Pituitary Tumor-Transforming 1 Proteine (PTTG1)

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. Zusätzlich bieten wir Ihnen PTTG1 Antikörper (77) und PTTG1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTTG1 9232 O95997
PTTG1 64193 P97613
PTTG1 30939 Q9CQJ7
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Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$407.00
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,489.67
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Hefe Schizosaccharomyces pombe His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,799.50
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,240.33
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,480.50
Details
Hefe Pan troglodytes His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,489.67
Details

PTTG1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
,

Weitere Proteine zu Pituitary Tumor-Transforming 1 (PTTG1) Interaktionspartnern

Human Pituitary Tumor-Transforming 1 (PTTG1) Interaktionspartner

  1. Findings indicate that PBF (zeige PTTG1IP Proteine) and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.

  2. PTTG-mediated FGF2 (zeige FGF2 Proteine) upregulation is associated with more aggressive tumor features in patients with acromegaly. Also, locally produced estrogen through aromatization might have a role in this phenomenon.

  3. All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain, which may mediate the intermolecular recognition between hPTTG1 and MAP3K.

  4. that PTTG1 is a novel downstream target gene of androgen receptor (zeige AR Proteine) and take part in prostate cancer proliferation and metastasis

  5. Knockdown of PTTG1 suppresses the growth and invasion of LAC (zeige LCT Proteine) cells through upregulation of the TGFbeta1 (zeige TGFB1 Proteine)/SMAD3 (zeige SMAD3 Proteine) signaling.

  6. PTTG1 is correlated with non-small cell lung cancer (NSCLC) progression and as an independent poor prognostic factor in NSCLC patients.

  7. Our data indicate that securin expression may serve as a strong and independent prognosticator of breast cancer outcome

  8. PTTG1 mRNA expression levels in gastric tumor tissues were significantly higher than in the corresponding adjacent normal gastric mucosa.PTTG1 mRNA and protein expression are independent prognostic factors for gastric cancer patient survival.

  9. Pttg1 may increase BC cell growth through nuclear exclusion of p27 (zeige PAK2 Proteine), which highlights a novel molecular regulatory machinery in tumorigenesis of BC.

  10. Data show that overexpression of c-myc proto-oncogene (zeige MYC Proteine) protein (zeige MYC Proteine) could prevent the metabolic shift induced by pituitary tumor-transforming gene (PTTG) knockwown.

Pig (Porcine) Pituitary Tumor-Transforming 1 (PTTG1) Interaktionspartner

  1. PTTG1 is a new candidate maternal effect gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis

Mouse (Murine) Pituitary Tumor-Transforming 1 (PTTG1) Interaktionspartner

  1. High PTTG1 expression is associated with pituitary tumor development.

  2. PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.

  3. RasGrf1 (zeige RASGRF1 Proteine) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.

  4. these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.

  5. Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis

  6. PBF (zeige PTTG1IP Proteine) is the first protein to interact with the critical TH transporter MCT8 (zeige MCT8 Proteine) and modulate its function in vivo

  7. CSN3 (zeige CSN3 Proteine) and CSN5 (zeige COPS5 Proteine) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (zeige CCNB1 Proteine) and Securin via APC (zeige APC Proteine)/C.

  8. The genetically deleting Tff3 (zeige TFF3 Proteine) in mice altered down-regulated Pttg1 and up-regulated serpina3n (zeige SERPINA3N Proteine) expression, indicating a potential role of these factors during the development of presbyacusis.

  9. data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function

  10. Pituitary tumor transforming gene 1 (PTTG1), an oncogene (zeige RAB1A Proteine), was the most up-regulated transcript in KLF6 (zeige KLF6 Proteine)+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6 (zeige KLF6 Proteine).

PTTG1 Protein Überblick

Protein Überblick

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Genbezeichner und Symbole assoziert mit PTTG1

  • pituitary tumor-transforming 1 (PTTG1)
  • pituitary tumor-transforming 1 pseudogene (LOC510673)
  • pituitary tumor-transforming 1 pseudogene (LOC539883)
  • pituitary tumor-transforming 1 (Pttg1)
  • pituitary tumor-transforming gene 1 (Pttg1)
  • AW555095 Protein
  • C87862 Protein
  • EAP1 Protein
  • HPTTG Protein
  • Pttg Protein
  • PTTG1 Protein
  • Pttg3 Protein
  • Securin Protein
  • TUTR1 Protein

Bezeichner auf Proteinebene für PTTG1

pituitary tumor-transforming protein 1 , securin , pituitary tumor-transforming 1 , ESP1-associated protein 1 , pituitary tumor-transforming gene 1 protein , tumor-transforming protein 1 , Pituitary tumor transforming

GENE ID SPEZIES
416158 Gallus gallus
479307 Canis lupus familiaris
510673 Bos taurus
539883 Bos taurus
696143 Macaca mulatta
9232 Homo sapiens
64193 Rattus norvegicus
397015 Sus scrofa
508043 Bos taurus
462238 Pan troglodytes
30939 Mus musculus
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