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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Zusätzlich bieten wir Ihnen Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 88 products:
Human Polyclonal KCNJ1 Primary Antibody für IHC, IHC (p) - ABIN4328476
Vidal-Petiot, Elvira-Matelot, Mutig, Soukaseum, Baudrie, Wu, Cheval, Huc, Cambillau, Bachmann, Doucet, Jeunemaitre, Hadchouel: WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron. in Proceedings of the National Academy of Sciences of the United States of America 2013
Human Polyclonal KCNJ1 Primary Antibody für ELISA, WB - ABIN451810
Ji, Foo, ORoak, Zhao, Larson, Simon, Newton-Cheh, State, Levy, Lifton: Rare independent mutations in renal salt handling genes contribute to blood pressure variation. in Nature genetics 2008
Cow (Bovine) Polyclonal KCNJ1 Primary Antibody für WB - ABIN2776290
Tobin, Tomaszewski, Braund, Hajat, Raleigh, Palmer, Caulfield, Burton, Samani: Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. in Hypertension 2008
Data suggest underlying pathology for some patients with type II Bartter syndrome is linked to stability of ROMK1 in ERAD pathway; using a yeast expression system, cells can be rescued by wild-type (rat) ROMK1 but not by ROMK1 containing any one of four mutations found in (human) type II Bartter syndrome; mutant ROMKs are significantly less stable than wild-type ROMK. (ERAD = endoplasmic reticulum-associated degradation)
WNK4 (zeige WNK4 Antikörper) is a substrate of SFKs and the association of c-Src (zeige SRC Antikörper) and PTP-1D (zeige PTPN11 Antikörper) with WNK4 (zeige WNK4 Antikörper) at Tyr (zeige TYR Antikörper)(1092) and Tyr (zeige TYR Antikörper)(1143) plays an important role in modulating the inhibitory effect of WNK4 (zeige WNK4 Antikörper) on ROMK
knockdown of KCNJ1 in HK-2 (zeige HK2 Antikörper) cells promoted cell proliferation. Collectively, these data highlight that KCNJ1, low-expressed in ccRCC and associated with poor prognosis, plays an important role in ccRCC cell growth and metastasis
The association between polymorphisms in KCNJ1, SLC12A1 (zeige SLC12A1 Antikörper), and 7 other genes and calcium intake and colorectal neoplasia risk was studied.
A KCNJ1 SNP was associated with increased FG during HCTZ treatment.
Molecular analysis revealed a compound heterozygous mutation in the KCNJ1 gene, consisting of a novel K76E and an already described V315G mutation, both affecting functional domains of the channel protein.
Findings suggest that 11q24 is a susceptible locus for openness, with KCNJ1 as the possible candidate gene.
no mutation in the KCNJ1 gene, among patients suffering from bartter and Gitelman syndromes
PI3K (zeige PIK3CA Antikörper)-activating hormones inhibit ROMK by enhancing its endocytosis via a mechanism that involves phosphorylation of WNK1 (zeige WNK1 Antikörper) by Akt1 (zeige AKT1 Antikörper) and SGK1 (zeige SGK1 Antikörper).
THGP (zeige UMOD Antikörper) modulation of ROMK function confers a new role of THGP (zeige UMOD Antikörper) on renal ion transport and may contribute to salt wasting observed in FJHN/MCKD-2 (zeige UMOD Antikörper)/GCKD patients.
The findings support ROMK as the pore-forming subunit of the cytoprotective mitoK(ATP) channel in heart mitochondria.
The results provide evidence that NHERF1 (zeige SLC9A3R2 Antikörper) mediates K(+) current activity through acceleration of the surface expression of ROMK1 K(+) channels in M-1 cells.
ENaC (zeige SCNN1A Antikörper) and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4 (zeige WNK4 Antikörper)(PHAII)-induced inhibition of ENaC (zeige SCNN1A Antikörper) and ROMK may contribute to the suppression of K(+) secretion in the tubules.
The differential regulation of ROMK, large-conductance Ca(2 (zeige CA2 Antikörper)+)-activated K(+) (BK) channel (zeige KCNMA1 Antikörper), BK-alpha and NKCC2 (zeige SLC12A1 Antikörper) between female and male mice, at least, were partly mediated via WNK1 (zeige WNK1 Antikörper) pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.
Suggest that the hyperkalemia in knock-in mouse with the CUL3 (zeige CUL3 Antikörper)(Delta403-459) mutation is not caused by reduced ROMK expression in the distal nephron.
animal knockouts of ROMK1 do not produce Bartter phenotype. ROMK1 is critical in response to high K intake-stimulated K+ secretion in the collecting tubule.
Lovastatin stimulates ROMK1 channels by inducing PI(4,5)P2 synthesis, suggesting that the drug could reduce cyclosporine-induced nephropathy.
ROMK1 protein abundance and activity are down-regulated by SPAK (zeige STK39 Antikörper) and OSR1 (zeige OSR1 Antikörper)
It was concluded that miR (zeige MLXIP Antikörper)-194 regulates ROMK channel activity by modulating ITSN1 (zeige ITSN1 Antikörper) expression thereby enhancing ITSN1 (zeige ITSN1 Antikörper)/WNK-dependent endocytosis.
hypertension resistance sequence variants inhibit ROMK channel function by different mechanisms
Kcnj1 is expressed in cells associated with osmoregulation and acts as a K+ efflux pathway that is important in maintaining extracellular levels of potassium ion in the developing embryo.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
ATP-regulated potassium channel ROM-K
, ATP-sensitive inward rectifier potassium channel 1
, inward rectifier K(+) channel Kir1.1
, inwardly rectifying K+ channel
, potassium channel, inwardly rectifying subfamily J member 1
, potassium inwardly-rectifying channel, subfamily J, member 1
, potassium inwardly-rectifying channel J1
, ATP-sensitive inward rectifier potassium channel 1-like
, K+ channel protein
, Potassium inwardly-rectifying channel subfamily J
, inwardly rectifying potassium channel ROMK-2
, potassium inwardly-rectifying channel, subfamily J, member 15
, LOW QUALITY PROTEIN: ATP-sensitive inward rectifier potassium channel 1