Potassium Channel, Subfamily K, Member 3 Proteine (KCNK3)

KCNK3 encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. Zusätzlich bieten wir Ihnen Potassium Channel, Subfamily K, Member 3 Antikörper (79) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
KCNK3 3777 O14649
KCNK3 16527 O35111
Ratte KCNK3 KCNK3 29553 O54912
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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KCNK3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human
,
Mouse (Murine)
,

Weitere Proteine zu Potassium Channel, Subfamily K, Member 3 (KCNK3) Interaktionspartnern

Human Potassium Channel, Subfamily K, Member 3 (KCNK3) Interaktionspartner

  1. Genetic variation in the KCNK3 gene may contribute to Blood pressure variation and less severe Hypertensive disorders in which aldosterone may be one of several causative factors

  2. Knockdown of TASK-1 by siRNA significantly enhanced apoptosis and reduced proliferation in Non-Small Cell Lung Cancer A549 cells, but not in weakly TASK-1 expressing NCI-H358 cells.

  3. The present report supports the contribution of KCNK3 mutations to the genetic etiology of Pulmonary arterial hypertension and strongly suggests that mutations in KCNK3 follow incomplete dominance with worsening of the clinical features in homozygous patients.

  4. In a cohort with idiopathic or hereditary pulmonary arterial hypertension, a possibly associated mutation was found in 11.10% of the idiopathic cases (n = 16) and in 68.18% of the hereditary cases. There were 3 mutations found in KCNK3.

  5. Functional alanine-mutagenesis screens of TASK-1 and TRAAK (zeige KCNK4 Proteine) were used to build an in silico model of the TASK-1 cap.

  6. control of TASK-1 trafficking by COPI, kinases, phosphatases and 14-3-3 (zeige YWHAQ Proteine) proteins is highly dynamic.

  7. KCNK3 expression and function were reduced in pulmonary artery smooth muscle cells and endothelial cells in human pulmonary arterial hypertension.

  8. TASK-1 and TASK-3 (zeige KCNK9 Proteine) may form heterodimers in human atrial cardiomyocytes.

  9. Diacylglycerol mediates regulation of TASK1 and TASK3 potassium channels by GNAQ.

  10. K2P3.1 and K2P9.1 (zeige KCNK9 Proteine) undergo rapid dynamin (zeige DNM1 Proteine)-dependent endocytosis

Mouse (Murine) Potassium Channel, Subfamily K, Member 3 (KCNK3) Interaktionspartner

  1. While there is compelling evidence that TASK-1 is involved in the pathogenesis of pulmonary arterial hypertension in humans, the mouse does not appear to serve as a suitable model to study the underlying molecular mechanisms

  2. the K(+) channel (zeige KCNC4 Proteine) TASK1 controls the thermogenic activity in brown adipocytes through modulation of beta-adrenergic receptor signaling.

  3. KCNK3 channels are not involved in hearing.

  4. An important role for TASK-1 channels in limiting pancreatic alpha-cell excitability and glucagon (zeige GCG Proteine) secretion during glucose stimulation.

  5. A glucose-dependent role for beta-cell TASK-1 channels of limiting glucose-stimulated Deltapsip depolarization and insulin (zeige INS Proteine) secretion, which modulates glucose homeostasis.

  6. Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 (zeige KCNK9 Proteine) channels in mouse carotid body type-1 cells.

  7. This study demonstrated for the first time that oligodendrocytes express functional TASK-1 channels and provide compelling evidence they contribute to oligodendrocyte damage in hypoxia.

  8. TASK-1 deficiency does neither alter key electrophysiological parameters nor increases atrial/ventricular vulnerability after electrical stimulation.

  9. The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1 (zeige KCNJ10 Proteine)), K(2P) channels (TREK-1 (zeige KCNK2 Proteine) and TWIK-1 (zeige KCNK1 Proteine)) and Cl- channels (ClC2 (zeige CLCN2 Proteine)).

  10. No difference is found between the pulmonary artery (PA) of wild-type and TASK-1/3-deficient mice; TASK-1 does not form a functional channel in pulmonary artery smooth muscle cells.

Potassium Channel, Subfamily K, Member 3 (KCNK3) Protein Überblick

Protein Überblick

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.

Genbezeichner und Symbole assoziert mit KCNK3

  • potassium channel, subfamily K, member 3 (kcnk3)
  • potassium channel, subfamily K, member 3 (KCNK3)
  • potassium channel, subfamily K, member 3 (Kcnk3)
  • potassium channel, subfamily K, member 9 (KCNK9)
  • cTBAK-1 Protein
  • K2p3.1 Protein
  • KCNK3 Protein
  • OAT1 Protein
  • PPH4 Protein
  • rTASK Protein
  • si:dkey-164m15.1 Protein
  • TASK Protein
  • Task-1 Protein
  • TBAK1 Protein

Bezeichner auf Proteinebene für KCNK3

potassium channel subfamily K member 3 , TWIK-related acid-sensitive K(+) channel 1 , TWIK-related acid-sensitive K+ channel , acid-sensitive potassium channel protein TASK , acid-sensitive potassium channel protein TASK-1 , cardiac potassium channel , potassium inwardly-rectifying channel, subfamily K, member 3 , two P domain potassium channel , two pore K(+) channel KT3.1 , two pore potassium channel KT3.1 , cardiac two pore background K(+) channel , TASK-1 potassium channel

GENE ID SPEZIES
561866 Danio rerio
3777 Homo sapiens
483002 Canis lupus familiaris
519188 Bos taurus
16527 Mus musculus
29553 Rattus norvegicus
428382 Gallus gallus
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