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This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. Zusätzlich bieten wir Ihnen Polybromo 1 Proteine (12) und Polybromo 1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PBRM1 Primary Antibody für ICC, IF - ABIN256705
Burrows, Smogorzewska, Elledge: Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. in Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Polyclonal PBRM1 Primary Antibody für IP - ABIN256704
Niimi, Chambers, Downs, Lehmann: A role for chromatin remodellers in replication of damaged DNA. in Nucleic acids research 2012
kidney-specific deletion of Vhl (zeige VHL Antikörper) and Pbrm1, but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers.
PBRM1 mutation is associated with small Cell Lung Cancer.
These findings indicate that PBRM1 alters cell cycle progression and inhibits proliferation and migration of renal cell carcinoma (zeige MOK Antikörper) ACHN (zeige LARP6 Antikörper) cells through the chemokine/chemokine (zeige CCL1 Antikörper) receptor pathway.
our integrative analysis suggested that methylation and miRNA alterations were likely the downstream events associated with PBRM1 truncation mutations. In summary, this study provided some important insights into the understanding of tumorigenesis driven by PBRM1 truncated mutations in Clear cell renal cell carcinoma (zeige MOK Antikörper) (ccRCC). The approach may be applied to many driver genes in various cancers.
BAP1 (zeige RNF2 Antikörper) and PBRM1 loss is seen frequently in intrahepatic cholangiocarcinoma
PBRM1 gene deletion is associated with chordoma.
conclude that four of the BDs act together to target PBRM1 to sites on chromatin; when a single BD is mutated, PBRM1 no longer controls gene expression properly, leading to increased cell proliferation
Synthetic lethality screening identifies TIP60 (zeige KAT5 Antikörper)-dependent radiation sensitivity in the absence of BAF180.
Functionally, suppression of PBRM1 expression promoted cell proliferation and cell cycle progression
PBRM1 re-expression led to upregulation of genes involved in cellular adhesion, carbohydrate metabolism, apoptotic process and response to hypoxia, and a downregulation of genes involved in different stages of cell division.
Data suggest BAF180 protein as a critical regulator of cellular senescence and HSC (zeige FUT1 Antikörper) homeostasis, which is at least partially regulated through BAF180-mediated suppression of cell cycle regulator (zeige CDKN2A Antikörper) p21 (zeige D4S234E Antikörper) expression.
Data demonstrate a function for BAF180 in promoting genome stability that is distinct from its well-characterized role in transcriptional regulation.
BAF180 is a repressor of IL-10 (zeige IL10 Antikörper) transcription in Th2 cells and suggest that the differential recruitment of different SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) subtypes can have direct consequences on chromatin structure and gene transcription.
BAF180 is critical for coronary vessel formation.
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.
, protein polybromo-1
, BRG1-associated factor 180
, glutamate receptor interacting protein 2
, polybromo 1 protein