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PABPC1 encodes a poly(A) binding protein. Zusätzlich bieten wir Ihnen Poly(A) Binding Protein, Cytoplasmic 1 Antikörper (75) und Poly(A) Binding Protein, Cytoplasmic 1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
Data suggest that DEAD-box helicase 3 (DDX3X (zeige DDX3X ELISA Kits)) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (zeige DDX3X ELISA Kits) (via gene silencing with the CRISPR-Cas (zeige CSE1L ELISA Kits) system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line.
Data suggest that hnRNPLL (zeige HNRPLL ELISA Kits) specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL (zeige HNRPLL ELISA Kits) to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL (zeige HNRPLL ELISA Kits) = heterogeneous nuclear ribonucleoprotein L-like (zeige HNRPLL ELISA Kits) protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)
PABP enhances the productive binding of the eRF1-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a which itself has an active role in translation termination.
Unr (zeige P2RY4 ELISA Kits) stimulated the binding of PABP1 to mRNA, and that Unr (zeige P2RY4 ELISA Kits) was required for the stable interaction of PABP1 and eIF4G (zeige EIF4G1 ELISA Kits) in cells.
PABPC1 decreased expression in in infertile men with non-obstructive azoospermia
BTG2 (zeige BTG2 ELISA Kits) stimulates mRNA deadenylation via CAF1 (zeige CHAF1B ELISA Kits) activation through interaction with PABPC1. Interaction of BTG2 (zeige BTG2 ELISA Kits) with the first RRM domain of PABPC1 is required for BTG2 (zeige BTG2 ELISA Kits) to control cell proliferation.
PABPC1 is a novel co-regulator of the AR
PABPC1 is upregulated in gastric carcinoma tissues, and high PABPC1 expression predicts poor survival. PABPC1 regulates proliferation and transformation of gastric cancer cells in vitro and in vivo. PABPC1 knockdown induces apoptosis.
PABPC1 interacts with AGO2 (zeige EIF2C2 ELISA Kits) and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma.
Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus
Superovulation with low or high doses of gonadotropins significantly altered Epab and Pabpc1 mRNA levels in GV oocytes, MII oocytes and 1- and 2-cell embryos compared with their respective controls. These changes most likely lead to variations in expression of EPAB- and PABPC1-regulated genes, which may adversely influence the quality of oocytes and early embryos retrieved using superovulation.
Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr (zeige EGFR ELISA Kits) signaling.
Epab(-/-) oocytes are smaller in size, contain peripheral germinal vesicles, and are loosely associated with cumulus cells
These findings suggest that EPAB may predominantly play roles in translational regulation of the mRNAs during early oogenesis and folliculogenesis, but PABPC1 most likely perform these roles in the later terms of ovarian development along with EPAB
Epab is dispensable for mouse spermatogenesis and male fertility.
We analyzed the expression of sperm-specific Akap3 (zeige AKAP3 ELISA Kits) and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.
Both Epab and Pabpc1 expression increase during early postnatal life and reach their peak at D32 testis.
our data support the concept that expanded ATXN2 (zeige ATXN2 ELISA Kits) undergoes progressive insolubility and affects PABPC1 by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8 (zeige FBXW8 ELISA Kits).
EPAB is necessary for oogenesis, folliculogenesis and female fertility in mice.
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation\; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.
polyadenylate-binding protein 1-like
, poly(A) binding protein, cytoplasmic 1
, polyadenylate-binding protein 1
, PABP 1-A
, cytoplasmic poly(A)-binding protein 1-A
, poly(A)-binding protein 1-A
, polyadenylate-binding protein 1-A
, poly(A) binding protein, cytoplasmic 2
, PABP 1
, poly(A)-binding protein 1
, poly A binding protein 1