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PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Zusätzlich bieten wir Ihnen PDCD4 Antikörper (251) und PDCD4 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
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evaluate the relative expression levels of miR (zeige MLXIP Proteine)-196a2 and three of its selected apoptosis-related targets; ANXA1 (zeige ANXA1 Proteine), DFFA (zeige DFFA Proteine) and PDCD4 in a sample of GI cancer patients
In colorectal cancer tissues, the Sin1 (zeige MAPKAP1 Proteine) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (zeige MAPKAP1 Proteine) protein level but not mRNA level in colorectal cancer.
miRNA-96 is significantly overexpressed in glioma tissues. Moreover, miRNA-96 plays a critical role in apoptosis by inhibiting the expression of PDCD4 in glioma.
Supporting the clinical relevance of our results, we found an inverse correlation between ErbB-2 (zeige ERBB2 Proteine)/Stat3 (zeige STAT3 Proteine) nuclear co-expression and PDCD4 expression in ErbB-2 (zeige ERBB2 Proteine)-positive primary invasive breast cancer
this study highlights an oncomiR role for miR (zeige MLXIP Proteine)-181b in regulating PDCD4 in colorectal cancer and suggests that miR (zeige MLXIP Proteine)-181b may be a novel molecular therapeutic target for colorectal cancer.
Higher PDCD4 expression plays a role in polycystic ovary syndrome by affecting obesity, insulin (zeige INS Proteine) resistance, lipid metabolism disorders, and granulosa cell apoptosis.
results revealed that microRNA 200a inhibits erythroid differentiation by targeting PDCD4 and THRB (zeige THRB Proteine)
The expression of miR (zeige MLXIP Proteine)-21 and PDCD4 at messenger RNA level was evaluated by quantitative real-time polymerase chain reaction, while the protein level of PDCD4 was determined by Western blotting. Authors found that locked nucleic acid-anti-miR (zeige MLXIP Proteine)-21 transfection was associated with a significant reduction in metastatic properties as assessed by the in ovo model.
Data indicate that programmed cell death 4 (PDCD4) was identified to be a target of ubiquitin-specific protease 4 (USP4 (zeige USP4 Proteine)), which plays a role as a tumor suppressor.
PDCD4 down-regulation is involved in the progression of several types of solid tumor.
-induced expression of PDCD4 is associated with increased beta cell death.
miR (zeige MLXIP Proteine)-155 not only directly inhibited SOCS1 (zeige SOCS1 Proteine) expression, but also increased the expression of p-STAT (zeige STAT1 Proteine) and PDCD4, as well as the production of proinflammation mediators IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine) in atherogenesis
our data suggest that Pdcd4 as a crucial regulator in SGs (zeige SKI Proteine) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.
Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (zeige IL10 Proteine).
PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (zeige IL6 Proteine)/STAT3 (zeige STAT3 Proteine) Pathway.
Study found that miR-16 (zeige GDE1 Proteine) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (zeige NFKB1 Proteine) and MAPK (zeige MAPK1 Proteine) pathways.
Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.
PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.
In conclusion, miR (zeige MLXIP Proteine)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.
miR (zeige MYLIP Proteine)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (zeige NFKB1 Proteine)/ TNF-alpha (zeige TNF Proteine) pathway in cardiomyocytes.
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
neoplastic transformation inhibitor protein
, nuclear antigen H731
, programmed cell death protein 4
, protein 197/15a
, protein MA-3
, topoisomerase-inhibitor suppressed protein
, death up-regulated gene protein
, programmed cell death 4
, protein I11/6
, programmed cell death 4 (neoplastic transformation inhibitor)
, programmed cell death protein 4-like