anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Antikörper

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. Zusätzlich bieten wir Ihnen Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
KCNQ2 3785 O43526
KCNQ2 170848 O88943
KCNQ2 16536 Q9Z351
Direkt bei antikoerper-online bestellen
  • +49 (0)241 95 163 153
  • +49 (0)241 95 163 155
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Antikörper auf antikoerper-online.de

Showing 10 out of 91 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-KCNQ2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-KCNQ2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5µg/ml using anti-KCNQ2 antibody (ARP35458_P050) 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-KCNQ2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>NCI-H226 cell lysate Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5µg/ml using anti-KCNQ2 antibody (ARP35457_P050) 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Hamster Maus Unkonjugiert AA, ICC, IF, IHC, IP, WB KCNQ2 (s26A 23), Human hippocampus. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
411,87 €
Details
Hamster Maus HRP AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
453,77 €
Details
Hamster Maus FITC AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
458,56 €
Details
Hamster Maus Alkaline Phosphatase (AP) AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
460,95 €
Details
Hamster Maus Biotin AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
463,34 €
Details
Hamster Maus PE AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
464,54 €
Details

KCNQ2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , , ,
,
,
, , , , , , , , , , , , , , , , , , ,
Rat (Rattus) , , ,
,
,
, , , , , , , , , , , , , , , , , , ,
Mouse (Murine) , , ,
,
,
, , , , , , , , , , , , , , , , , , ,

Am meisten referenzierte anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Antikörper

  1. Mammalian Monoclonal KCNQ2 Primary Antibody für ISt, IHC - ABIN1304776 : Miceli, Soldovieri, Ambrosino, De Maria, Migliore, Migliore, Taglialatela: Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)
    Show all 12 Pubmed References

  2. Cow (Bovine) Polyclonal KCNQ2 Primary Antibody für IHC, WB - ABIN2776304 : Tang, Li, Xia, Jiang, Pan, Shen, Long, Zhao, Cai: A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family. in Journal of the neurological sciences 2004 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Interaktionspartner

Horse (Equine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Interaktionspartner

  1. The KCNQ2 and KCNQ3 (zeige KCNQ3 Antikörper) genes are located on the terminal region of chromosomes 22 and 9, respectively. The KCNQ2 gene tree exhibited close clustering between horses and humans, relative to horses and mice.

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Interaktionspartner

  1. The direct effect of heat on KCNQ2 channels may be involved in excitability regulation of neurons, and the P-loop region is critical for temperature-dependent modulation of the expression and trafficking of KCNQ2 channels.

  2. Epileptic encephalopathy with burst suppression without brain malformations is associated with pathogenic variation in KCNQ2.

  3. Heterozygous KCNQ2 R201C and R201H gain-of-function variants present with profound neonatal encephalopathy in the absence of neonatal seizures.

  4. This study provide evidence for a new phenotypic and functional profile in KCNQ2-related epilepsy.

  5. In the present work, a pharmacophore-based 3D-QSAR model was generated for a series of N-pyridyl and pyrimidine benzamides possessing KCNQ2/Q3 opening activity. The pharmacophore model generated contains one hydrogen bond donor (D), one hydrophobic (H), and two aromatic rings (R). They are the crucial molecular write-up detailing predicted binding efficacy of high affinity and low affinity ligands for KCNQ2/Q3 opening a

  6. This study demonstrated that Mutations in the KCNQ2 gene encoding the voltage-gated potassium channel subunit Kv7.2 cause early onset epileptic encephalopathy .

  7. This work shows for the first time the association between KCNQ2 mutations and startle attacks in 38% of patients, which opens the possibility to define electroclinical phenotypes associated to KCNQ2 mutations. It also demonstrates that KCNQ2 mutations contribute to an important percentage of Spanish patients with epilepsy.

