Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) ELISA Kits

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Zusätzlich bieten wir Ihnen Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Antikörper (32) und Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus FARS2 FARS2 69955 Q99M01
Anti-Human FARS2 FARS2 10667 O95363
Anti-Ratte FARS2 FARS2 306879 Q6AYQ3
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Weitere ELISA Kits für Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Interaktionspartner

Human Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) Interaktionspartner

  1. Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2 have been described.

  2. A newly identified missense mutation in FARS2 causes autosomal-recessive spastic paraplegia.

  3. this study expands the phenotypic spectrum of FARS2 related disease and emphasizes intragenic deletion in the list of causative mutations.

  4. the three FARS2 mutations directly impair aminoacylation function and stability of mtPheRS, leading to a decrease in overall tRNA charging capacity.

  5. Two phenylalanyl-tRNA synthetase variants Ser57Cys and Asp280Ser both display wild-type aminoacylation activity and stability with respect to their free energies of unfolding, but are less stable at low hydrogen-ion concentration (pH).

  6. Formation of the PheRS (zeige FARSA ELISA Kits)-tRNAPhe complex in human mitochondria must be accompanied by considerable rearrangement of the anticodon binding domain upon tRNA binding.

  7. Mitochondrial and cytoplasmic phenylalanyl-tRNA synthetases (HsmtPheRS and HsctPheRS, respectively) catalyze direct attachment of m-Tyr (zeige TYR ELISA Kits) to tRNA(Phe).

Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) Antigen-Profil

Beschreibung des Gens

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.

Genbezeichner und Symbole assoziert mit FARS2

  • phenylalanine-tRNA synthetase 2 (mitochondrial) (Fars2) Antikörper
  • phenylalanyl-tRNA synthetase 2, mitochondrial (FARS2) Antikörper
  • phenylalanyl-tRNA synthetase 2, mitochondrial (Fars2) Antikörper
  • 2810431B21Rik Antikörper
  • 6720478K01Rik Antikörper
  • COXPD14 Antikörper
  • dJ520B18.2 Antikörper
  • FARS1 Antikörper
  • HSPC320 Antikörper
  • PheRS Antikörper

Bezeichner auf Proteinebene für FARS2

pheRS , phenylalanine--tRNA ligase, mitochondrial , phenylalanine-tRNA synthetase 1 (mitochondrial) , phenylalanyl-tRNA synthetase, mitochondrial , dJ236A3.1 (phenylalanine-tRNA synthetase) , dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase)) , phenylalanine tRNA ligase 2, mitochondrial , phenylalanine translase , phenylalanine-tRNA synthetase 2 (mitochondrial)

GENE ID SPEZIES
69955 Mus musculus
10667 Homo sapiens
488204 Canis lupus familiaris
505390 Bos taurus
306879 Rattus norvegicus
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