Piwi-Like 1 (Drosophila) Proteine (PIWIL1)

PIWIL1 encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. Zusätzlich bieten wir Ihnen Piwi-Like 1 (Drosophila) Antikörper (73) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PIWIL1 9271 Q96J94
PIWIL1 57749 Q9JMB7
Ratte PIWIL1 PIWIL1 363912  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
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PIWIL1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Piwi-Like 1 (Drosophila) (PIWIL1) Interaktionspartnern

Medaka Piwi-Like 1 (Drosophila) (PIWIL1) Interaktionspartner

  1. piwi plays a generally conserved role in germ cell development in Oryzias latipes.

Zebrafish Piwi-Like 1 (Drosophila) (PIWIL1) Interaktionspartner

  1. the zebrafish homologue of the Drosophila piwi: co-localization with vasa (zeige DDX4 Proteine) at the embryonic genital ridge and gonad-specific expression in the adults (ziwi protein).

  2. Tdrd1 (zeige TDRD1 Proteine) acts as a molecular scaffold for Ziwi.

  3. Promoter activity of a 4.8-kb sequence isolated from the 5' end of the zebrafish germ cell-specific ziwi gene is sufficient to drive gene expression in all germ cells with stage-specific differences in expression levels.

  4. study demonstrated that zebrafish Piwi, Ziwi is expressed in gonad of both sexes and is a component of a structure called nuage; loss of Ziwi function results in a progressive loss of germ cells due to apoptosis during larval development

  5. Ziwi and Zili bind piRNAs of opposite polarity

Pig (Porcine) Piwi-Like 1 (Drosophila) (PIWIL1) Interaktionspartner

  1. Data show that Piwil1 and Piwil2 are mapped together onto the chromosome 14, at the q14 and q11 respectively.

Human Piwi-Like 1 (Drosophila) (PIWIL1) Interaktionspartner

  1. Findings identify Piwi as a factor in human infertility and reveal its role in regulating the histone-to-protamine exchange during spermiogenesis.

  2. In blood serum, piR (zeige PIR Proteine)-823 is up-regulated, but with unsatisfactory analytical performance. Preliminary data indicate the promising diagnostic utility of urinary piR (zeige PIR Proteine)-823 in patients with RCC (zeige XRCC1 Proteine)

  3. Overexpression of Hiwi significantly suppressed cell proliferation and cell migration and induced apoptosis in K562 cells.

  4. Hiwi upregulation enhanced chemosensitivity of Chronic Myeloid Leukemia (zeige BCL11A Proteine) cells to daunomycin, suppressed cell proliferation and promoted apoptosis.

  5. HIWI promotes the activity of breast cancer cells while depression of HIWI may induce apoptosis of breast cancer cells.

  6. Our study reveals a novel mechanism for PIWIL1 in tumorigenesis.

  7. PIWIL1 expression emerged as an independent prognostic marker in non-small cell lung cancer.

  8. Among patients with high let-7a expression, those with medium HIWI had an increased risk of death compared to those with low HIWI (HR = 2.62, 95% CI: 1.30-5.30).

  9. results suggested that Piwil1 caused the loss of PTEN expression through DNMT1-mediated PTEN hypermethylation

  10. Results show that HIWI is highly expressed in high-grade squamous intraepithelial lesions and cervical cancer tissues suggesting its participation in the carcinogenesis of cervical cancer.

Cow (Bovine) Piwi-Like 1 (Drosophila) (PIWIL1) Interaktionspartner

  1. full-length transcript present in testes, not in oocytes or early embryos; two shorter isoforms, PL1 (zeige PRL3D1 Proteine)-10 and PL1 (zeige PRL3D1 Proteine)-13, expressed in oocytes and early embryos

Mouse (Murine) Piwi-Like 1 (Drosophila) (PIWIL1) Interaktionspartner

  1. MIWI (or PIWIL1) depletion had a smaller effect. In oocytes lacking PLD6 (zeige PLD6 Proteine) (or ZUCCHINI or MITOPLD (zeige PLD6 Proteine)), a mitochondrial nuclease (zeige DCLRE1C Proteine)/phospholipase involved in piRNA biogenesis in male germ cells, the piRNA level was decreased to 50% compared to wild-type.

  2. Stem cell protein (zeige TAL1 Proteine) Piwil1 plays an important role in regulating stem-like properties of endometrial cancer cells.

  3. piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.

  4. PIWIL1 regulates neuronal polarization and radial migration partly via modulating the expression of microtubule-associated proteins.

  5. Results show that HIWI is highly expressed in high-grade squamous intraepithelial lesions and cervical cancer tissues suggesting its participation in the carcinogenesis of cervical cancer.

  6. We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.

  7. Mice with a global deletion of all three piwi genes, Miwi, Mili, and Miwi2 (zeige PIWIL4 Proteine), are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.

  8. Miwi protein might be an important functional protein in murine folliculogenesis

  9. The in vitro studies show estrogen can downregulate the expression of miwi and mili.

  10. characterize the genome-wide target RNA repertoire of Mili (Piwil2) and Miwi (Piwil1), two Piwi proteins expressed in postnatal testis

Piwi-Like 1 (Drosophila) (PIWIL1) Protein Überblick

Protein Überblick

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PIWIL1

  • piwi like RNA-mediated gene silencing 1 (PIWIL1)
  • PIWI-like protein 1 (Tb10.70.5520)
  • putative PIWI-like protein 1 (LINJ_21_0470)
  • putative argonaut-like protein (LBRM_21_0470)
  • piwi like RNA-mediated gene silencing 1 (piwil1)
  • piwi-like RNA-mediated gene silencing 1 (piwil1)
  • piwi-like RNA-mediated gene silencing 1 (Piwil1)
  • HIWI Protein
  • MIWI Protein
  • PIWI Protein
  • ziwi Protein

Bezeichner auf Proteinebene für PIWIL1

piwi-like 1 (Drosophila) , PIWI-like protein 1 , argonaut-like protein , piwi-like protein 1 , piwi homolog , piwi-like 1 , piwi-like protein 1-like , piwi like homolog 1 , piwi-like homolog 1

GENE ID SPEZIES
452369 Pan troglodytes
3662385 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5068770 Leishmania infantum JPCM5
5415312 Leishmania braziliensis MHOM/BR/75/M2904
100301587 Oryzias latipes
368200 Danio rerio
477440 Canis lupus familiaris
100499508 Sus scrofa
416804 Gallus gallus
9271 Homo sapiens
537833 Bos taurus
57749 Mus musculus
363912 Rattus norvegicus
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