anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Antikörper

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Zusätzlich bieten wir Ihnen Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
KCNA2 3737 P16389
KCNA2 16490 P63141
KCNA2 25468 P63142
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Top anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Antikörper auf antikoerper-online.de

Showing 10 out of 69 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Maus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Rind (Kuh) Kaninchen Unkonjugiert ICC, IF, IP, WB 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$381.94
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue reacted with AP52299PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of KCNA2 Antibody (C-term) in CEM cell line lysates (35ug/lane). This demonstrates the KCNA2 antibody detected the KCNA2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Rind (Kuh) Kaninchen Unkonjugiert BP, IP, Neut, WB 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$408.19
Details
Human Kaninchen Unkonjugiert IHC (p), WB KCNA2 Antibody (C-term) (ABIN658605) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the KCNA2 antibody detected the KCNA2 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB   0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IF, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$323.13
Details
Ratte Kaninchen Unkonjugiert IHC, WB   100 μL Anmelden zum Anzeigen 7 bis 8 Tage
$454.67
Details
Rind (Kuh) Kaninchen Unkonjugiert IP, Neut, WB   100 μL Anmelden zum Anzeigen 6 bis 7 Tage
$506.80
Details
Rind (Kuh) Kaninchen Biotin ICC, IF, WB   0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$500.06
Details

KCNA2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Antikörper

  1. Mammalian Monoclonal KCNA2 Primary Antibody für ISt, IHC - ABIN1304746 : Miyazaki, Oyama, Inoue, Aosaki, Abe, Kiyonari, Kino, Kurosawa, Shimizu, Ogiwara, Yamakawa, Koshimizu, Fujiyama, Kaneko, Shimizu, Nagatomo, Yamada, Shimogori, Hattori, Miura, Nukina: Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum. in Nature communications 2014 (PubMed)
    Show all 104 Pubmed References

  2. Cow (Bovine) Polyclonal KCNA2 Primary Antibody für ICC, IF - ABIN449234 : Joseph, Thakali, Pathan, Kang, Rusch, Rhee: Postsynaptic density-95 scaffolding of Shaker-type K? channels in smooth muscle cells regulates the diameter of cerebral arteries. in The Journal of physiology 2011 (PubMed)
    Show all 2 Pubmed References

  3. Mammalian Monoclonal KCNA2 Primary Antibody für ISt, IHC - ABIN1304747 : Manning, Bundros, Trimmer: Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance. in PLoS ONE 2012 (PubMed)

  4. Cow (Bovine) Polyclonal KCNA2 Primary Antibody für BP, IP - ABIN452088 : Zhou, Ma, Huang: Specific antibodies to the external vestibule of voltage-gated potassium channels block current. in The Journal of general physiology 1998 (PubMed)

Weitere Antikörper gegen Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 Interaktionspartner

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Interaktionspartner

  1. study indicates well represented genotype-phenotype associations between three subgroups of patients with KCNA2 encephalopathy according to the electrophysiological features of the mutations.

  2. Pharmacogenetic and case-control study evaluated the role of the variants of KCNA1 (zeige KCNA1 Antikörper), KCNA2, and KCNV2 (zeige KCNV2 Antikörper) in the susceptibility and drug resistance of genetic generalized epilepsies and revealed no significant association between 8 variants of KCNA1 (zeige KCNA1 Antikörper), KCNA2, and KCNV2 (zeige KCNV2 Antikörper) genes and risk or drug resistance of genetic generalized epilepsies after a Bonferroni correction for multiple comparisons.

  3. In the asymptomatic mother, the mutated copy of the CDKL5 (zeige CDKL5 Antikörper) gene was inactivated in 90% of blood cells. We also identified a premature stop codon (p.Arg926*) in IQSEC2 (zeige IQSEC2 Antikörper) in a patient with a Rett-like phenotype. Finally, exome sequencing enabled us to characterize a heterozygous de novo missense (p.Val408Ala) in KCNA2 in a girl with infantile-onset seizures variant of Rett syndrome (RTT)

  4. Novel recurrent missense mutation within the Kv1.2 voltage sensor associated with variable phenotypes, including hereditary spastic paraplegia, ataxia, and intellectual disability.

  5. This study demonstrated that KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy.

  6. Use-dependent activation of Kv1.2 channels is mediated by an extrinsic regulator that binds preferentially to the channel closed state, with Thr252 being necessary but not sufficient for this interaction to alter channel function.

  7. This gene has not been previously described as a cause of disease in humans, but mutations of the orthologous gene in mice (Kcna2) are known to cause both ataxia and convulsions

  8. KCNA2 is a new gene involved in human neurodevelopmental disorders through two different mechanisms, predicting either hyperexcitability or electrical silencing of KV1.2-expressing neurons.

  9. the inhibition of two K(+) channel (zeige KCNC4 Antikörper) isoforms, Kv1.2 and KCa3.1 (zeige KCNN4 Antikörper), by two drug molecules, lidocaine and TRAM (zeige TRAM1 Antikörper)-34, is examined in atomic detail using molecular dynamics simulations.

