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PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Zusätzlich bieten wir Ihnen PDCD4 Kits (18) und PDCD4 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 250 products:
Human Monoclonal PDCD4 Primary Antibody für IHC, ELISA - ABIN1043755
Jansen, Camalier, Colburn: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. in Cancer research 2005
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Human Polyclonal PDCD4 Primary Antibody für IF (p), IHC (p) - ABIN731993
Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014
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Human Polyclonal PDCD4 Primary Antibody für IP, IHC - ABIN1043890
Huang, Wu, Loeb, Hsu, Heidersbach, Brincat, Horiuchi, Lebbink, Mo, Goga, McManus: Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. in The Journal of biological chemistry 2009
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Human Monoclonal PDCD4 Primary Antibody für ELISA, WB - ABIN316114
Abraham, Jackson, Gundara, Zhao, Gill, Delbridge, Robinson, Sidhu: MicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis, and potential therapeutic targets. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Human Polyclonal PDCD4 Primary Antibody für IF, ELISA - ABIN1532754
Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: The DNA sequence and comparative analysis of human chromosome 10. ... in Nature 2004
Human Polyclonal PDCD4 Primary Antibody für IHC (p), WB - ABIN657922
Hayashi, Aishima, Miyasaka, Nakata, Morimatsu, Oda, Nagai, Oda, Tanaka, Tsuneyoshi: Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation. in Human pathology 2010
Human Monoclonal PDCD4 Primary Antibody für EIA, IHC (p) - ABIN317548
Palamarchuk, Efanov, Maximov, Aqeilan, Croce, Pekarsky: Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. in Cancer research 2005
Cow (Bovine) Polyclonal PDCD4 Primary Antibody für WB - ABIN2774608
Yang, Matthews, Clair, Wang, Baker, Li, Tan, Colburn: Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. in Molecular and cellular biology 2006
miR (zeige MLXIP Antikörper)-155 not only directly inhibited SOCS1 (zeige SOCS1 Antikörper) expression, but also increased the expression of p-STAT (zeige STAT1 Antikörper) and PDCD4, as well as the production of proinflammation mediators IL-6 (zeige IL6 Antikörper) and TNF-alpha (zeige TNF Antikörper) in atherogenesis
our data suggest that Pdcd4 as a crucial regulator in SGs (zeige SKI Antikörper) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.
Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (zeige IL10 Antikörper).
PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (zeige IL6 Antikörper)/STAT3 (zeige STAT3 Antikörper) Pathway.
Study found that miR-16 (zeige GDE1 Antikörper) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (zeige NFKB1 Antikörper) and MAPK (zeige MAPK1 Antikörper) pathways.
Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.
PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.
In conclusion, miR (zeige MLXIP Antikörper)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.
atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells
we demonstrate that miR (zeige MLXIP Antikörper)-21 regulates T-cell acute lymphoblastic leukemia cell survival via repression of the tumor suppressor Pdcd4.
Supporting the clinical relevance of our results, we found an inverse correlation between ErbB-2 (zeige ERBB2 Antikörper)/Stat3 (zeige STAT3 Antikörper) nuclear co-expression and PDCD4 expression in ErbB-2 (zeige ERBB2 Antikörper)-positive primary invasive breast cancer
this study highlights an oncomiR role for miR (zeige MLXIP Antikörper)-181b in regulating PDCD4 in colorectal cancer and suggests that miR (zeige MLXIP Antikörper)-181b may be a novel molecular therapeutic target for colorectal cancer.
Higher PDCD4 expression plays a role in polycystic ovary syndrome by affecting obesity, insulin (zeige INS Antikörper) resistance, lipid metabolism disorders, and granulosa cell apoptosis.
results revealed that microRNA 200a inhibits erythroid differentiation by targeting PDCD4 and THRB (zeige THRB Antikörper)
The expression of miR (zeige MLXIP Antikörper)-21 and PDCD4 at messenger RNA level was evaluated by quantitative real-time polymerase chain reaction, while the protein level of PDCD4 was determined by Western blotting. Authors found that locked nucleic acid-anti-miR (zeige MLXIP Antikörper)-21 transfection was associated with a significant reduction in metastatic properties as assessed by the in ovo model.
Data indicate that programmed cell death 4 (PDCD4) was identified to be a target of ubiquitin-specific protease 4 (USP4 (zeige USP4 Antikörper)), which plays a role as a tumor suppressor.
PDCD4 down-regulation is involved in the progression of several types of solid tumor.
Results show that exosome-shuttling miR (zeige MLXIP Antikörper)-21 represses PDCD4 protein expression by binding to 3'-UTR (zeige UTS2R Antikörper) in esophageal cancer cells.
miR (zeige MLXIP Antikörper)-21, acting on PDCD4, which interacts with Twist1 (zeige TWIST1 Antikörper) and represses the expression of Twist1 (zeige TWIST1 Antikörper), contributes to the EMT (zeige ITK Antikörper) induced by arsenite in transformed bronchial epithelial cells.
Data show that microRNA miR (zeige MLXIP Antikörper)-93 directly binds to the 3' untranslated regions (3'-UTR (zeige UTS2R Antikörper)) of the programmed cell death 4 (PDCD4) mRNA transcript and inhibits PDCD4 translation in gastric cancer cells
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (zeige NFKB1 Antikörper)/ TNF-alpha (zeige TNF Antikörper) pathway in cardiomyocytes.
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
neoplastic transformation inhibitor protein
, nuclear antigen H731
, programmed cell death protein 4
, protein 197/15a
, protein MA-3
, topoisomerase-inhibitor suppressed protein
, death up-regulated gene protein
, programmed cell death 4
, protein I11/6
, programmed cell death 4 (neoplastic transformation inhibitor)
, programmed cell death protein 4-like