anti-Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Antikörper

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Zusätzlich bieten wir Ihnen PCSK9 Kits (77) und PCSK9 Proteine (64) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top anti-PCSK9 Antikörper auf antikoerper-online.de

Showing 10 out of 160 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22408PU-N (1 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22408PU-N (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of PCSK9 Antibody (N-term) in Jurkat cell line lysates (35ug/lane). PCSK9 (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of PCSK9 Antibody (N-term) (ABIN652320) in Jurkat cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (N-term) (ABIN652320) IHC analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of PCSK9 antibody (C-term) (ABIN391505) in Hela cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (C-term) (ABIN391505) IHC analysis in formalin fixed and paraffin embedded human Colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Ziege Unkonjugiert EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22407PU-N (0.5 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22407PU-N(1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Ziege Unkonjugiert IHC, ELISA, WB ABIN185371 staining (0.2 µg/mL) of McA cell lysates: untransfected (1), transfected with wild type human pcsk9 (2), transfected with S127R human pcsk9 (3). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. ABIN185371 (0.3 µg/mL) staining of Human Adipose lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$326.89
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti-NARC1 Polyclonal Antibody, Unconjugated (ABIN761831) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$307.45
Details
Human Ziege Unkonjugiert ChIP, IHC (p), IHC, ELISA, WB Western Blot: PCSK9 Antibody [ABIN268772] - Analysis of PCSK9 in McA cell lysates: untransfected (1), transfected with wild type human PCSK9 (2), transfected with S127R human PCSK9 (3) using ABIN268772 (0.2ug/ml). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. Western Blot: PCSK9 Antibody [ABIN268772] - (0.3ug/ml) staining of Human Adipose lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$447.56
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-PCSK9 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$200.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$325.00
Details

PCSK9 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-PCSK9 Antikörper

  1. Human Polyclonal PCSK9 Primary Antibody für ChIP, IHC (p) - ABIN268772 : Cohen, Pertsemlidis, Kotowski, Graham, Garcia, Hobbs: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. in Nature genetics 2005 (PubMed)
    Show all 10 Pubmed References

  2. Human Polyclonal PCSK9 Primary Antibody für ELISA, WB - ABIN4347756 : Kwon, Lagace, McNutt, Horton, Deisenhofer: Molecular basis for LDL receptor recognition by PCSK9. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

  3. Human Polyclonal PCSK9 Primary Antibody für IF (p), IHC (p) - ABIN761831 : Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016 (PubMed)

  4. Human Polyclonal PCSK9 Primary Antibody für ELISA, IP - ABIN4347755 : Lalanne, Lambert, Amar, Chétiveaux, Zaïr, Jarnoux, Ouguerram, Friburg, Seidah, Brewer, Krempf, Costet: Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. in Journal of lipid research 2005 (PubMed)

Weitere Antikörper gegen PCSK9 Interaktionspartner

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartner

  1. LY3015014 is a humanized immunoglobulin G4 (IgG4) monoclonal antibody that binds to the catalytic domain of PCSK9.

  2. Increased PCSK9 levels are associated with higher platelet reactivity and predictive of ischemic events in acute coronary syndrome.

  3. Identify LDLR (zeige LDLR Antikörper), APOB (zeige APOB Antikörper) and PCSK9 novel mutations causing familial hypercholesterolemia in the central south region of China.

  4. Both circulating PCSK9 and SORT1 (zeige SORT1 Antikörper) levels are elevated in coronary artery disease patients.

  5. Rare variants of APOB (zeige APOB Antikörper) or PCSK9 were identified in nine of the 22 study patients with extremely low LDL-C levels

  6. PCSK9 plays a direct role on Abca1 (zeige ABCA1 Antikörper)-mediated cholesterol efflux through a downregulation of Abca1 (zeige ABCA1 Antikörper) gene and Abca1 (zeige ABCA1 Antikörper) protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.

  7. kidney function per se does not impact significantly PCSK9 metabolism

  8. Sirolimus therapy in heart transplant patients is associated with elevation in PCSK9 levels which is not associated with sirolimus-induced hypercholesterolemia.

  9. PCSK9 inhibits lipoprotein(a) clearance through the LDLR (zeige LDLR Antikörper).

  10. PCSK9 variants reduced fasting LDL-C as well as fasting triglycerides.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartner

  1. PCSK9 inhibits lipoprotein(a) clearance through the LDLR (zeige LDLR Antikörper).

  2. Use Crispr-Cas (zeige CTNND1 Antikörper) system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.

  3. Studied the combination model of a single AAV-PCSK9 injection, high-fat diet, and partial carotid ligation which induces robust atherosclerosis in the flow-disturbed carotid artery within 3 weeks in C57 mice, and results suggest this is a quick and convenient model to study atherosclerosis and mechanisms using any knockout or transgenic mice without having to generate double knockouts.

  4. These observations suggest positive feedback interplay between SMC (zeige DYM Antikörper)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  5. AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE (zeige APOE Antikörper)(-/-) mice.

  6. Adeno (zeige ADORA2A Antikörper)-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.

  7. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2 (zeige CA2 Antikörper)+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR (zeige LDLR Antikörper) degradation and promoting LDLR (zeige LDLR Antikörper)-dependent hepatic cholesterol uptake.

  8. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor (zeige LDLR Antikörper) Degradation.

  9. PCSK9 increases hepatic lipid and lipoprotein production via apoE (zeige APOE Antikörper)- and LDLR (zeige LDLR Antikörper)-dependent mechanisms

  10. Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.

PCSK9 Antigen-Profil

Protein Überblick

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Genbezeichner und Symbole assoziert mit PCSK9

  • proprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L) Antikörper
  • proprotein convertase subtilisin/kexin type 9 (pcsk9) Antikörper
  • proprotein convertase subtilisin/kexin type 9 (PCSK9) Antikörper
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9) Antikörper
  • AI415265 Antikörper
  • AI747682 Antikörper
  • FH3 Antikörper
  • HCHOLA3 Antikörper
  • LDLCQ1 Antikörper
  • NARC-1 Antikörper
  • Narc1 Antikörper
  • PC9 Antikörper

Bezeichner auf Proteinebene für PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPEZIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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