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Plxna2 encodes a member of the plexin-A family of semaphorin co-receptors. Zusätzlich bieten wir Ihnen Plexin A2 Antikörper (47) und Plexin A2 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.
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Human Plxna2 Protein expressed in Wheat germ - ABIN1315496
Kunath, Delaroque, Szardenings, Neundorf, Straub: Sympathetic nerve repulsion inhibited by designer molecules in vitro and role in experimental arthritis. in Life sciences 2016
Sema6a (zeige SEMA6A Proteine) and Plxna2 have roles in promoting eye vesicle cohesion through mediating spatially regulated repulsion within the developing zebrafish eye
Data indicate that plexin A1 (zeige PLXNA1 Proteine)-4 (PLXNA1 (zeige PLXNA1 Proteine)-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
although plexin-A4 (zeige PLXNA4 Proteine) overexpression restored Sema3A (zeige SEMA3A Proteine) signaling in plexin-A1 (zeige PLXNA1 Proteine)-silenced cells, it failed to restore Sema3B (zeige SEMA3B Proteine) signaling in plexin-A2-silenced cells.
PLXNA2 upregulation contributes to TMPRSS2 (zeige TMPRSS2 Proteine):ERG (zeige ERG Proteine)-mediated enhancements of PC3c cell migration and invasion.
PLXNA2 has been identified as a new rare copy number variations gene for tetralogy of Fallot.
results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 (zeige BMP2 Proteine) signaling
PLXNA2 polymorphisms show association with ankylosing spondylitis.
in vitro analysis of PLXNA2 revealed that the gene has higher expression in more aggressive breast cancer cell types.
An association is identified between variants in the PLXNA2 gene and schizophrenia in two collections of schizophrenia cases and controls. High-density SNP mapping showed that the region of association spans approximately 60 kb of the PLXNA2 gene.
results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample
PLXNA2 confers a varying genetic risk for schizophrenia among different populations.
Using time-lapse videomicroscopy we provide evidence that Sema6A (zeige SEMA6A Proteine)/PlexinA2 signaling participates to interkinetic nuclear migration of retinal progenitor cell
Plexin A2 is expressed in both On and Off starburst amacrine cell.
crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1 (zeige PLXNB1 Proteine)(1-2)-SEMA4D (zeige SEMA4D Proteine)(ecto (zeige TRIM33 Proteine)) and murine PlxnA2(1-4)-Sema6A (zeige SEMA6A Proteine)(ecto (zeige TRIM33 Proteine))), plus unliganded structures of PlxnA2(1-4) and Sema6A (zeige SEMA6A Proteine)(ecto (zeige TRIM33 Proteine))
crystal structures of the semaphorin 6A (Sema6A (zeige SEMA6A Proteine)) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states
This study demonstrated that Sema6B (zeige SEMA6B Proteine), another class 6 transmembrane semaphorin, is expressed in CA3 (zeige CA3 Proteine) and repels mossy fibers in a PlxnA4 (zeige PLXNA4 Proteine)-dependent manner in vitro.
In plexin-A2-deficient mice many granule cells remained in the molecular layer; mouse chimera studies further suggested that plexin-A2 acts in a cell-autonomous manner.
mutations in GATA6 (zeige GATA6 Proteine) are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C (zeige SEMA3C Proteine)-plexin A2 signaling
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.
, plexin A2
, plexin 2
, semaphorin receptor OCT
, transmembrane protein OCT
, plex 2