  10. isoform betaII plays a central role in the PKC (zeige PRRT2 Antikörper)-dependent regulation of Kv1.5 (zeige KCNA5 Antikörper)/Kvbeta1.2 channels.

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Interaktionspartner

  1. Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 (zeige CA3 Antikörper) pyramidal cells

  2. analysis of fine-tuning of voltage sensitivity of the Kv1.2 potassium channel by interhelix loop dynamics

  3. This study showed that MK2 kinase is activated by TcdA and TcdB and regulates the expression of proinflammatory cytokines.

  4. Mk2 homozygous deletion in mice impedes the induction of experimental colitis by dextran sodium sulfate, confirming the notion that p38 (zeige CRK Antikörper)/Mk2 is involved in this inflammatory response.

  5. The dynamic Sig-1R (zeige SIGMAR1 Antikörper)-Kv1.2 complex represents a mechanism that shapes neuronal and behavioral response to cocaine.

  6. Overlapping patterns with differential expression and precise localization of Kv1.1 and Kv1.2 channels targeted to specialized subcellular compartments contribute to distinctive patterns of neuronal excitability --REVIEW

  7. the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated.

  8. These results suggest that independent of known mutations in Kcna1 (zeige KCNA1 Antikörper) encoding Kv1.1, Kcna2 mutations may be important molecular correlates underlying human cerebellar ataxic disease.

  9. Data show that PSD-95 (zeige DLG4 Antikörper) colocalizes precisely with Kv1 (zeige KCNA5 Antikörper) potassium channels and Caspr2 (zeige CNTNAP2 Antikörper) at juxtaparanodes, and that a macromolecular complex of Kv1 (zeige KCNA5 Antikörper) channels and PSD-95 (zeige DLG4 Antikörper) can be immunopurified from mammalian brain and spinal cord.

  10. Kcna2-null mice exhibited increased seizure susceptibility but, in contrast to Kcna1 (zeige KCNA1 Antikörper)-null mice, hypoexcitability and enlarged Kv1 (zeige KCNA5 Antikörper) currents in auditory neurons.

Xenopus laevis Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Interaktionspartner

  1. When mapped onto the X-ray structure of the K(v)1.2 channel the large number of permissive mutations support the notion of relatively independent domains, consistent with crystallographic studies

Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Antigen-Profil

Protein Überblick

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Genbezeichner und Symbole assoziert mit KCNA2

  • potassium voltage-gated channel subfamily A member 2 (KCNA2) Antikörper
  • potassium channel, voltage gated shaker related subfamily A, member 1 (kcna1) Antikörper
  • potassium voltage-gated channel, shaker-related subfamily, member 2 (Kcna2) Antikörper
  • potassium voltage-gated channel subfamily A member 2 (Kcna2) Antikörper
  • potassium voltage-gated channel subfamily A member 2 (LOC100537815) Antikörper
  • potassium channel, voltage gated shaker related subfamily A, member 2 S homeolog (kcna2.S) Antikörper
  • Akr6a4 Antikörper
  • BK2 Antikörper
  • ENSMUSG00000074335 Antikörper
  • Gm10672 Antikörper
  • HBK5 Antikörper
  • HK4 Antikörper
  • HUKIV Antikörper
  • k(v)1.2 Antikörper
  • Kca1-2 Antikörper
  • kcna2 Antikörper
  • kcna2-a Antikörper
  • kv1.2 Antikörper
  • Mk-2 Antikörper
  • MK2 Antikörper
  • NGK1 Antikörper
  • RBK2 Antikörper
  • XSha2 Antikörper

Bezeichner auf Proteinebene für KCNA2

potassium voltage-gated channel, shaker-related subfamily, member 2 , potassium voltage-gated channel subfamily A member 2-like , potassium voltage-gated channel subfamily A member 2 , voltage-gated potassium channel Kv1.2 , shaker subfamily potassium channel Kv1.2 alpha subunit , voltage-gated K(+) channel HuKIV , voltage-gated potassium channel HBK5 , voltage-gated potassium channel protein Kv1.2 , voltage-gated potassium channel subunit Kv1.2 , MK2 , Potassium (K+) channel protein alpha 2, voltage dependent , RAK , RBK2 , RCK5 , potassium voltage gated channel shaker related subfamily member 2 , Kv1.2' potassium channel , Voltage-gated potassium channel subunit Kv1.2 , potassium voltage-gated channel, shaker-related subfamily, member 2 a , CSMK1 , delayed rectifier K+ channel , voltage-dependent K channel , voltage-gated channel, shaker-related subfamily, member 2 , potassium channel (BGK5)

GENE ID SPEZIES
469413 Pan troglodytes
702126 Macaca mulatta
100076742 Ornithorhynchus anatinus
100145813 Xenopus (Silurana) tropicalis
100444529 Pongo abelii
100478109 Ailuropoda melanoleuca
100596531 Nomascus leucogenys
395117 Gallus gallus
3737 Homo sapiens
16490 Mus musculus
25468 Rattus norvegicus
100537815 Danio rerio
373840 Xenopus laevis
404022 Canis lupus familiaris
397292 Sus scrofa
539608 Bos taurus
Ausgewählte Anbieter für anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 2 (KCNA2) Antikörper
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