Prokineticin 2 Proteine (PROK2)

PROK2 encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. Zusätzlich bieten wir Ihnen Prokineticin 2 Antikörper (60) und Prokineticin 2 Kits (47) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PROK2 192206 Q8R413
PROK2 50501 Q9QXU7
PROK2 60675 Q9HC23
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Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
609,52 €
Details
HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 6 bis 8 Tage
849,73 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.014,92 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.074,29 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   20 μg Anmelden zum Anzeigen 10 bis 13 Tage
322,10 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   20 μg Anmelden zum Anzeigen 8 bis 11 Tage
218,90 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 11 bis 15 Tage
563,81 €
Details

PROK2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Rat (Rattus) ,

Mouse (Murine) ,

Human , ,
,

Weitere Proteine zu Prokineticin 2 (PROK2) Interaktionspartnern

Rhesus Monkey Prokineticin 2 (PROK2) Interaktionspartner

  1. expression of PKR2 (zeige PROKR2 Proteine) in the raphe nuclei of both macaque and mouse brain signifies a possible role of dorsal raphe nucleus

Zebrafish Prokineticin 2 (PROK2) Interaktionspartner

  1. Both overexpression and mutation of the neuropeptide prokineticin 2 (Prok2) affect sleep and wake behaviors in a light-dependent but circadian-independent manner.

  2. In adult zebrafish, PROK2 may play a role in both constitutive and injury-induced neurogenesis during telencephalon regeneration.

Cow (Bovine) Prokineticin 2 (PROK2) Interaktionspartner

  1. EG-VEGF/PK1 and Bv8/PK2 thus represent new regulatory peptides acting as autocrine mitogens for endocrine cells

Mouse (Murine) Prokineticin 2 (PROK2) Interaktionspartner

  1. In mouse models, PK2 over-expression aggravated psoriasis while its knock-down inhibited pathologi (zeige IL1A Proteine)cal development. The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target.

  2. PROK2 plays a role in cerebral amyloidosis and that PROK2 antagonists may represent a new approach for ameliorating the defining pathology of AD.

  3. Data show that the prokineticins and their receptors PROK2, PKR1 (zeige PROKR1 Proteine) and PKR2 (zeige PROKR2 Proteine) contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.

  4. These findings suggest that PROK2 plays a crucial role in neuropathic pain and might represent a novel target of treatment for this disease.

  5. Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals

  6. PK2 plays an important role in energy intake and expenditure.

  7. Induction of Bv8 expression by granulocyte colony-stimulating factor (zeige CSF3 Proteine) in CD11b (zeige ITGAM Proteine)+Gr1 (zeige GSR Proteine)+ cells: key role of Stat3 (zeige STAT3 Proteine) signaling.

  8. Data suggest that elevated prokineticin 2 levels, as a consequence of gastrointestinal tract inflammation, induce visceral pain via prokineticin receptors.

  9. Intracerebroventricular administration of PK2 affects regulation of food intake.

  10. Bv8 and EG-VEGF (zeige Prok1 Proteine), along with other factors such as VEGF-A (zeige VEGFA Proteine), may maintain the integrity and also regulate proliferation of the blood vessels in the testis

Human Prokineticin 2 (PROK2) Interaktionspartner

  1. The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 (zeige IL1A Proteine) vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target.

  2. Prokineticin-2 is correlated with various cardiometabolic risk factors.

  3. Data suggest that prokineticins (PROK1 (zeige Prok1 Proteine) and PROK2) and prokineticin receptors (PROKR1 (zeige PROKR1 Proteine) and PROKR2 (zeige PROKR2 Proteine)) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW]

  4. Suggest PROK2 as an angiogenic growth factor in colorectal cancer.

  5. study found a novel mutation in PROK2 in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR (zeige GNRHR Proteine) gene had been previously described, suggesting the possibility of a digenic inheritance

  6. PROK2 significantly increased in human fetal ovary across gestation.

  7. EG-VEGF (zeige Prok1 Proteine), BV8, and PROKR2 (zeige PROKR2 Proteine) gene expression is approximately five, four, and two times higher in cystic fibrosis (zeige S100A8 Proteine) lungs compared with controls.

  8. No abnormalities were found in the patient group for the PROKR2 (zeige PROKR2 Proteine) and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes

  9. PROK2 signaling in humans is not required for central circadian pacemaker function.

  10. A novel role of BV8 in promoting oncogenesis intrinsic to malignant cells of myeloid origin.

Prokineticin 2 (PROK2) Protein Überblick

Protein Überblick

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit Prokineticin 2 Proteine (PROK2)

  • prokineticin 2 (PROK2)
  • prokineticin 2 (prok2)
  • prokineticin 2 (Prok2)
  • BV8 Protein
  • HH4 Protein
  • KAL4 Protein
  • MIT1 Protein
  • PK2 Protein
  • Prok1 Protein
  • PROK2 Protein

Bezeichner auf Proteinebene für Prokineticin 2 Proteine (PROK2)

prokineticin 2 , prokineticin-2 , PK2 , homolog of mouse Bv8 (Bombina variegata 8 kDa) , homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2 , prokineticin 2 beta , Bombina variegata 8 kD protein , Bombina variegata 8kDa protein , Bv 8 homolog (Bombina variegata) , prokineticin 1 , protein Bv8 homolog

GENE ID SPEZIES
694450 Macaca mulatta
736902 Pan troglodytes
100006398 Danio rerio
100037158 Xenopus laevis
387602 Bos taurus
192206 Rattus norvegicus
50501 Mus musculus
60675 Homo sapiens
100728998 Cavia porcellus
610873 Canis lupus familiaris
771674 Gallus gallus
101104864 Ovis aries
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