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The protein encoded by PLK2 is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. Zusätzlich bieten wir Ihnen Polo-Like Kinase 2 Proteine (12) und Polo-Like Kinase 2 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PLK2 Primary Antibody für ELISA, WB - ABIN564696
Kristl, Slanc, Krasna, Berlec, Jeras, Strukelj: Calcipotriol affects keratinocyte proliferation by decreasing expression of early growth response-1 and polo-like kinase-2. in Pharmaceutical research 2008
Show all 2 Pubmed References
Plk2 represents an independent prognostic marker and regulates tumor growth and apoptosis by targeting Fbxw7 (zeige FBXW7 Antikörper)/Cyclin E (zeige CCNE1 Antikörper) pathway in colorectal carcinoma.
PLK2 kinase has a role in mediating alpha-synuclein (zeige SNCA Antikörper) selective autophagic degradation
PLK2, functional kinase and polo (zeige PLK1 Antikörper)-box domains were required for interaction with PFV Gag. Fluorescently-tagged PFV Gag, through its chromatin tethering function, selectively relocalized ectopically expressed eGFP-tagged PLK (zeige PLK1 Antikörper) proteins to mitotic chromosomes i
Develop a DDS for continuous intracellular delivery of PLK2.
Structural analysis of the polo (zeige PLK1 Antikörper)-box domain of human PLK2 has been presented.
our study demonstrates a novel mechanism of PLK2 in promoting tumor progression, whereby it directly binds to enriched TAp73 (zeige TP73 Antikörper), catalyzes Ser48 phosphorylation of TAp73 (zeige TP73 Antikörper), and inhibits TAp73 (zeige TP73 Antikörper) transcriptional activity
Data suggest wild-type SNCA (alpha-synuclein (zeige SNCA Antikörper)) binding to synaptosome membrane is not affected by phosphorylation by PLK2; A30P SNCA (zeige SNCA Antikörper), a Parkinson disease mutation, binding is greatly increased; endocytosis of SNCA (zeige SNCA Antikörper) fibrils follows similar pattern.
Decreased PLK2 protein expression due to promoter hypermethylation was negatively correlated with JAK2 (zeige JAK2 Antikörper) overexpression, a common occurrence in hematological malignancies.
PLK2 SNPs were associated with Alzheimer disease and mild cognitive impairment. PLK2-rs15009 CC and GG genotypes and CC genotype at PLK2-rs702723 were protective for AD.
PLK2 indirectly activates ROCK2 (zeige ROCK2 Antikörper) via phosphorylating nucleophosmin (zeige NPM1 Antikörper) during centrosome amplification.
miR (zeige MLXIP Antikörper)-146a regulates lineage negative bone marrow cell senescence and apoptosis by suppressing Plk2 expression that, in turn, activates p16Ink4a/p19Arf (zeige CDKN2A Antikörper) and p53 (zeige TP53 Antikörper) signaling.
These results support a significant role for a PLK (zeige PLK1 Antikörper) kinase in phosphorylating alpha-synuclein (zeige SNCA Antikörper) at Ser129 in the brain, and suggest that PLK2 is responsible for this activity under physiological conditions.
In support of a tumor suppressor function for Plk2, loss of Plk2 increased the formation of lesions in multiparous glands. Collectively, these results demonstrate a novel role for Plk2 in regulating mammary gland development.
c-Fos and polo-like kinase 2 induction is impaired in the limbic system of fear-conditioned alpha-synuclein (zeige SNCA Antikörper) transgenic mice
PLK2 inhibition is a tractable CNS pharmacological target that does not cause genotoxicity at doses and exposures that engage the target in the sensory retina.
perturbation of Plk2 disrupts Ras and Rap (zeige LRPAP1 Antikörper) signaling, prevents homeostatic shrinkage and loss of dendritic spines, and impairs proper memory formation.
CIB co-immunoprecipitated with Snk and inhibited the kinase activity of Snk, suggesting that CIB is a negative regulator for Snk kinase activity.
there is a mitotic checkpoint (zeige BUB3 Antikörper) wherein p53 (zeige TP53 Antikörper)-dependent activation of Snk/Plk2 prevents mitotic catastrophe following spindle damage
PLK2 directly phosphorylates alpha-synuclein (zeige SNCA Antikörper) at Ser (zeige SIGLEC1 Antikörper)-129 in an in vitro biochemical assay
Here we show that CHK-2 promotes pairing and synapsis by phosphorylating a family of zinc finger proteins that bind to specialized regions on each chromosome known as pairing centers, priming their recruitment of the Polo-like kinase PLK (zeige PLK1 Antikörper)-2.
Polo (zeige PLK1 Antikörper) kinases, via their polo (zeige PLK1 Antikörper) box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX (zeige ZSWIM2 Antikörper)-6.
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, serine/threonine-protein kinase PLK2
, serine/threonine-protein kinase SNK
, serum-inducible kinase
, polo-like kinase 1
, polo-like kinase 2 (Drosophila)
, polo-like kinase 2
, Serine/threonine-protein kinase PLK2
, serine/threonine-protein kinase PLK2-like