  8. USP36 (zeige USP36 Antikörper) actions extend beyond TrkA (zeige NTRK1 Antikörper) because the presence of USP36 (zeige USP36 Antikörper) interferes with Nedd4-2 (zeige NEDD4L Antikörper)-dependent Kv7.2/3 channel regulation.

  9. a structural mechanism for the gating of the Kv7.3 (zeige KCNQ3 Antikörper) PM and for the site of action of RTG as a Kv7.2/Kv7.3 (zeige KCNQ3 Antikörper) K(+) current activator.

  10. There is a variable clinical expression in infantile epilepsy patients with mosaicism for KCNQ2 mutations.

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Interaktionspartner

  1. The data of this study showed that, in Kcnq2 mutant slices, burst activity was modulated by GABAA (zeige GABRg1 Antikörper) receptor blockade.

  2. Kcnq2 ablation leads to increased neuronal excitability of neocortex layer 2/3 pyramidal neurons.

  3. USP36 (zeige USP36 Antikörper) actions extend beyond TrkA (zeige NTRK1 Antikörper) because the presence of USP36 (zeige USP36 Antikörper) interferes with Nedd4-2 (zeige NEDD4L Antikörper)-dependent Kv7.2/3 channel regulation.

  4. Mechanosensitivity of Skin Down-hair mechanoeceptors is increased in Kcnq3 (zeige KCNQ3 Antikörper)-/- and in Kcnq2+/-/Kcnq3 (zeige KCNQ3 Antikörper)-/- Mutant Mice.

  5. Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.

  6. Reduced M-current in the superior cervical ganglion neurons of Kcnq2 truncation mutation heterozygotic mice.

  7. Data show that a reduction in Kv7.2/3 channel activity is essential for tinnitus induction and for the tinnitus-specific hyperactivity.

  8. Retigabine is more effective on KCNQ3 (zeige KCNQ3 Antikörper) than KCNQ2, whereas ZnPy is more effective on KCNQ2 with no detectable effect on KCNQ3 (zeige KCNQ3 Antikörper).

  9. Results show that in the same protein complex in which PKA augments L currents, AKAP79 (zeige AKAP5 Antikörper)/150 directs calcineurin to activate NFAT (zeige NFATC1 Antikörper) and initiate a longer-term feedback loop that upregulates M-channel expression, countering increased neuronal excitability.

  10. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 (zeige KCNQ3 Antikörper) > KCNQ4 (zeige KCNQ4 Antikörper) > KCNQ5 (zeige KCNQ5 Antikörper) > KCNQ1 (zeige KCNQ1 Antikörper) > KCNQ2.

Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Antigen-Profil

Protein Überblick

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit KCNQ2

  • potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2) Antikörper
  • potassium voltage-gated channel, KQT-like subfamily, member 2 (Kcnq2) Antikörper
  • potassium voltage-gated channel, KQT-like subfamily, member 2 (kcnq2) Antikörper
  • potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2) Antikörper
  • BFNC Antikörper
  • BFNS1 Antikörper
  • EBN Antikörper
  • EBN1 Antikörper
  • EIEE7 Antikörper
  • ENB1 Antikörper
  • HNSPC Antikörper
  • KCNA11 Antikörper
  • KQT2 Antikörper
  • KV7.2 Antikörper
  • KVEBN1 Antikörper
  • Nmf134 Antikörper

Bezeichner auf Proteinebene für KCNQ2

KQT-like 2 , neuroblastoma-specific potassium channel protein , neuroblastoma-specific potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel subfamily KQT member 2 , voltage-gated potassium channel subunit Kv7.2 , potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel, subfamily Q, member 2

GENE ID SPEZIES
100146986 Equus caballus
3785 Homo sapiens
170848 Rattus norvegicus
100537363 Danio rerio
428151 Gallus gallus
505963 Bos taurus
16536 Mus musculus
612515 Canis lupus familiaris
Ausgewählte Anbieter für anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Antikörper
Haben Sie etwas anderes gesucht?