Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase Proteine (GART)

The protein encoded by GART is a trifunctional polypeptide.

alle Proteine anzeigen Gen GeneID UniProt
Maus GART GART 14450 Q64737
Ratte GART GART 288259  
Human GART GART 2618 P22102
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Weitere Proteine zu Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase (GART) Interaktionspartnern

Human Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase (GART) Interaktionspartner

  1. The minor A allele of rs7279549 of GART is a functional risk factor for congenital heart disease in Shandong population.

  2. most significant association was detected for GART rs8971. Compared with individuals with the TT genotype, the age- and sex-adjusted odds ratio (OR) for developing HCC (zeige FAM126A Proteine) was 1.44 (95% confidence interval (CI): 1.03-2.02) among those with the CC genotype

  3. The current results showed that GART expression was associated with glioma grade and that high GART protein expression might be related to poor outcome.

  4. our clinical and in vitro data indicate that GART expression may be one of the causative factors for a poor prognosis in hepatocellular carcinoma.

  5. High-resolution structural data for GART (transformylase domain; purN) reveal new binding mode for lipophilic diastereoisomer inhibitors of GART, folate analogs with anti-leukemic activity.

  6. Using the SNaPshot assay, evidence presented for allelic nondisjunction at rs363506 in the GRIK1 (zeige GRIK1 Proteine) gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India.

  7. GART has an approximate seesaw geometry where terminal enzyme units display high mobility owing to flexible linker segments.

  8. The pH-dependent activity in human GART is due to its inability to bind the substrate, beta-glycinamide ribonucleotide, at low pH on the basis of structural studies at high and low pH.

  9. Substrate/cosubstrate flexibility and cosubstrate preactivation are critical for the catalytic mechanism of human GART

  10. The Expression of baseline GARTF tended to be higher in responders but this association was not significant.

Cow (Bovine) Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase (GART) Interaktionspartner

  1. Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes.

Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase (GART) Protein Überblick

Protein Überblick

The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit GART

  • phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (GART)
  • phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (gart)
  • phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (LOC100217856)
  • phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (LOC100222702)
  • GART-B (LOC427977)
  • phosphoribosylglycinamide formyltransferase (Gart)
  • AIRS Protein
  • Gaps Protein
  • GARS Protein
  • gart Protein
  • GARTF Protein
  • PAIS Protein
  • PGFT Protein
  • PRGS Protein

Bezeichner auf Proteinebene für GART

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase , phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase, isoform 1 , trifunctional purine biosynthetic protein adenosine-3-like , trifunctional purine biosynthetic protein adenosine-3 , glycinamide ribonucleotide synthetase , phosphoribosylglycinamide synthetase , aminoimidazole ribonucleotide synthetase

GENE ID SPEZIES
458518 Pan troglodytes
473968 Pan troglodytes
487740 Canis lupus familiaris
496927 Xenopus (Silurana) tropicalis
704926 Macaca mulatta
100101294 Xenopus laevis
100137547 Papio anubis
100217856 Taeniopygia guttata
100222702 Taeniopygia guttata
100328811 Oryctolagus cuniculus
100412337 Callithrix jacchus
100479165 Ailuropoda melanoleuca
100585363 Nomascus leucogenys
427977 Gallus gallus
14450 Mus musculus
288259 Rattus norvegicus
2618 Homo sapiens
281183 Bos taurus
395315 Gallus gallus
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