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The product of PEX3 is involved in peroxisome biosynthesis and integrity. Zusätzlich bieten wir Ihnen PEX3 Antikörper (23) und viele weitere Produktgruppen zu diesem Protein an.
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that newly synthesized UBXD8 (zeige FAF2 Proteine) is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 (zeige PEX19 Proteine) and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis
This insertion of PEX3 into the ER is physiologically relevant.
PEX16 (zeige PEX16 Proteine) mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and PMP34 (zeige SLC25A17 Proteine), via the endoplasmic reticulum
Thus within the cell, PEX3 is stabilized by PEX19 (zeige PEX19 Proteine) preventing PEX3 aggregation.
Mutations in the PEX19 (zeige PEX19 Proteine)-binding domain of PEX3 reduce the affinity for PEX19 (zeige PEX19 Proteine) and destabilize PEX3.
The crystal structure of the cytosolic domain of PEX3 in complex with a PEX19 (zeige PEX19 Proteine)-derived peptide. PEX3 adopts a novel fold that is best described as a large helical bundle.
Interaction of PEX3 and PEX19 (zeige PEX19 Proteine) visualized by fluorescence resonance energy transfer (FRET).
Results suggest that PEX3 plays a selective, essential, and direct role in class I peroxisomal membrane protein import as a docking factor for PEX19 (zeige PEX19 Proteine).
either one or two tryptophan residues of Pex3p (Trp (zeige TBPL1 Proteine)-104 and Trp (zeige TBPL1 Proteine)-224) are directly involved in binding to Pex19p.
The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids.
The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS).
peroxisomal biogenesis factor 3
, transmembrane protein
, peroxisomal assembly protein PEX3
, transformation-related protein 18
, Peroxisomal assembly protein PEX3
, peroxisomal assembly protein 3
, Peroxisomal biogenesis factor 3