Peroxisomal Biogenesis Factor 3 (PEX3) ELISA Kits

The product of PEX3 is involved in peroxisome biosynthesis and integrity. Zusätzlich bieten wir Ihnen PEX3 Antikörper (22) und PEX3 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human PEX3 PEX3 8504 P56589
Anti-Maus PEX3 PEX3 56535 Q9QXY9
Anti-Ratte PEX3 PEX3 83519 Q9JJK4
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Weitere ELISA Kits für PEX3 Interaktionspartner

Human Peroxisomal Biogenesis Factor 3 (PEX3) Interaktionspartner

  1. that newly synthesized UBXD8 (zeige FAF2 ELISA Kits) is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 (zeige PEX19 ELISA Kits) and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis

  2. This insertion of PEX3 into the ER is physiologically relevant.

  3. PEX16 (zeige PEX16 ELISA Kits) mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and PMP34 (zeige SLC25A17 ELISA Kits), via the endoplasmic reticulum

  4. Thus within the cell, PEX3 is stabilized by PEX19 (zeige PEX19 ELISA Kits) preventing PEX3 aggregation.

  5. Mutations in the PEX19 (zeige PEX19 ELISA Kits)-binding domain of PEX3 reduce the affinity for PEX19 (zeige PEX19 ELISA Kits) and destabilize PEX3.

  6. The crystal structure of the cytosolic domain of PEX3 in complex with a PEX19 (zeige PEX19 ELISA Kits)-derived peptide. PEX3 adopts a novel fold that is best described as a large helical bundle.

  7. Interaction of PEX3 and PEX19 (zeige PEX19 ELISA Kits) visualized by fluorescence resonance energy transfer (FRET).

  8. Results suggest that PEX3 plays a selective, essential, and direct role in class I peroxisomal membrane protein (zeige PXMP2 ELISA Kits) import as a docking factor for PEX19 (zeige PEX19 ELISA Kits).

  9. either one or two tryptophan residues of Pex3p (Trp (zeige TBPL1 ELISA Kits)-104 and Trp (zeige TBPL1 ELISA Kits)-224) are directly involved in binding to Pex19p.

  10. The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids.

PEX3 Antigen-Profil

Beschreibung des Gens

The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS).

Genbezeichner und Symbole assoziert mit PEX3

  • peroxisomal biogenesis factor 3 (LOC692959) Antikörper
  • peroxisomal biogenesis factor 3 (CpipJ_CPIJ013204) Antikörper
  • peroxin 3 (pex3) Antikörper
  • peroxisomal biogenesis factor 3 (LOC100230879) Antikörper
  • peroxisomal biogenesis factor 3 (PEX3) Antikörper
  • peroxisomal biogenesis factor 3 (pex3) Antikörper
  • peroxisomal biogenesis factor 3 (Pex3) Antikörper
  • peroxisomal biogenesis factor 3-like (LOC100760471) Antikörper
  • 1700014F15Rik Antikörper
  • 2810027F19Rik Antikörper
  • 2900010N04Rik Antikörper
  • DDBDRAFT_0204086 Antikörper
  • DDBDRAFT_0238047 Antikörper
  • DDB_0204086 Antikörper
  • DDB_0238047 Antikörper
  • PBD10A Antikörper
  • Peroxin-3 Antikörper
  • TRG18 Antikörper
  • zgc:56313 Antikörper

Bezeichner auf Proteinebene für PEX3

peroxisomal biogenesis factor 3 , transmembrane protein , peroxin-3 , peroxisomal assembly protein PEX3 , transformation-related protein 18 , Peroxisomal assembly protein PEX3 , peroxisomal assembly protein 3 , Peroxisomal biogenesis factor 3

GENE ID SPEZIES
692959 Bombyx mori
6046074 Culex quinquefasciatus
8622947 Dictyostelium discoideum AX4
100230879 Taeniopygia guttata
100582200 Nomascus leucogenys
393197 Danio rerio
444067 Xenopus laevis
421669 Gallus gallus
8504 Homo sapiens
484015 Canis lupus familiaris
515730 Bos taurus
56535 Mus musculus
83519 Rattus norvegicus
100760471 Cricetulus griseus
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