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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Zusätzlich bieten wir Ihnen KCNJ15 Antikörper (38) und viele weitere Produktgruppen zu diesem Protein an.
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KCNJ15 couples with polyamines in sensing weak electric fields.
RNA-seq evidence of biallelic expression of KCNJ15 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of KCNJ15 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (zeige WRB Proteine) differentially methylated region (DMR (zeige WDR20 Proteine)) in disomic controls or trisomy (Down syndrome) individuals.
KCNJ15 has a major role in histamine-stimulated gastric acid secretion.
We had performed a replication study using an independent larger Japanese population for the association of rs3746876 within KCNJ15, and observed a significant association of rs3746876 with type 2 diabetes, but this study failed to find original finding.
It was shown that downregulation of Kcnj15 leads to increased insulin (zeige INS Proteine) secretion in vitro and in vivo. The mechanism for regulating insulin (zeige INS Proteine) secretion inolved a calcium-sensiong receptor.
KCNJ15 is a previously unreported susceptibility gene for T2DM among Asians
The potential synergy and consequences of the overexpression of KIR4.2 and KIR3.2 (zeige KCNJ6 Proteine) in Down's syndrome brain development are discussed.
Calcium-sensing receptor (zeige CASR Proteine) interacts directly with Kir4.1 (zeige KCNJ10 Proteine) and Kir4.2 and can decrease their currents.
MUPP1 and Kir4.2 may participate in a protein complex in the nephron that could regulate transport of K(+) as well as other ions.
Data show that KCNJ15 inward rectifier potassium channel and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents are changed in Trisomic neuron.
in nonsecreting parietal cells, KCNJ15 is stored in vesicles distinct from the H(+)-K(+)-ATPase (zeige ATP4b Proteine)-enriched tubulovesicles. Furthermore, upon stimulation, KCNJ15 and H(+)-K(+)-ATPase (zeige ATP4b Proteine) both translocate to the apical membrane for active acid secretion.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene.
ATP-sensitive inward rectifier potassium channel 15
, inward rectifier K(+) channel Kir1.3
, inward rectifier K(+) channel Kir4.2
, inward rectifier K+ channel KIR4.2
, potassium channel, inwardly rectifying subfamily J member 15
, potassium inwardly-rectifying channel, subfamily J, member 15
, potassium inwardly-rectifying channel, subfamily J, member 1
, inward rectifier K+ channel Kir4.2
, potassium inwardly-rectifying channel J15
, Potassium channel, inwardly rectifying subfamily J member 15