Piwi-Like 4 (Drosophila) Proteine (PIWIL4)

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen PIWIL4 Antikörper (72) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PIWIL4 143689 Q7Z3Z4
PIWIL4 330890 Q8CGT6
Ratte PIWIL4 PIWIL4 689972  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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PIWIL4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Piwi-Like 4 (Drosophila) (PIWIL4) Interaktionspartnern

Human Piwi-Like 4 (Drosophila) (PIWIL4) Interaktionspartner

  1. PIWIL2 and PIWIL4 genes expression in synovial fibroblasts of the rheumatoid arthritis patients.PIWIL4 does not regulate methylation or expression of LINE-1.

  2. MiR (zeige MLXIP Proteine)-384 functioned as tumor suppressor by decreasing PIWIL4 in glioma cell lines.

  3. study demonstrates the presence of PIWI (zeige PIWIL1 Proteine)-like proteins in somatic cells and the possible role of HIWI2 in preserving the functional integrity of epithelial cells probably by modulating the phosphorylation status of Akt (zeige AKT1 Proteine).

  4. PIWIL4 is highly expressed in both breast cancer tissues and the cytoplasm of MDA-MB-231 cells derived from breast cancer. Reducing PIWIL4 expression drastically impairs the migration ability of MDA-MB-231 cells, significantly increases their apoptosis, and mildly affects their proliferation.

  5. Results show that three CpG loci within FYN (zeige FYN Proteine) were hypermethylated in obese individuals, while obesity was associated with lower methylation of CpG loci within PIWIL4 and TAOK3 (zeige TAOK3 Proteine).

  6. study to evaluate frequency of PIWIL4 genetic variants in order to better define the relationship between PIWIL4 SNPs and defective spermatogenesis and specific spermatogenic disorders; results suggest genetic and epigenetic alterations that affect the PIWI pathway contribute to unsuccessful sperm production

  7. Data suggest that MIWI2 and MIWI2-associated piRNAs have functions beyond TE suppression.

  8. associations were determined between the Piwi-like family member expression levels and clinicopathological parameters of ccRCC, suggesting a potential role for these genes/proteins in ccRCC diagnostics and tumorigenesis

  9. we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients.

  10. PIWIL4 might play an oncogenic role in cervical cancer

Mouse (Murine) Piwi-Like 4 (Drosophila) (PIWIL4) Interaktionspartner

  1. Miwi2 deficiency had only a minor impact on piRNA biogenesis. Miwi2-knockout mice indicated overexpression of several LINE1 TE families.

  2. piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.

  3. MIWI2 is not solely necessary for hematopoiesis within the normal life span of a mouse.

  4. Mice with a global deletion of all three piwi (zeige PIWIL1 Proteine) genes, Miwi (zeige PIWIL1 Proteine), Mili, and Miwi2, are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.

  5. Icariin induced a decrease in piwil4 protein expression and piwil4 silencing significantly enhanced the cytotoxic effects of icariin in MLTC-1 cells.

  6. Results identify TDRD9 as a functional partner of MIWI2 and indicate that the tudor-piwi association is a conserved feature, while two separate axes, TDRD9-MIWI2 and TDRD1-MILI, cooperate in the piwi-small RNA pathway in the mouse male germline.

  7. Data strongly suggest that MILI and MIWI2 play essential roles in establishing de novo DNA methylation (zeige HELLS Proteine) of retrotransposons in fetal male germ cells.

  8. purified the three murine Piwi (zeige PIWIL1 Proteine) family proteins, MILI, MIWI (zeige PIWIL1 Proteine), and MIWI2, from mouse germ cells and characterized their interacting protein partners

PIWIL4 Protein Überblick

Protein Überblick

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003

Genbezeichner und Symbole assoziert mit PIWIL4

  • piwi-like 4 (Drosophila) (PIWIL4)
  • piwi-like RNA-mediated gene silencing 4 (PIWIL4)
  • piwi-like RNA-mediated gene silencing 4 (Piwil4)
  • 9230101H05Rik Protein
  • HIWI2 Protein
  • Miwi2 Protein

Bezeichner auf Proteinebene für PIWIL4

piwi-like 4 , piwi-like protein 4 , mAgo5 , piwi-like homolog 4

GENE ID SPEZIES
485123 Canis lupus familiaris
143689 Homo sapiens
330890 Mus musculus
689972 Rattus norvegicus
509545 Bos taurus
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