anti-Potassium Channel, Subfamily T, Member 1 (KCNT1) Antikörper

Na(+)-activated potassium channel; may be involved in regulating the firing properties of neurons. Zusätzlich bieten wir Ihnen Potassium Channel, Subfamily T, Member 1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
KCNT1 57582 Q5JUK3
KCNT1 227632 Q6ZPR4
KCNT1 60444 Q9Z258
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Top anti-Potassium Channel, Subfamily T, Member 1 Antikörper auf antikoerper-online.de

Showing 10 out of 72 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Kcnt1 AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Mouse Heart 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert AA, ICC, IF, IHC, WB Slack Rat Brain Membrane Western Blotting. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$383.90
Details
Human Kaninchen Unkonjugiert IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KCNT1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus HRP AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$422.40
Details
Human Maus FITC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$426.80
Details
Human Maus Alkaline Phosphatase (AP) AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$429.00
Details
Human Maus Biotin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$431.20
Details
Human Maus PE AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$432.30
Details
Human Maus Streptavidin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$433.40
Details
Human Maus APC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dotty staining around nucleus and some in cytoplasm. Western Blot analysis of Rat brain membrane lysate showing detection of Slo2.2 Potassium Channel protein using Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody, Clone S3-26 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Slo2.2 Potassium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$434.50
Details

KCNT1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Potassium Channel, Subfamily T, Member 1 Antikörper

  1. Mammalian Monoclonal KCNT1 Primary Antibody für ISt, IHC - ABIN1304961 : Lu, Bausch, Kallenborn-Gerhardt, Stoetzer, Debruin, Ruth, Geisslinger, Leffler, Lukowski, Schmidtko: Slack channels expressed in sensory neurons control neuropathic pain in mice. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)
    Show all 7 Pubmed References

Weitere Antikörper gegen Potassium Channel, Subfamily T, Member 1 Interaktionspartner

Human Potassium Channel, Subfamily T, Member 1 (KCNT1) Interaktionspartner

  1. In the present study, we evaluated two other potential mechanisms for stabilization of Slo2 channels in a closed state: (1) dewetting and collapse of the inner pore (hydrophobic gating) and (2) constriction of the inner pore by tight criss-crossing of the cytoplasmic ends of the S6 alpha-helical segments.

  2. two de novo, heterozygous KCNT1 mutations were identified in two unrelated malignant migrating partial seizures probands. Both mutations induced a marked leftward shift in homomeric channel activation gating.

  3. Better understanding of the mechanisms underlying KCNT1-related disease will produce further improvements in treatment of the associated severe seizure disorders.

  4. We demonstrate that KCNT1 mutations are highly pleiotropic and are associated with phenotypes other than nocturnal frontal lobe epilepsy and malignant migrating focal seizures of infancy.

  5. This study demonstrate that KCNT1 mutations are strongly associated with early-onset epileptic encephalopathy.

  6. Five de novo mutations were identified in four genes (SCNN1A (zeige SCNN1A Antikörper), KCNJ16 (zeige KCNJ16 Antikörper), KCNB2 (zeige KCNB2 Antikörper), and KCNT1) in three Brugada syndrome patients (20%)

  7. Nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel (zeige KCNC4 Antikörper) give rise to three distinct forms of epilepsy.

  8. Slick (zeige KCNT2 Antikörper) channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume.

  9. Genetic studies reveal two novel genes for Ohtahara Syndrome: KCNT1 and PIGQ (zeige PIGQ Antikörper).

  10. Novel variations in KCNT1 do not allow prediction of functional phenotypes that might explain, at least in part, the symptoms of malignant migrating partial seizures of infancy (MMPSI).

Mouse (Murine) Potassium Channel, Subfamily T, Member 1 (KCNT1) Interaktionspartner

  1. The highest Slack channel expression was detected in the olfactory bulb, lateral septal nuclei, basal ganglia, and distinct areas of the midbrain, brainstem, and cerebellar cortex.

  2. The authors find that knockout of Slo2.2, but not Slo2.1, results in enhanced itch and pain responses.

  3. Results provide evidence for a role for endogenous Slack channels in higher brain functions, i.e., learning and memory, cognitive flexibility, locomotoric and the ability to initially respond to novel situations and environments

  4. Global ablation of Slack led to increased hypersensitivity in models of neuropathic pain. Neuropathic pain behaviors were also exaggerated after ablation of Slack selectively in sensory neurons.

  5. partly colocalized with PSD-95 (zeige DLG4 Antikörper) in mouse neocortical neurons

  6. This is the first demonstration of an epithelial cell membrane, Na+-activated, large-conductance K+ channel (zeige KCNC4 Antikörper) resembling K(Na) channels of excitable cells. The Slo2.2 type, Na+- and Cl--activated K+ channel (zeige KCNC4 Antikörper) is located in the ascending limb of the kidney.

  7. Slick (zeige KCNT2 Antikörper) and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation.

Potassium Channel, Subfamily T, Member 1 (KCNT1) Antigen-Profil

Protein Überblick

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit KCNT1

  • potassium channel, subfamily T, member 1 (KCNT1) Antikörper
  • potassium channel, subfamily T, member 1 (kcnt1) Antikörper
  • potassium channel, subfamily T, member 1 (Kcnt1) Antikörper
  • bA100C15.2 Antikörper
  • C030030G16Rik Antikörper
  • EIEE14 Antikörper
  • ENFL5 Antikörper
  • KCa4.1 Antikörper
  • MGC146594 Antikörper
  • MGC172997 Antikörper
  • mKIAA1422 Antikörper
  • rSlo2 Antikörper
  • Slack Antikörper
  • slo2 Antikörper
  • Slo2.2 Antikörper

Bezeichner auf Proteinebene für KCNT1

potassium channel, subfamily T, member 1 , potassium channel subfamily T member 1-like , potassium channel subfamily T member 1 , sodium-activated potassium channel , potassium channel subunit (Slack) , sequence like a calcium-activated potassium channel subunit , potassium channel subunit

GENE ID SPEZIES
100436526 Pongo abelii
100588032 Nomascus leucogenys
464846 Pan troglodytes
491258 Canis lupus familiaris
529468 Bos taurus
779818 Xenopus (Silurana) tropicalis
100016518 Monodelphis domestica
100316919 Xenopus (Silurana) tropicalis
57582 Homo sapiens
227632 Mus musculus
60444 Rattus norvegicus
395248 Gallus gallus
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