APC (zeige APC Proteine) may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy.
An activation-resistant homozygous protein C R229W mutation was linked to perinatal intracranial bleeding and delayed onset of thrombosis.
Structural and functional studies of novel heterozygous mutations in the PROC gene confirmed that the mutations were pathogenetic in two Chinese families with types I and II protein C deficiency.
Study detected a statistically significant positive correlation between expanded disability status scale scores and thrombomodulin (zeige THBD Proteine) levels (p<0.01) and a 10% positive correlation between expanded disability status scale scores and APC (zeige APC Proteine) levels in multiple sclerosis patients
Activated protein c is a ghrelin (zeige GHRL Proteine) endopeptidase.
Activated protein C(APC (zeige APC Proteine)) combined with protein S(PS) had significant antithrombotic effect. APC (zeige APC Proteine) combined with PS prolonged clotting time. Dependence on APC (zeige APC Proteine)-cofactor activity of PS for expression of anticoagulant activity by APC (zeige APC Proteine).
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
, anticoagulant protein C
, vitamin K-dependent protein C
, protein C (inactivator of coagulation factors Va and VIIIa)
, vitamin K-dependent protein C-like
, autoprothrombin IIA
, blood coagulation factor XIV
, inactivator of coagulation factors Va, VIII
, catalytic region
, protein C (precursor of vitamin K-dependent serine protease)