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This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. Zusätzlich bieten wir Ihnen PCBP1 Proteine (9) und PCBP1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 117 products:
Human Polyclonal PCBP1 Primary Antibody für ELISA, WB - ABIN562120
Neff, Lee, Wilusz, Tian, Wilusz: Global analysis reveals multiple pathways for unique regulation of mRNA decay in induced pluripotent stem cells. in Genome research 2012
Show all 3 Pubmed References
Human Monoclonal PCBP1 Primary Antibody für IF, ELISA - ABIN518653
Link, Howley, Hussey, Howe: PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. in Molecular cancer research : MCR 2016
Cow (Bovine) Polyclonal PCBP1 Primary Antibody für IHC, WB - ABIN2778971
Shi, Bencze, Stemmler, Philpott: A cytosolic iron chaperone that delivers iron to ferritin. in Science (New York, N.Y.) 2008
Human Polyclonal PCBP1 Primary Antibody für ELISA, WB - ABIN4344018
Waggoner, Johannes, Liebhaber: Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. in The Journal of biological chemistry 2009
Study report a novel interaction between mutant HSPB1 (zeige HSPB1 Antikörper)-P182L and the RNA binding protein (zeige PTBP1 Antikörper) PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 (zeige HSPB1 Antikörper) in neurodegenerative diseases.
It is reported here that TGF-beta (zeige TGFB1 Antikörper) directly regulates alternative splicing of cancer stem cell marker CD44 (zeige CD44 Antikörper) through a phosphorylated threonine179 of SMAD3 (zeige SMAD3 Antikörper)-mediated interaction with RNA-binding protein (zeige PTBP1 Antikörper) PCBP1.
our findings suggest that PCBP1 is a molecular marker of oxaliplatin resistance in colorectal cancer
Data suggest a 216-nucleotide proximal cis (zeige CISH Antikörper)-element in LIF (zeige LIF Antikörper) mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (zeige CISH Antikörper)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (zeige NCL Antikörper) and PCBP1, 2 trans-acting factors that bind to and stabilize LIF (zeige LIF Antikörper) mRNA. [LIF (zeige LIF Antikörper) = leukemia inhibitory factor (zeige LIF Antikörper); PCBP1 = poly(rC) binding protein 1]
It was concluded that a novel positive feedback loop amplifies hnRNP-E1 during prolonged folate deficiency and thereby maximizes upregulation of folate receptors in order to restore folate homeostasis toward normalcy in placental cells.
TGF-beta (zeige TGFB1 Antikörper) signaling through Akt2 (zeige AKT2 Antikörper) induces phosphorylation of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1), driving epithelial to mesenchymal transition and metastasis.
These results establish the role of hnRNP K and PCPB1 in the translational control of morphine-induced MOR expression in human neuroblastoma (NMB) cells as well as cells stably expressing MOR (NMB1).
The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1 (zeige TIA1 Antikörper), Pcbp1, and RBM39 (zeige RBM39 Antikörper) stabilizes or increases U2 snRNP (zeige LSM2 Antikörper) recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39 (zeige RBM39 Antikörper)-mediated splicing regulation.
BC200 RNA interacts with hnRNP E1 and E2 mainly through its unique 3' C-rich domain.
Low expression of PCBP1 is associated with lung cancer metastasis.
Study report a novel interaction between mutant HSPB1 (zeige HSPB1 Antikörper)-P182L and the RNA binding protein PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 (zeige HSPB1 Antikörper) in neurodegenerative diseases.
These studies demonstrate the importance of ferritin (zeige FTL Antikörper) for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 (zeige NCOA4 Antikörper) in mediating iron flux through ferritin (zeige FTL Antikörper).
Pcbp1 modulated the processing of muscle-enriched miR-1, miR (zeige MLXIP Antikörper)-133, and miR (zeige MLXIP Antikörper)-206 by physically interacting with argonaute 2 (AGO2 (zeige EIF2C2 Antikörper)) and other miRNA pathway components.
These data reveal that Pcbp1 and Pcbp2 (zeige PCBP2 Antikörper) are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.
PCBP1 may serve as a novel maternal factor (zeige ZAR1 Antikörper).
Our analysis of PCBP1 and PCBP2 (zeige PCBP2 Antikörper) expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.
knockdown of PCBP1 led to a reversal effect on the transcriptional inactivation during oocyte growth, which highlights the important role of PCBP1 in maintaining the gobal transcriptional silencing when the growth phase is completed
TGF-beta (zeige TGFB1 Antikörper) modulates the expression of Dab2 (zeige DAB2 Antikörper) and ILEI (zeige FAM3C Antikörper) mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT (zeige BAAT Antikörper) element in the 3'UTR (zeige UTS2R Antikörper) of Dab2 (zeige DAB2 Antikörper) and ILEI (zeige FAM3C Antikörper).
To define the mechanism of STAT3C suppression of transcript. and/or translational activity of NF-kappaB (zeige NFKB1 Antikörper) we found that a alphaCP-1 interacted with STAT3C. alphaCP-1 is a K-homol. domain-containing RNA-binding prot (zeige SLC6A7 Antikörper) with specific for C-rich pyrimidine tracts
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
poly(rC) binding protein 1
, poly(rC)-binding protein 1-like
, heterogeneous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein X
, nucleic acid-binding protein SUB2.3
, poly(rC)-binding protein 1
, hnRNP-E1 protein
, hnRNP E1