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The protein encoded by PARP3 belongs to the PARP family. Zusätzlich bieten wir Ihnen PARP3 Antikörper (93) und viele weitere Produktgruppen zu diesem Protein an.
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Parp3 is crucial in the early stages of zebrafi (zeige ARHGEF16 Proteine)sh development, possibly by exerting its transcriptional regulatory functions as early as during the specification of the neural plate border
Data indicate that PARP3, a DNA damage-activated ADP-ribosyltransferase, can mono-ADP-ribosylate double-stranded DNA ends.
In a process of single-strand DNA repair, PARP3 mono-ADP-ribosylates nucleosomal histone H2B.
we found that PARP3 interacted with FoxM1 (zeige FOXM1 Proteine) to enhance its transcriptional activity and conferred glioblastoma cell radioresistance. Thus, our data suggest that PARP3 could be a therapeutic target to overcome radioresistance in glioblastoma
Identification of ADP-ribosylation sites in PARP3 and the determination of the extent ofpoly(ADP-ribosyl)ated residues in this protein was performed.
MiR (zeige MLXIP Proteine)-630 reduced apoptosis by downregulating several apoptotic modulators, PARP3, DDIT4 (zeige DDIT4 Proteine), and EP300 (zeige EP300 Proteine).
In some cancer cells, repression of PARP3 could be responsible for an increased telomerase activity.
PARP3 likely facilitates the recruitment of Ku80 (zeige XRCC5 Proteine) to double strand breaks to antagonize DNA end resection but facilitate Ku-mediated accurate classical non-homologous end-joining.
PARP3 gene occupancy in the human neuroblastoma (zeige ARHGEF16 Proteine) cell line SK-N-SH occurs preferentially with developmental genes regulating cell fate specification, tissue patterning, craniofacial development and neurogenesis.
PARP3 is a critical player in the stabilization of the mitotic spindle and in telomere integrity by associating and regulating the mitotic components NuMA and tankyrase 1 (zeige TNKS Proteine).
PARP-3 has a role in chromosomal DNA double-strand break repair.
We show that Poly(ADP)ribose polymerase 3 (Parp3), an enzyme recently implicated in DNA repair, contributes to antibody diversification by negatively regulating class switch recombination without affecting somatic hypermutation.
We cloned and sequenced the cDNAs of the mouse PARP-3 (Adprt3) gene encoding poly(ADP-ribose) polymerase 3 and of the closely linked U3-55k (zeige RRP9 Proteine) gene coding for the U3 small nucleolar ribonucleoprotein complex-associated 55-kilodalton protein.
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
NAD(+) ADP-ribosyltransferase 3
, poly [ADP-ribose] polymerase 3
, poly[ADP-ribose] synthase 3
, ADP-ribosyltransferase (NAD+; poly (ADP-ribose polymerase)-like 3
, poly (ADP-ribose) polymerase family, member 3
, Poly synthetase 3
, poly [ADP-ribose] polymerase 3-like
, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2
, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3
, ADP-ribosyltransferase diphtheria toxin-like 3
, NAD+ ADP-ribosyltransferase 3
, poly(ADP-ribose) synthetase-3
, poly[ADP-ribose] synthetase 3
, A DP-ribosyltransferase (NAD+; poly (ADP-ribose polymerase)-like 3
, ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3
, Poly[ADP-ribose] synthetase-3
, poly (ADP-ribosyl) transferase-like 3